The ratio of HDL-C to apoA-I interact with free triiodothyronine to modulate coronary artery disease risk

Abstract Objective: The present research was carried out to explore the correlation between high-density lipoprotein cholesterol (HDL-C)/ apolipoprotein A-I (apoA-I) ratio and serum free triiodothyronine (FT3) and their interaction on the risk of coronary artery disease (CAD). Methods: A total of 1,686 patients underwent selective coronary angiography, including 1,279 CAD patients and 407 controls were enrolled in the present study. The subjects were divided into three groups according to tertiles of HDL-C/apoA-I. Binary logistic regression analysis was used to evaluate the interaction of HDL-C/apoA-I and FT3 on the risk of CAD.Results: The group with highest HDL-C/apoA-I had the lowest FT3 levels. Multiple linear regression analysis showed that HDL-C/apoA-I were negatively associated with FT3 after adjusting age, sex, body mass index (BMI), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoproteinB (ApoB). Logistic regression model showed that high HDL-C/apoA-I (>0.89mmol/g) and high FT3 level (>4.5pmol/l) were protective factor for CAD. Patients with the lower HDL-C/ apoA-I (≤0.89mmol/g) and FT3 level (≤4.5pmol/l) have an increased risk of CAD (OR =2.441, P=0.000, S =1.13, AP=0.068, AP* = 0.116, RERI=0.168).Conclusions: Lower HDL-C/ apoA-I was risk factor for CAD and there was a positive interaction between HDL-C/ apoA-I and FT3 on the risk of CAD.