Effect of exercise and Yoga program on renin-angiotensin mechanism in cardiac autonomic neuropathy in Diabetes mellitus patients.

Effect of exercise and Yoga program on renin-angiotensin mechanism in cardiac autonomic neuropathy in Diabetes mellitus patients. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Effect of exercise and Yoga program on renin-angiotensin mechanism in cardiac autonomic neuropathy in Diabetes mellitus patients. Sandip Meghnad Hulke, Sagar Khadanga, Ashwin Laxmikant Kotnis, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3865680/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Cardiac autonomic neuropathy (CAN) is one of the frequent complications of diabetes mellitus. Renin-angiotensin mechanism play role in the development of CAN which may be affected by exercise as well as yoga. Aim of the study was to study the effect of a 6-month supervised exercise program/ Yoga program on cardiac autonomic neuropathy (CAN) status and renin angiotensin (RAAS) parameters in a diagnosed case of CAN in Diabetes mellitus patients. Method: Diagnosed patients with CAN in diabetes mellitus would be randomly divided into two groups. One group will undergo a supervised exercise program and the other would follow a supervised YOGA program. CAN parameters and RAS mechanism parameters would be assessed before and after the start of the exercise/Yoga program. CAN parameters and RAAS parameters would be assessed using a cardiac autonomic function test battery and measurement of Plasma renin, Serum aldosterone, Angiotensin II, ACE, and Angiotensin (1-7) respectively. Discussion: The effect of exercise on cardiac autonomic function has been assessed, however, these studies are limited, the strength of evidence is low, and the need for RCT was stressed. How does exercise affect the RAS mechanism? There are limited studies in this area. Further various research has been recommended to study various components of the RAS mechanism. In India, work has been done mainly to assess the effect of the YOGA program on cardiac autonomic function in diabetes mellitus. There are no uniform findings. Further, literature regarding its effect on the RAS mechanism is limited. Internationally, work is focused on various exercise programs, while the focus was on the yoga program in India. There is a need to assess the effect of such a supervised program on the Indian population. Trial registration: Registered with clinical trial registry of India and registration number is CTRI/2023/05/052268, registered retrospectively Keywords: Diabetes mellitus, cardiac autonomic neuropathy, angiotensin, rennin Diabetes mellitus cardiac autonomic neuropathy angiotensin rennin Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3865680","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":305195082,"identity":"89c45da2-4083-471a-a761-38785a2b2704","order_by":0,"name":"Sandip Meghnad Hulke","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4ElEQVRIiWNgGAWjYFACHvbPP//YABmJDR8qgFw+IrSwMTM2pIG0NM44A+ISqeUwkJHACNLCQFCL/LSzxx4X7jifz8+e3NhwMMdOho2B+eGjG3i0GNzOSzeeeea25cyeh0At25KBDmMzNs7Bp0U6x0CCh+22gcGNxPbHH7cxA7XwsEnj0yI/G6zlnIH9jUSQLfWEtTDczjGT5m07YGAgAdZymLAWg9s5xoYzziQbSJwB++U4MAAJ+AXoMMMHHyrsDPjb0x8CtVTb87M3P3yM12GYgJk05aNgFIyCUTAKsAAAZhZNUpfwnzYAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-1351-9958","institution":"AIIMS BHOPAL","correspondingAuthor":true,"prefix":"","firstName":"Sandip","middleName":"Meghnad","lastName":"Hulke","suffix":""},{"id":305195083,"identity":"d801c8f9-8532-4128-8d84-8d2eac8d1680","order_by":1,"name":"Sagar Khadanga","email":"","orcid":"","institution":"All India Institute of Medical Science - 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Renin-angiotensin mechanism play role in the development of CAN which may be affected by exercise as well as yoga. Aim of the study was to study the effect of a 6-month supervised exercise program/ Yoga program on cardiac autonomic neuropathy (CAN) status and renin angiotensin (RAAS) parameters in a diagnosed case of CAN in Diabetes mellitus patients.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod:\u003c/strong\u003e Diagnosed patients with CAN in diabetes mellitus would be randomly divided into two groups. One group will undergo a supervised exercise program and the other would follow a supervised YOGA program. CAN parameters and RAS mechanism parameters would be assessed before and after the start of the exercise/Yoga program. CAN parameters and RAAS parameters would be assessed using a cardiac autonomic function test battery and measurement of Plasma renin, Serum aldosterone, Angiotensin II, ACE, and Angiotensin (1-7) respectively.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDiscussion:\u003c/strong\u003e The effect of exercise on cardiac autonomic function has been assessed, however, these studies are limited, the strength of evidence is low, and the need for RCT was stressed. How does exercise affect the RAS mechanism? There are limited studies in this area. Further various research has been recommended to study various components of the RAS mechanism. In India, work has been done mainly to assess the effect of the YOGA program on cardiac autonomic function in diabetes mellitus. There are no uniform findings. Further, literature regarding its effect on the RAS mechanism is limited. Internationally, work is focused on various exercise programs, while the focus was on the yoga program in India. There is a need to assess the effect of such a supervised program on the Indian population.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTrial registration:\u003c/strong\u003e Registered with clinical trial registry of India and registration number is CTRI/2023/05/052268, registered retrospectively Keywords: Diabetes mellitus, cardiac autonomic neuropathy, angiotensin, rennin\u003c/p\u003e","manuscriptTitle":"Effect of exercise and Yoga program on renin-angiotensin mechanism in cardiac autonomic neuropathy in Diabetes mellitus patients.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-03 02:40:39","doi":"10.21203/rs.3.rs-3865680/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0631033c-646b-4cda-81b8-03a3e0159959","owner":[],"postedDate":"June 3rd, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-07-23T04:45:11+00:00","versionOfRecord":[],"versionCreatedAt":"2024-06-03 02:40:39","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3865680","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3865680","identity":"rs-3865680","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}