Outcome measures in therapeutic studies of urinary tract infection in pregnancy: a systematic review

Outcome measures in therapeutic studies of urinary tract infection in pregnancy: a systematic review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 9 September 2025 V1 Latest version Share on Outcome measures in therapeutic studies of urinary tract infection in pregnancy: a systematic review Authors : Natasha Noordin , Natasha Liou S 0000-0002-5644-2604 , Anna David 0000-0002-0199-6140 , and Jane Currie LD [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175742004.41989130/v1 196 views 129 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background Urinary tract infection (UTI) in pregnancy, including asymptomatic bacteriuria, has been associated with adverse outcomes including preterm birth and pyelonephritis. Treatment with antibiotics has been recommended. However, evidence for treating asymptomatic UTI in pregnancy has recently been challenged. It is important to evaluate the outcomes that have been already studied to better understand the evidence for interventions in UTI in pregnancy. Objectives Systematic review of outcome measures reported in studies of interventions for UTI in pregnancy. Search strategy Search strategy followed PRISMA guidelines and registered prospectively with Prospero database (CRD42021235185). Selection criteria All studies of intervention for UTI in pregnancy, published between 2011-2020 in English, involving randomised trials, systematic reviews, cohort and case-control studies and clinical trial protocols. Databases searched: Cochrane Database of Systematic Reviews, MEDLINE, and EMBASE (February 2021). Data collection and analysis Screening using Covidence software; data collection by template using Excel; thematic analysis. All steps performed by two independent reviewers with a third for disagreements. Main results In 41 included studies, just over half stated the definition of UTI or described the diagnostic test used. There was significant heterogeneity: of 297 outcomes, only 27.3% were clearly defined and only two thirds prioritised outcomes as primary or secondary. There was a paucity of long-term outcomes or patient-satisfaction outcomes. Conclusions The heterogeneity in outcomes studied makes comparison difficult, impairing meta-analysis. Studies focussed on immediate or easy-to-measure outcomes without considering long-term or patient-derived outcomes. There is a need for a core outcome set for UTI in pregnancy studies. Supplementary Material File (appendix s1 search strategy.docx) Download 118.26 KB File (figures for systematic review of uti outcomes paper 080925.docx) Download 379.10 KB File (prisma_2020_abstract_checklist sr uti outcomes 060925.docx) Download 357.68 KB File (prisma_2020_checklist sr uti outcomes 050925.docx) Download 362.06 KB File (supplementary tables uti outcomes sr 060925.docx) Download 214.26 KB File (systematic review of outcomes uti in pregnancy 080925 corrected.docx) Download 161.84 KB File (tables for systematic review of outcomes paper 080925.docx) Download 67.90 KB Information & Authors Information Version history V1 Version 1 09 September 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords general obstetrics infectious disease: microbiology systematic reviews Authors Affiliations Natasha Noordin University College London School of Life and Medical Sciences View all articles by this author Natasha Liou S 0000-0002-5644-2604 University College London Elizabeth Garrett Anderson Institute for Women's Health View all articles by this author Anna David 0000-0002-0199-6140 University College London Elizabeth Garrett Anderson Institute for Women's Health View all articles by this author Jane Currie LD [email protected] University College London Elizabeth Garrett Anderson Institute for Women's Health View all articles by this author Metrics & Citations Metrics Article Usage 196 views 129 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Natasha Noordin, Natasha Liou S, Anna David, et al. Outcome measures in therapeutic studies of urinary tract infection in pregnancy: a systematic review. Authorea . 09 September 2025. DOI: https://doi.org/10.22541/au.175742004.41989130/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.175742004.41989130/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a003f43c4e0f1b23',t:'MTc3OTUzODE5MA=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();