Effects of Risperidone on Serum Testosterone and Metabolic Parameters Among Schizophrenic Patients in Khartoum State, Sudan.

Abstract Background: Antipsychotics (AP) are commonly and increasingly prescribed to children and adolescents effectively for the treatment of schizophrenia symptoms, but they are often associated with different side effects, many studies report a decrease in testosterone and gonadotropins due to an AP-induced hyperprolactinemic effect in men, it has been found that lower levels of testosterone is correlated with negative symptoms in patients with schizophrenia.Aim: Study was aimed to determine the effect of Risperdone on testosterone level in patients with Schizophrenia in Khartoum State.Materials and Methods: A cross sectional hospital based study recruited 100 patients diagnosed with Schizophrenia, attended at Military Hospital, Khartoum state, during January to March 2021. The plasma testosterone was estimated using ichromaTM semi automated analyzer, the collected data were analyzed using SPSS version (25).Results: A cross sectional study recruited 100 patients, diagnosed with Schizophrenia, attended Military Hospital during January 2021, their age range from 25 to 52 years old (mean±SD = 38.1±6.42), to estimate testosterone levels in their plasma beside determine BMI and signs and symptoms related to Schizophrenia. The study found that mean of testosterone level was 3.44±2.11, mean of glucose level was 146.4±22.57 SD while mean of uric acid was 6.51±0.85 with strong significant statistical differences P. value = 0.001, 0.001 and 0.002 respectively, reverse correlation was observed between testosterone and body mass index, age, duration of the disease, glucose and uric acid levels (R= -0.33, -0.32, -0.37, -0.22 and -0.20 respectively).Conclusion: Risperidone drug used in treatment patients with Schizophrenia was lowering the level of testosterone hormone. And also there was association between testosterone with blood glucose, uric acid, age and duration of disease.