Анализ программ ЭКО у женщин с различным уровнем прогестерона в день введения триггера овуляции

Objective – to study the efficacy of IVF in women with different levels of serum progesterone on the trigger day. Material and methods . A retrospective study of the effectiveness of IVF programs in 313 patients: group I – with a progesterone level of less than 0,6 ng/ml (n=75 (24%), age 33,2±2,1), group II – progesterone 0,6–1,5 ng/ml (n=189 (60,4%), age 32,5±3,1), group III – progesterone more than 1,5 ng/ml (n=49 (15,6%), age 32,9±2,9). Results . Groups with different levels of progesterone on the trigger day did not differ in such parameters as the woman’s age, the cause and duration of infertility, the number of previous IVF programs, the history of surgical interventions, the endometrial thickness and the day of the cycle at the embryo transfer. With low progesterone, a decrease in AMG was found in 22,7%, absence of oocytes during stimulation – in 14,7%, less than 5 mature oocytes – in 86,7%, pregnancy rate for embryo transfer (PR) was 13,2%. Low (less than 0,6 ng/ml) progesterone is characterized by the high frequency of canceling of embryo transfer due to embryo loss (25,3%). High (more than 1,5 ng/ml) progesterone is characterized by the high frequency of canceling of embryotransfer due to risk of severe Ovarian Hyper Stimulation Syndrome (22,5%). In the group with high progesterone PR was 22,6%. At a progesterone level of 0,6–1,5 ng/ ml is the best outcomes in terms of pregnancy (PR was 30,4%). Conclusions . Hormonal monitoring in ART programs allows individualizing the stimulation protocols and adapting  them to the patient’s characteristics.