Histological Differentiation Grade and Surgery Affects Short-Term Mortality in Esophageal Squamous Cell Carcinoma Patients

Abstract Background: This study aimed to examine the relationship between the clinicopathological features, nutritional and inflammatory status, type of treatment, and short-term mortality in esophageal squamous cell carcinoma (ESCC) patients. Methods: 205 patients with ESCC were included. The following malnutrition and inflammation criteria at the time of diagnosis were applied: body mass index < 18.5 kg/m2, serum albumin level 3.5, platelet-to-lymphocyte ratio (PLR) > 17 and C-reactive protein. Clinicopathological features, Malnutrition status, inflammatory condition and the type of treatment were analyzed for 3-month and 6-month mortality rates by univariate and multivariate analysis. Results: The 3-month and 6-month mortality rates were 13.2% and 27.3%, respectively. The multivariate logistic regression model after adjustment for clinicopathological variables and comorbid status found that surgery and histological differentiation grade were prognostic factors for short-term mortality. Conclusions: In addition to surgery, histological differentiation grade independently contributes to high short-term mortality of ESCC patients.