LDL-C/HDL-C ratio:a strong metabolic risk factor of invasive breast cancer

Objective: Our study aims to evaluate whether low density lipoprotein cholesterol/high density lipoprotein cholesterol (LDL-C/HDL-C) can act as a metabolic risk factor of invasive breast cancer (BC) in females. Methods: : From January,2022 to December, 2022,505 females invasive BC and 505 age-matched controls were prospectively enrolled in our study. Data were obtained via medical records and questionnaires.We used Student’s t -test and Pearson’s χ2 test to assess the baseline characterisitcs, and binary logistic regression was utilized to clarify the metabolic risk factors of invasive BC. Finally, stratified analyses were performed according to estrogen receptor(ER) status. Results: : LDL-C/HDL-C,waist circumference (WC),coronary heart disease and family history of cancer were independent risk factors of invasive BC. Among the metabolic factors,higher LDL-C/HDL-C ratio(OR,25.19,95%CI,13.15-48.25) and WC(OR,1.20,95%CI,1.15-1.24) were associa- -ted with higher BC risk( P <0.05) after adjustment for the potential confounders. Stratified analyses according to ER state also demonstrated that LDL-C/HDL-C and WC were still independent risk factors regardless of whether ER status was positive or negative( P ＜0.05). Conclusions: : We find that LDL-C/HDL-C ratio is a strong metabolic risk factor of invasive BC regardless of whether ER status was positive or negative.