Gold nanoparticles’ concentration dependent reactivity to alendronate, memantine, andtobramycin

Turkevich gold nanoparticles are the original nanoparticles that have been modified over time. Its combination with targeting medications such as alendronate, memantine, and tobramycin will provide additional benefits intargeting specific areas in the bone, brain, and microorganisms, respectively.Hence, The reactivity and stability of nanoparticles with various drugconcentrations (milli-,micro-, and nano-levels) have been studied. Withalendronate, the absorbance spectra of nanoparticles at λmax 520 nm werealways stable and no redshifts occurred. In contrast, the spectra with memantineand tobramycin were stable at the nano-level and redshifts occurred at the milli-& micro- levels. HRTEM and DLS revealed that the core diameter was relativelystable in all cases, whereas the hydrodynamic diameter & zeta potential variedwith varying drug concentrations. Increasing concentration increasedhydrodynamic diameter slightly with memantine (from 64.99 to 98.41 nm),dramatically with tobramycin (from 135.3 to 332.16 nm), and almost negligiblywith alendronate (from 52.08 to 58.94 nm ). Zeta Potential, conversely, isreduced as concentration increases. Memantine had the greatest reduction innegativity, followed by tobramycin, but alendronate had a slight increase innegativity. Benefits from this research would be in targeted drug delivery, wherestability and reactivity of gold nanoparticles are critical.