Subclinical/Overt hypothyroidism and its association with the anti-thyroid antibodies at 6 weeks postpartum in the women diagnosed with subclinical hypothyroidism during pregnancy: A prospective cohort study.

Subclinical/Overt hypothyroidism and its association with the anti-thyroid antibodies at 6 weeks postpartum in the women diagnosed with subclinical hypothyroidism during pregnancy: A prospective cohort study. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Chitra Authors Info & Affiliations https://doi.org/10.22541/au.174952451.15137934/v1 191 views 94 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective : Estimate the proportion of subclinical/Overt hypothyroidism at 6 weeks post-partum in women diagnosed with subclinical hypothyroidism during current pregnancy and its association with anti-thyroid antibodies. Secondary objective is to estimate the proportion of congenital hypothyroidism in these babies. Design : Prospective Cohort study Setting : Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Tertiary care hospital, Puducherry, India. Population : Pregnant women >18years, diagnosed with subclinical hypothyroidism (SCH)during current pregnancy at 14-28 weeks of gestation. Methods : TSH, FT3, FT4, Anti-Thyroid peroxidase antibody & Anti-thyroglobulin antibodies were assessed antenatally and postnatally at six weeks. Neonatal TSH on day-3 were done. Main outcome measures : Proportion of persisting Subclinical hypothyroidism and congenital hypothyroidism. Association of antithyroid antibodies with postnatal subclinical hypothyroidism. Results: 156 participants were included, 15.3% had persisting SCH at six weeks postpartum. There was no significant association between Anti Thyroid antibodies with the persistence of SCH in the postnatal period. However, the percentage of subjects with anti-thyroid antibody positivity in the antenatal period was 23.7 %; it increased by 7.1 % in the postnatal follow-up (p=0.001). Congenital hypothyroidism was detected in 2% of cases. Conclusions : At six weeks postpartum, 15.3% of women had persisting SCH, emphasizing the need for routine postnatal screening. Long-time follow up studies are required for establishing its association with Anti-thyroid antibodies. The higher incidence of congenital hypothyroidism (2%) highlights the need for neonatal thyroid screening. Funding : Nil Keywords: Subclinical hypothyroidism, postpartum thyroid function, anti-thyroid antibodies, gestational hypothyroidism. Supplementary Material File (sch -tables.docx) Download 18.56 KB File (sch-main doc.docx) Download 44.33 KB Information & Authors Information Version history V1 Version 1 10 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords endocrinology maternal medicine medical disorders in pregnancy puerperium Authors Affiliations Hastha Aithal R Jawaharlal Institute of Postgraduate Medical Education and Research View all articles by this author Sujithra Devi R 0000-0003-1076-5325 [email protected] Jawaharlal Institute of Postgraduate Medical Education and Research View all articles by this author Jaya Prakash Sahoo Jawaharlal Institute of Postgraduate Medical Education and Research View all articles by this author T. Chitra Jawaharlal Institute of Postgraduate Medical Education and Research View all articles by this author Metrics & Citations Metrics Article Usage 191 views 94 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Hastha Aithal R, Sujithra Devi R, Jaya Prakash Sahoo, et al. Subclinical/Overt hypothyroidism and its association with the anti-thyroid antibodies at 6 weeks postpartum in the women diagnosed with subclinical hypothyroidism during pregnancy: A prospective cohort study.. Authorea . 10 June 2025. DOI: https://doi.org/10.22541/au.174952451.15137934/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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