Identifying Anti-CRISPR Small Molecules via High-throughput Assay
preprint
OA: closed
CC-BY-4.0
Abstract
Abstract There is a high demand for anti-CRISPR molecules to precisely control CRISPR-associated nucleases. Small molecule anti-CRISPRs can be easily delivered to cells and improve CRISPR editing outcomes by their fast action and temporal control of nuclease activity, though no assays currently exist for the high-throughput identification of these compounds. Here we report a high-throughput assay platform to rapidly identify multiple small-molecule inhibitors of SpCas9.
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Source provenance
- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-05-29T02:00:03.542394+00:00
License: CC-BY-4.0