The effect of coronary artery disease on the prognosis of hypertrophic cardiomyopathy: a multi-center cohort study

Background: There is a paucity of patients with hypertrophic cardiomyopathy (HCM) developed coronary artery disease (CAD), and the impact of CAD on the prognosis of HCM patients is unknown. Therefore, our real-world cohort study aimed to investigate prognosis of CAD in patients with HCM. Methods: : A cohort study was undertaken in HCM patients from May 2003 to September 2021. A total of 2268 patients were enrolled, with a mean follow-up of 5.6 years (interquartile range 2.4-8.4 years). Outcome assessment was based on the all-cause mortality, cardiovascular mortality/cardiac transplantation and SCD. Results: : Among the 2268 patients studied, 353(15.6%) died during a mean follow-up of 5.6 years. The patients were divided into CAD (n=504) and non-CAD (n=1764) groups. No difference in the all-cause mortality, cardiovascular mortality/cardiac transplantation or SCD between patients with CAD and no CAD (log-rank c 2 =0.201, P=0.654; log-rank c 2 =0.233, P=0.629; log-rank c 2 =1.523, P=0.217). In the Cox analysis, CAD was not a significant independent predictor of all-cause mortality, cardiovascular mortality/cardiac transplantation or SCD in patients with HCM. Conclusion: In conclusion, there was no significant differences in mortality between the HCM patients with and without CAD, indicating no effect of CAD on all-cause mortality, cardiovascular mortality/cardiac transplantation, and SCD in the present large-scale study.