Awareness and Implementation of Comprehensive Genomic Profiling and Adolescent and Young Adult Cancer Support among Healthcare Professionals in Osaka, Japan

Abstract Background Comprehensive genomic profiling (CGP) and specialized support for adolescent and young adult (AYA) cancer patients are crucial yet underexplored areas of healthcare in Japan. This study investigated awareness of CGP testing and support for AYA cancer patients among healthcare professionals in Osaka. Methods An anonymous online survey was conducted from January 31 to March 31, 2024. The survey targeted all staff, including doctors, nurses, technicians, pharmacists, and others, from eight hospitals in the Toyono Medical Area Cancer Medical Network Council. The survey included questions on basic demographics, awareness of CGP testing, and support provided to patients with AYA cancer. Results Among the 720 respondents, 41.9% were aware of CGP testing, while 20.3% were unaware. Regarding AYA cancer, 60.7% were aware, and 14.3% were unaware. Only 7.5% had frequent contact with AYA patients, and 96.8% recognized the need for more training. Awareness of CGP was greater among doctors (72.5%) than among other professionals (34.4%); similarly, AYA cancer awareness was greater among doctors (73.9%) than among other professionals (57.7%). CGP awareness among doctors varied by experience year and institutional type, being highest in core and cooperative hospitals (80% and 78.6%, respectively) and among doctors with more than 21 years of experience (90%). Conclusions This study reveals significant gaps in CGP and AYA cancer awareness among healthcare professionals in Osaka, Japan, with doctors exhibiting higher awareness levels than other professionals. There is a pressing need for targeted educational programs to enhance the understanding and implementation of CGP and support AYA cancer patients. Mini-Abstract Significant gaps in genomic profiling and AYA cancer awareness exist among Osaka healthcare professionals, with doctors showing higher awareness. Targeted education is needed to improve understanding and support.