Comparison of Endometriosis Characteristics in Adolescents and Women of Advanced Reproductive Age

Objective: To compare clinical and pathological characteristics of endometriosis between adolescents (10–19 years) and women of advanced reproductive age (35–45 years) to guide early diagnosis and tailored management.

A retrospective, cross-sectional study of 68 patients (31 adolescents; 37 advanced-age women) with laparoscopically and histopathologically confirmed endometriosis at Dr. Margono Soekarjo Regional General Hospital between January 2022 and December 2024. Statistical analyses included independent t-tests, chi-square tests, and multivariate logistic regression.

Adolescents exhibited higher dysmenorrhea prevalence (80.6% vs. 43.2%; p=0.003), more early-stage disease (Stage I–II: 71% vs. 22%; p<0.001), and increased peritoneal lesions (29% vs. 8%; p=0.030). They also had lower BMI (21.4 vs. 24.3 kg/m²; p=0.007) and earlier menarche (12.9 vs. 13.8 years; p=0.016). Advanced-age women predominantly presented with late-stage disease (Stage III–IV: 78%) and showed significant associations with age (OR 1.15; 95% CI 1.02–1.30), primiparity (OR 5.67; 95% CI 1.23–26.12), multiparity (OR 6.23; 95% CI 1.34–28.98), and Stage III–IV disease (OR 4.89; 95% CI 1.25–19.16).

Endometriosis in adolescents manifests as severe dysmenorrhea, milder stages, and peritoneal involvement, whereas older women present with advanced disease linked to age and parity. Age-specific diagnostic vigilance and management are essential

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