Evaluation of cellular and molecular and anti-apoptotic effects of lipid nanoparticle-containing Artemisia extract in ovarian cancer cells

Abstract Ovarian cancer is the fifth reason for the woman's death. When cells get malignant changes in one or both ovaries, ovarian cancer gets formed. This kind of cancer when it is under control, it influenced the fertility of the patient. Artemisia Aucheri Boiss is used for most of the diseases to be healed. Due to the importance of ovarian cancer and the potential of anti-Apoptotic of Artemisia Aucheri Boiss, in this research the extraction of this plant in lipid nanoparticles with the target of cellular and molecular effects and anti Apoptotic loaded on the ovarian cancer cells. In this examination, first nanoparticles containing Artemisia extraction were synthesized by homogenizer plus sonication and subsequently their physical and chemical properties were determined like (size and shape of particles, description of particles, zeta potential, rate of efficiency of essential oil. Then the anti Apoptotic effect of lipid nanoparticle-containing Artemisia extraction in ovarian cancer cells (SKOV-3 line) was determined by MTT assay and flow cytometry analysis.Results of the cellular effects of lipid nanoparticle-containing extraction of the plant on the ovarian cancer cells show that the increase of viscosity of lipid nanoparticle containing the essence of this plant led to disease in the viability of ovarian cancer cells compared to pure essence. It seem that lipid nanoparticles appear to activate the apoptotic pathway in ovarian cancer cells.