The relationship of Ki67 and VEGF in adenomyosis uterus

Objective:To investigate the expressions of Ki67 and VEGF in the pathogenesis of adenomyosis uterus.Methods:The expressions of Ki67 and VEGF in 30 cases of adenomyosis uterus were detected by immunohistochemical EnVision method.Results:The positive rates of Ki67 and VEGF in ectopic endometrium of myometrium were 53.3% and 96.7%, respectively.The expressions of Ki67 and VEGF increased significantly in ectopic endometrium were slightly than those in eutopic endometrium(P0.05).The strong positive rate in the eutopic endometrium was significantly higher than that in the stroma cells(P0.05).In adenomyosis, no significant changes of VEGF expression was found throughout the menstrual cycle(P0.05).The expression of VEGF had a positive correlation with the expression of Ki67(P0.01).Conclusion:Adenomyosis is an endometrial proliferative disease.Ki67 and VEGF all express in the ectopic and eutopic endometrium. They may be play an important roles in clinical symptoms of adenomyosis.