Decreased peripheral blood lymphocyte-monocyte ratio and platelet-monocyte ratio and the Peripheral Blood Score model predict poor survival in peripheral T-cell lymphoma patients

Decreased peripheral blood lymphocyte-monocyte ratio and platelet-monocyte ratio and the Peripheral Blood Score model predict poor survival in peripheral T-cell lymphoma patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Primary research Decreased peripheral blood lymphocyte-monocyte ratio and platelet-monocyte ratio and the Peripheral Blood Score model predict poor survival in peripheral T-cell lymphoma patients Yan Zhang, Yuanfei Shi, Huafei Shen, Lihong Shou, Qiu Fang, Xiaolong Zheng, and 10 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-130878/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Background Peripheral T-cell lymphoma(PTCL) is a group of lymphoproliferative tumors originated from post-thymic T cells or mature natural killer (NK) cells. It shows highly aggressive clinical behaviour, resistance to conventional chemotherapy, and a poor prognosis. Its incidence rate in China is 1 to 2 times higher than in western countries. Therefore, optimal strategies for identifying high-risk patients are urgently needed. Materials and Methods We retrospectively studied 347 newly diagnosed PTCL patients from January 2011 to October 2019 and analyzed the relationship between peripheral blood lymphocyte-monocyte ratio (LMR) and platelet-monocyte ratio (PMR) and prognosis. The model of Peripheral Blood Score was established to screen out high-risk patients. Results The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value based on survival rate. It was found that patients with PTCL with LMR ≤ 1.68 and PMR ≤ 300 had inferior overall survival (OS) and the difference was significant in both low-risk (P<0.001) and medium high-risk (P<0.001) groups of IPI score. In multivariate analysis, LMR ≤ 1.68 (HR=1.751, 95% CI 1.158-2.647, p=0.006), PMR ≤ 300 (HR=1.762, 95% CI 1.201-2.586, p=0.002), stage III-IV (HR=3.276, 95% CI 1.512-7.099, p=0.003), Eastern Cooperative Oncology Group (ECOG) score 3-5 (HR=2.351, 95% CI 1.647-3.356, p<0.001) and extra-nodal invasion more than one site (HR=1.659, 95% CI 1.125-2.445, p=0.039) were independently associated with short survival. LMR and PMR were integrated into "Peripheral Blood Score (PBS)" model. PTCL patients were divided into three risk groups: low-risk group, medium risk group and high-risk group. The 1-year OS was 86%, 55.3% and 22.6%, and the 3-year OS was 43.4%, 20% and 13.1%, respectively. Conclusion Overall, LMR and PMR can be used as early prognostic indicators in PTCL patients. Moreover, we can easily detect the complete blood cell count (CBC), and use PBS model to preliminarily screen and stratify patients. It is simple, convenient and accurate to screen out patients with short lives, and formulate personalized treatment strategies. Cancer Biology Oncology peripheral T-cell lymphoma lymphocyte platelet monocyte prognosis tumor micro-environment immunity Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction Peripheral T-cell lymphoma(PTCL) is a group of rare hematological malignancies with heterogeneous morphological and biological characteristics. The overall manifestations are high invasiveness, short survival and poor prognosis. The total incidence rate is 0.5-2, per 100000 persons per year, and account for about 10% of all non-Hodgkin’s lymphomas (NHL) in Western countries[1]. However, the incidence of PTCL in Asia is higher, accounting for 25%-30% of NHL in China[2]. Nowadays, the internationally recommended first line therapy is still anthracycline-based chemotherapy. But the complete response (CR) rate after chemotherapy is only 40%-60% , with overall survival (OS) of 30-40% . Most patients face the problem of short-term recurrence [3]. And the recurrence or progression of the lack of effective treatment measures [4-5]. According to the WHO classification, PTCL can be further divided into many pathological subtypes. The most common subtypes include PTCL-not otherwise specified (PTCL-NOS), extra-nodal natural killer (NK)/T cell lymphoma, nasal type (ENKTL), angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ ALCL) and anaplastic lymphoma kinase negative anaplastic large cell lymphoma (ALK- ALCL) [6]. In addition, there are some rare subtypes, such as monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL), subcutaneous panniculitis like T-cell lymphoma(SPTCL), mycosisfungoides/Sezary’s syndrome(MF/SS), Hepatosplenic T-cell lymphoma (HSTCL) and so on. Due to its rarity and heterogeneity, the prognosis of PTCL are less studied. International Prognostic Index (IPI) confirmed its usefulness for PTCL including age, Eastern Cooperative Oncology Group (ECOG), Ann Arbor staging, lactic dehydrogenase (LDH) and extra-nodal invasion [3]. The Intergruppo Italiano Linfomi (now Fondazione Italiana linfomi, FIL) performed a large study in the 1990s on 385 patients diagnosed and treated. Based on this study, they identified a prognostic model, the Prognostic Index for PTCL-unspecified (PIT). The results showed that age, ECOG, LDH and bone-marrow involvement were independent predictors of OS and they confirmed that the PIT was slightly more effective than the IPI in PTCL-NOS patients[7]. But even so, these scoring systems are relatively complex and need to be evaluated from multiple aspects. Therefore, our study found that through the determination of peripheral blood lymphocyte-monocyte count ratio and platelet-monocyte count ratio could be simple and effective to screen out high-risk patients. Tumor micro-environment, host immunity and systemic inflammatory response are the key factors that determine the clinical course and prognosis of tumor patients. More and more studies found tumor-associated macrophages (TAMs) are associated with poor clinical prognosis of a variety of tumors, including colon cancer, thyroid cancer and Burkitt’s lymphoma by promoting angiogenesis, local invasion and metastasis[8-10]. Moreover, it has been confirmed that the growth and survival of malignant T cells depend on alternatively activated (M2) macrophages in micro-environment, and the growth of alternatively activated (M2) macrophages are affected by TAMs [11-12]. Yingming Zhu et al. found that serum monocytes were locally absorbed and differentiated into macrophages after tumor invasion, and reacted to a wide range of chemokines and growth or differentiation factors such as CCL-2 and CSF-1 produced by tumor and stromal cells, and further confirmed the correlation between LMR and TILs / TAMs ratio[13]. Increasing evidence indicates that platelets play several roles in the progression of malignancies and in cancer-associated thrombosis. A notable cross-communication exists between platelets and cancer cells[14]. CXCL12 promoted monocytes and M1-M2 macrophages to phagocytic apoptosis platelets, and promoted their differentiation into foam cells through CXCR4 and CXCR7. Therefore, platelet derived CXCL12 could regulate monocyte macrophage functions through the different binding of CXCR4 and CXCR7, which indicated that they played an important role in the inflammatory reaction of platelet aggregation site[15]. Our study is the first time to discuss the relationship between PMR, LMR and prognosis of PTCL. We found that the decreased of PMR and LMR were closely related to the low survival of PTCL. On this basis, we established a peripheral blood score (PBS) model to identify high-risk patients early. Materials And Methods 2.1 Patients and characteristics This is a single center retrospective study. A total of 347 patients with PTCL newly diagnosed in the First Affiliated Hospital of Zhejiang University School of Medicine from January 2011 to October 2019 were included. The final observation time was January 2020, and the median follow-up time was 18 months (rang: 0-108 months). The inclusion criteria were as follows: (1) Age ≥15 years; (2) The pathological diagnosis was consistent with PTCL; (3) Newly diagnosed and no chemotherapy before clinical data were collected; (4) Complete clinical data; (5) At least two cycles of treatment were given. Although the treatment plan were not completely unified, all the patients in our study received cyclophosphamide-doxorubicin-vincristine-prednisone (CHOP) or CHOP-like chemotherapy regimen, and all ENKTL patients were treated with chemotherapy combined with Pegaspargase. All procedures involving human participants in our study were conducted in accordance with the Helsinki declaration. We collected the medical records, physical examinations, laboratory results, pathological reports and radiological results of these patients through electronic medical records, and re analyzed the clinical data of them. All baseline data are presented in Table 1. Follow-up was performed by making phone calls. The absolute counts of lymphocytes, monocytes and platelets were obtained from a standard complete blood count (CBC) performed at diagnosis. LMR was the absolute count of lymphocyte divided by the absolute count of monocyte. PMR was the ratio of platelet absolute count to monocyte absolute count. OS was defined as the time from diagnosis to death for any reasons or last follow-up. 2.2 Cut-off value for LMR/PMR The optimal cut-off of LMR and PMR were obtained by calculating the area under the curve by receiver operating characteristic (ROC) curve analysis. 2.3 Statistical analysis Post hoc power analyses were conducted with GPOWER (Faul, Erdfelder, Lang, & Buchner, 2007) in order to estimate the probability of occurrence of effects in the sample. Through the normal distribution test, the continuous variables included in this study all conform to the normal distribution. The continuous variables such as lymphocyte count, monocyte count and platelet count were shown as median with range and were compared by Mann-Whitney U-test. Other continuous variables were grouped according to the usual clinical threshold and were presented as frequencies and percentages (n, %) in company with categorical variables. All hierarchical and categorical variables were compared by Pearson's chi-square test. Among them, histological subtypes were performed bonferroni-post-hoc-correction. Kaplan-Meier curve was used to analyze OS and log-rank test was used for comparison. Univariate and multivariate logistic regression models were used to evaluate the correlation between clinical variables and complete remission (CR). Cox proportional hazard regression model was used to analyze univariate and multivariate of OS. Statistical analysis was performed by spss23.0 software package. In all comparisons, the results were considered to be statistically significant when the p value was < 0.05, and 95% confidence interval (CI) was given. Results 3.1 Patients Characteristics According to the admission conditions, we enrolled 347 patients with newly diagnosed PTCL for analysis. The clinical characteristics and laboratory data were listed in Table 1. The four most common subtypes of PTCL-NOS, ENKTL, AITL and ALCL accounted for 32.0%, 32.5%, 20.2% and 11.8%, respectively. Other rare subtypes including MEITL, SPTCL, HSTCL and MF/SS accounted for 3.5% totally. However, the different subtypes of PTCL did not show statistical significance in the stratification of LMR in our study, either by Pearson's chi square test (P=0.330) or performing bonferroni-post-hoc-correction (P=0.570). Although the difference of case typing in PMR was statistically significant through Pearson's chi square test (P=0.018), the difference was not statistically significant in bonferroni-post-hoc-correction (P=0.139). The median age at diagnosis was 55 years (rang: 15-84 years), and among them, 36% of the elderly patients were over 60 years old. The ratio of male to female was close to 2:1. About 81.3% of patients were in stage III-IV and 58.5% of them had B symptoms. At the first diagnosis, 32.3% of patients had albumin below 35 g/L, and 64.6% of them were infected with Epstein-Barr virus (EBV). In addition, 163 patients had more than one extra-nodal site involved. The serum lactic dehydrogenase (LDH) and beta-2 microglobulin (β2-MG) levels were increased in 64% of the patients, respectively. All patients received at least two cycles of chemotherapy. Except for all ENKTL patients received the protocol containing Pegaspargase. The rest of patients included in this study were treated with CHOP (cyclophosphamide-doxorubicin-vincristine-prednisone) or CHOP-like chemotherapy. Furthermore, 36 patients proceeded to hemopoietic stem cell transplantation, in which 24 of them accepted autologous stem cell transplantation. 3.2 The cut-off values and the association of LMR/PMR with clinical parameters and complete response (CR) The ROC curve was generated to select the appropriate cutoff values for LMR and PMR based on the survival analysis (Figure 1). For LMR, the area under curve (AUC) was 0.734 (95% CI: 0.682-0.786), with a generated maximum joint sensitivity and specificity at the value of 1.68. In addition, for PMR the AUC was calculated to be 0.718 (95% CI: 0.664-0.772), with a generated maximum joint sensitivity and specificity at the value of 300. Table 1 compared the clinical characteristics of patients with LMR and PMR at different levels and the high group and low group were defined as being greater than the cutoff value and less or equal to than the cutoff value, respectively. Post hoc analysis demonstrated sufficient power to distinguish the significant differences (power = 0.996). Patients with LMR≤1.68 or PMR≤300, only 14.2% and 14.3% of them achieved complete response (CR) after treatment. Therefore, it is not difficult to speculate that patients with LMR≤1.68 or PMR≤300 may have poor therapeutic effect. Moreover, we found that in the low LMR and PMR groups, the proportion of patients with IPI at 3-5 points is higher. Whether in the low-risk group (IPI = 0-2) or the high-risk group of IPI (IPI = 3-5), the OS of PTCL patients with low LMR group and low PMR group were significantly lower than those of patients in the high LMR group and high PMR group (Figure 3). In univariate logistic regression analysis, lower CR rate was related to first diagnosis older than 60 years, IPI≥3, ECOG≥3, stage III-IV, B symptoms, bone marrow involvement, Albumin＜35g/L, EBV infection, Extra-nodal＞1, lymphocyte (LY)(×10 9 /L)＜0.8, monocyte (MONO)(×10 9 /L)＞1, platelet (PLT)(×10 9 /L)＜83, elevated LDH and elevated β2-MG, LMR≤1.68 and PMR≤300 (Table 2). Nevertheless, in the multivariate logistic regression analysis, only first diagnosis older than 60 years(OR=4.031, 95% CI 2.021-8.041, p＜0.001), ECOG≥3(OR=3.610, 95% CI 1.572-8.290, p=0.002), stage III-IV(OR=2.737, 95% CI 1.255-5.969, p=0.011), bone marrow involvement(OR=2.581, 95% CI 1.173-5.683, p=0.018) and EBV infection(OR=2.090, 95% CI 1.170-3.734, p=0.013) were statistically significant(Table 2). 3.3 The association of LMR/PMR with OS In our study, we analyzed the survival of low and high groups of LMR and PMR patients, and found that there were significant differences in OS between all the two groups (P＜0.001)(Figure 2). The median survival time in the groups with LMR≤1.68 and LMR＞1.68 and PMR≤300 and PMR＞300 were 5 months and 28.5 months, 6 months and 28 months, respectively. The univariate analysis showed that first diagnosis older than 60 years, IPI≥3, ECOG≥3, stage III-IV, B symptoms, bone marrow involvement, decreased albumin, EBV infection, Extra-nodal＞1, LY(×10 9 /L)＜0.8, MONO(×10 9 /L)＞1, PLT(×10 9 /L)＜83, elevated LDH, elevated β2-MG, LMR≤1.68 and PMR≤300 were prognostic indicators of OS(Table 3). Then, multivariate analysis was showed that patients with poor OS had ECOG≥3 (HR=2.351, 95% CI 1.647-3.356, p＜0.001), stage III-IV (HR=3.276, 95% CI 1.512-7.099, p=0.003), Extra-nodal＞1 (HR=1.659, 95% CI 1.125-2.445, p=0.039), LMR≤1.68 (HR=1.751, 95% CI 1.158-2.647, p=0.006), and PMR≤300 (HR=1.762, 95% CI 1.201-2.586, p=0.002). Considering the heterogeneity of PTCL, we analyzed the five common pathological subtypes separately, and found that the decrease of LMR and PMR was significantly correlated with OS except ALCL, ALK+ (Table 4, 5). May be related to the small number of this subtypes in this study. 3.4 Establishment of PBS model and its correlation with OS We compared the peripheral blood cell count of the patients at the initial stage, and scored 1 point for LMR≤1.68 and PMR≤300 respectively. The patients were divided into PBS 0, 1 and 2. 0 was divided into low-risk group, 1 was medium risk group, and 2 was high-risk group. The OS of the three groups was statistically analyzed by Kaplan Meier curve and log-rank test. It was found that the OS of low-risk, medium risk and high-risk patients was significantly different. The median OS of the three groups were 32.5 months, 13 months and 5 months respectively (P＜0.001)(Figure 4). Not only that, in the PBS high-risk group, 77.4% of the patients survived for less than 1 year, and only 13.1% survived for more than 3 years. In the low-risk group with PBS 0 score, 86% of the patients survived more than 1 year, and 43.4% of the patients survived for more than 3 years, nearly half of them. Discussion The prognosis of PTCL is poor, either in first-and second-line therapy or salvage therapy. There is an urgent need to use accurate predictive models to classify patients at risk. Among all the previously reported indices, IPI and PIT are the most commonly used. It is worth noting that there is considerable overlap in the parameters used to establish the various models and that the patients need to be evaluated by imaging, examination, bone marrow, etc. . The operations are complex, and the establishments of these scoring models are not entirely based on PTCL, so their accuracy are questionable. With the development of medical science in recent years, more and more attention had been paid to the study of tumor molecular mechanisms, especially in tumor micro-environment. Therefore, the research on PTCL has opened a new chapter. Recently, a growing body of research has consistently shown that tumor-associated inflammatory response is a key determinant of prognosis in cancer patients [16]. In previous retrospective studies, we found an association between increased serum Interleukin-10 levels and low survival and early recurrence in patients with PTCL [17]. Interleukin-10 is involved in the body's inflammatory and immune responses and plays an important role in tumors and infections. It is mainly secreted by monocytes, activated T-cells, macrophages, certain tumor cells and so on. Thus, monocyte and macrophage systems are closely related to the prognosis of PTCL. About 2-9% of peripheral leukocytes are peripheral blood monocytes (PBMC), but only 40% of them are used for monocyte circulation, while 60% of monocytes migrate [18]. However, some immature PBMC can differentiate into specialized, tissue-specific macrophages and Antigen-presenting cells (APC). Their differentiation directly determines their functions. The differentiated monocytes/macrophages (Mphi) plays a specific role in the cell mediated innate immunity against infection, immunoregulation, morphogenetic remodelling and malignancy or tissue repair [19-20]. Subsequently, macrophages respond to a wide range of chemokines and growth or differentiation factors such as CCL-2 and CSF-1 produced by tumors and stromal cells. VEGFA and EGF produced by Tumor-associated macrophages (TAMs) promote angiogenesis and tumor growth, respectively, which is consistent with the positive correlation between CD68 expression, vascular invasion and tumor length [21]. Macrophages are remarkably plastic. Depending on the stimulus that activates them, they can polarize to either type M1(causing an anti-tumor response) or type M2(causing tumor growth and progression). It had been demonstrated that the growth and survival of malignant T-cells depend on alternatively activated (M2) macrophages in the micro-environment and that the growth of alternatively activated (M2) macrophages were influenced by TAMs [22]. Yingming Zhu et al. found that LMR was associated with TILs/TAMs ratio, and that low LMR had worse OS in patients with esophageal squamous cell carcinoma [13]. It suggests that a systemic inflammatory response may reflect concurrent focal inflammation in the tumor. D.Iacono et al. retrospectively analyzed 165 patients with advanced melanoma. The severity and prognosis of the disease were assessed. The decrease of LMR suggests short OS and more distant metastatic sites in malignant melanoma [23]. Wang et al. reported 355 cases of diffuse large B-cell lymphoma (DLBCL). In the low LMR group, PFS and OS were shorter and M2-TAM content was higher. These results suggested that weak anti-tumor immunity may be an adverse prognostic factor for aggressive lymphoma, identified in high-risk patients [24]. Thus, lymphocyte counts, monocyte counts, and LMR surrogate markers of tumor micro-environment had been reported as prognostic factors for B cell lymphoma[24-26]. Similarly, recent studies had shown that both lymphocyte counts and monocyte counts could predict the clinical outcome of T-cell lymphomas[27-28]. And patients with T-cell lymphomas after autologous peripheral hematopoietic stem cell transplantation had longer OS and PFS with autograft lymphocyte-to-monocyte ratio(A-LMR) greater than or equal to 1. Compared with patients with A-LMR less than 1, the five years OS rate was 87% to 26% , and the five years PFS rate was 72% to 16% , significant difference [29]. But in our study, patients with LMR less than or equal to 1.68 had a median OS and significantly worse CR rate for treatment than patients with LMR greater than 1.68 (5 months vs. 28.5 months; 14.2% vs. 45%) . The main reasons for this difference include: first, in Luis F et al.'s study, they examined autograft lymphocyte-to-monocyte ratio(A-LMR), whereas our study examined LMR in patients'peripheral blood at the time of initial diagnosis; second, they included only 109 patients, we included 347 patients; third, they chose patients with T- cell lymphomas, and we included peripheral T-cell lymphomas, with different baseline characteristics. Megakaryocytogenesis is a process in which megakaryocytes (MK) proliferate, differentiate and mature from pluripotent hematopoietic stem cells (HSC), while platelets are formed from mature MK fragments. The average platelet count in humans is between 150×10 9 and 400×10 9 per liter, but over time, the number of individual platelets remains the same[30]. Platelets mainly participates in the organism haemostasis and the thrombosis. In recent years, there are increasing evidences that platelets and tumor cells have significant cross-communication, suggesting that they play an important role in the progression of malignant tumors, the occurrence of tumor-associated local inflammation, and cancer-associated thrombosis. On the one hand, tumors can affect the RNA profile of platelets, the number of circulating platelets and their activation status. On the other hand, tumor-induced platelets contain a large number of active biomolecules, including platelet-specific and circularly ingested biomolecules that are released upon activation of platelets and are involved in the development of malignant tumors[31]. Tissue factor (TF) has a direct pro-inflammatory effect by inducing the production of reactive oxygen species [32]. Thus, platelets are directly involved in the initiation of inflammatory responses (clotting, monocyte recruitment, activation, and matrix remodeling) by inducing additional adhesion molecules, MMPs, tissue-type plasminogen activators, and cytokines (such as MCP-1) in endothelial cells [33]. Platelets store and release CXCL12 (SDF-1), which controls the differentiation of hematopoietic progenitors into endothelial cells or macrophage-foam cells. CXCL12 binds CXCR4 and CXCR7 and regulates the functions of monocyte/macrophages. M Chatterjee et al. found that platelets and platelet-macrophage aggregates increased in peritoneal fluid following peritonitis induction in mice in vivo. Compared with peripheral blood, the relative surface expressions of CXCL12, CXCR4 and CXCR7 in infiltrated monocytes were also enhanced. Moreover, platelet CXCL12 and recombinant CXCL12 participate in the enhancement of specific induction of monocyte chemotaxis through CXCR4. Under static and dynamic arterial flow conditions, the adhesion of monocytes to the surface of immobilized CXCL12 and activated platelets rich in CXCL12 is mediated mainly through CXCR7, and is counter-regulated by neutralizing platelet-derived CXCL12. In the co-culture experiment with platelets, monocytes were mainly differentiated to CD163+ macrophages, and CD163+ macrophages weakened after blocking antibodies to CXCL12 and CXCR4/CXCR7. Therefore, platelets-derived CXCL12 can regulate mononuclear-macrophage functions through different combinations of CXCR4 and CXCR7, suggesting that it plays an important role in platelet aggregation in local inflammatory responses [34]. Platelet activation plays an important role in tumor-associated immune thrombosis and multiple metastasis. Activated platelets were known to secrete a range of inflammatory chemokines that activate inflammatory signaling pathways in white blood cells, including PAF, RANTES, CCL3, CXCL1, CXCL4 (platelet factor 4), and CXCL7 [35, 36]. Serotonin (5-hydroxytryptamine) is another platelet-releasing product that may affect monocyte function. Monocytes exposed to 5-hydroxytryptamine showed increased NF-κB activation, increased cytokine production induced by LPS, and decreased apoptosis, possibly due to changes in BCL-2 or MCL-1 expression [37]. In the past few decades, a large number of clinical studies have shown that daily aspirin can reduce the incidence, metastasis and mortality of tumors, especially for colorectal cancer [38]. Recently, Guillem Lobat P and his collaborators demonstrated in an immunodeficiency mouse model that low-dose aspirin reduces the metastasis of lung cancer by avoiding the enhanced pro-aggregation effect caused by platelet-tumor cell interaction [39]. These clinical studies have fully confirmed that platelets are closely related to the occurrence and development of tumors. In conclusion, since both host immunity and tumor micro-environment are closely related to the occurrence, development and metastasis of tumor, the combination of lymphocyte count, monocyte count and platelet count can better reflect the prognosis of tumor. LMR had been studied in many different disease settings, had been widely discussed, and had been found to predict esophageal cancer, melanoma, Hodgkin's lymphoma, multiple myeloma, and DLBCL [13,23,40-42]. However, it has never been discussed in PTCL. Platelet counts and monocyte counts had been shown to be associated with sepsis, pulmonary embolism [43-44], and so on, but no correlation between platelet counts and monocyte count ratios and tumors has been previously reported. We analyzed 347 patients with primary PTCL and found that the patients with low LMR ratio and low PMR ratio had worse response to treatment and shorter survival time. The difference were significant in low-to-moderate-risk patients with an IPI score of 0-2 and in high-to-moderate-risk patients with an IPI score of 3-5. In multivariate tests, LMR ≤ 1.68 and PMR ≤ 300 were independent risk factors for OS shortening. By integrating reduced LMR and PMR to produce a "PBS" model, newly diagnosed PTCL patients can be divided into three risk groups. Specifically, patients in the low-risk group had no abnormal blood cells and had a 3-year survival rate of 43.4% , while those in the high-risk group had a 3-year survival rate of 13.1% . Our study still has some limitations. Firstly, the retrospective study may be biased in the selection of patients. Secondly, the dynamic changes of patients during treatment did not taken into account during analysis. Third, our sample size is relatively small and lack of cytogenetic data. Another issue is the cut-off value of LMR/PMR used in clinical practice. In the past and in our study, the ROC curve based on survival was used to determine the optimal cut-off value, indicating that there was inconsistency between the centers. Therefore, further exploration and prospective trials with larger samples are needed in the future and the PBS model we established also needs further verification. Conclusions All in all, decreased LMR and PMR can be used as early prognostic indicators in PTCL patients. Moreover, we can easily detect the complete blood cell count (CBC), and use PBS model to preliminarily screen and stratify patients. It is simple, convenient and accurate to screen out patients with short lives, and formulate personalized treatment strategies. More large-sample prospective clinical trials are needed to confirm these findings in future research directions. List Of Abbreviations A bbreviations Definitions PTCL peripheral T-cell lymphoma NHL non-Hodgkin ’ s lymphoma CR complete response OS overall survival ECOG e astern cooperative oncology group LMR lymphocyte-monocyte ratio PMR platelet-monocyte ratio PBS peripheral blood score CBC blood cell count PTCL-NOS peripheral T-cell lymphoma, not otherwise specified ENKTL extra-nodal natural killer (NK)/T cell lymphoma, nasal type AITL angioimmunoblastic T-cell lymphoma ALK+ ALCL anaplastic lymphoma kinase positive anaplastic large cell lymphoma ALK- ALCL anaplastic lymphoma kinase negative anaplastic large cell lymphoma MEITL monomorphic epitheliotropic intestinal T- cell lymphoma SPTCL subcutaneous panniculitis like T-cell lymphoma MF/SS mycosisfungoides/Sezary ’ s syndrome HSTCL hepatosplenic T-cell lymphoma IPI International Prognostic Index LDH lactic dehydrogenase TAMs tumor-associated macrophages ROC receiver operating characteristic CI confidence interval EBV epstein-Barr virus β2-MG beta-2 microglobulin LY lymphocyte MONO monocyte PLT platelet PBMC peripheral blood monocytes APC a ntigen-presenting cells Mphi monocytes/macrophages DLBCL diffuse large B-cell lymphoma PFS progression free survival A-LMR autograft lymphocyte-to-monocyte ratio HSC hematopoietic stem cells TF t issue factor Declarations 7.1 Ethics approval and consent to participate All procedures involving human participants in our study were conducted in accordance with the Helsinki declaration and all patients signed informed consents. 7.2 Consent for publication All authors agreed to publish this manuscript. There is no copyright conflict. 7.3 Availability of data and materials All data included in our manuscript were real clinical data. However, because this was a retrospective clinical study, the original blood samples have been unable to obtain, so the data used were all obtained from the previous patients' in-hospital tests, without repeated tests. 7.4 Competing interests There is no conflict of interest between the authors. 7.5 Funding Not applicable 7.6 Authors' contributions Wanzhuo Xie designed the study. Yan Zhang, Yuanfei Shi, Xiaolong Zheng, Lihong Shou, Qiu Fang, Huafei Shen, Mingyu Zhu, Xin Huang, Jiansong Huang, Li Li, De Zhou, Lixia Zhu, Jingjing Zhu, Xiujin Ye and Jie Jin collected the patients’ material. Yan Zhang and Yuanfei Shi analyzed data and wrote the paper. 7.7 Acknowledgements The authors thank the practitioners who helped to collect and sort out the patient’ information and follow-up and thank the patients for allowing us to analyze their data. 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Characteristic Total LMR ≤ 1.68 LMR ＞ 1.68 PMR ≤ 300 PMR ＞ 300 （ n=347 ） （ n=127 ） （ n=220 ） p Value （ n=126 ） （ n=221 ） p Value Age 0.063 0.202 ＜ 60years 222(64.0) 73(57.5) 149(67.7) 75(59.5) 147(66.5) ≥ 60years 125(36.0) 54(42.5) 71(32.3) 51(40.5) 74(33.5) Sex 0.482 0.289 Male 229(66.0) 87(68.5) 142(64.5) 88(69.8) 141(63.8) Female 118(34.0) 40(31.5) 78(35.5) 38(30.2) 80(36.2) IPI ＜ 0.001 * ＜ 0.001 * 0-2 154(44.4) 29(22.8) 125(56.8) 27(21.4) 127(57.5) 3-5 193(55.6) 98(77.2) 95(43.2) 99(78.6) 94(42.5) ECOG ＜ 0.001 * ＜ 0.001 * 0-2 241(69.5) 66(52.0) 175(79.5) 64(50.8) 44(19.9) 3-5 106(30.5) 61(48.0) 45(20.5) 62(49.2) 177(80.1) Stage ＜ 0.001 * ＜ 0.001 * I- II 65(18.7) 1(0.8) 64(29.1) 6(4.8) 59(26.7) III-IV 282(81.3) 126(99.2) 156(70.9) 120(95.2) 162(73.3) B symptoms ＜ 0.001 * ＜ 0.001 * Yes 203(58.5) 97(76.4) 106(48.2) 94(74.6) 109(49.3) No 144(41.5) 30(23.6) 114(51.8) 32(25.4) 112(50.7) Histological 0.330 0.018 subtype PTCL,NOS 111(32.0) 45(35.4) 66(30.0) 51(40.5) 60(27.1) ENKTL 113(32.5) 32(25.2) 81(36.8) 31(24.6) 82(37.1) AITL 70(20.2) 27(21.2) 43(19.5) 29(23.0) 41(18.6) ALCL,ALK+ 20(5.8) 10(7.9) 10(4.5) 8(6.3) 12(5.4) ALCL,ALK- 21(6.0) 7(5.5) 14(6.3) 3(2.4) 18(8.1) MEITL 4(1.2) 3(2.4) 1(0.5) 1(0.8) 3(1.4) SPTCL 5(1.4) 2(1.6) 3(1.4) 1(0.8) 4(1.8) HSTCL 2(0.6) 1(0.8) 1(0.5) 2(1.6) 0(0.0) MF/SS 1(0.3) 0(0.0) 1(0.5) 0(0.0) 1(0.5) Bone marrow 0.005 * ＜ 0.001 * Involvement Yes 119(34.3) 56(44.1) 63(28.6) 75(59.5) 44(19.9) No 228(65.7) 71(55.9) 157(71.4) 51(40.5) 177(80.1) Albumin （ g/L ） ＜ 0.001 * ＜ 0.001 * ＜ 35 112(32.3) 66(52.0) 46(20.9) 64(50.8) 48(21.7) ≥ 35 235(67.7) 61(48.0) 174(79.1) 62(49.2) 173(78.3) EBV 0.165 0.074 Positive 224(64.6) 88(69.3) 136(61.8) 89(70.6) 135(61.1) N egative 123(35.4) 39(30.7) 84(38.2) 37(29.4) 86(38.9) Extra-nodal ＜ 0.001 * ＜ 0.001 * Involvement ＞ 1 163(47.0) 83(65.4) 80(36.4) 82(65.1) 81(36.7) 0, 1 184(53.0) 44(34.6) 140(63.6) 44(34.9) 140(63.3) Elevated LDH ＜ 0.001 * ＜ 0.001 * level Yes 222(64.0) 99(78.0) 123(55.9) 100(79.4) 122(55.2) No 125(36.0) 28(22.0) 97(44.1) 26(20.6) 99(44.8) Elevated ＜ 0.001 * ＜ 0.001 * β 2 -MG level Yes 222(64.0) 100(78.7) 122(55.5) 97(77.0) 125(56.6) No 125(36.0) 27(21.3) 98(44.5) 29(23.0) 96(43.4) LY( × 10 9 /L) 1.06(0.1-7.24) 0.7(0.1-2.5) 1.3(0.1-7.24) ＜ 0.001 * 0.9(0.1-6.0) 1.2(0.1-7.24) 0.182 MONO( × 10 9 /L) 0.49(0.04-1.83) 0.64(0.08-1.83) 0.45(0.04-1.34) ＜ 0.001 * 0.67(0.04-1.83) 0.42(0.04-1.19) ＜ 0.001 * PLT( × 10 9 /L) 178(2-637) 147(14-557) 195.5(2-637) 0.003 * 110(2-537) 213(44-637) ＜ 0.001 * Attainment ＜ 0.001 * ＜ 0.001 * of CR Yes 117(33.7) 18(14.2) 99(45.0) 18(14.3) 99(44.8) No 230(66.3) 109(85.8) 121(55.0) 108(85.7) 122(55.2) IPI: International Prognostic Index; ECOG:Eastern Cooperative Oncology Group; PTCL: Peripheral T-cell lymphoma; PTCL-NOS: PTCL-not otherwise specifified; ENKTL:extra-nodal NK/T-cell lymph oma, nasal type ; AITL: angioimmunoblastic T-cell lymphoma; ALCL,ALK+: anaplastic lymphoma kinase positive; ALCL,ALK − : anaplastic lymphoma kinase negative; MEITL: monomorphic epitheliotropic intestinal T-cell lymphoma; SPTCL: subcutaneous panniculitis-like T-cell lymphoma; HSTCL: hepatosplenic T-cell lymphoma; MF/SS: mycosisfungoides/Sezary ’ s syndrome; EBV: Epstein-barr virus; LDH: lactic dehydrogenase; β 2-MG: beta-2 micro-globulin; LY: lymphocyte; MONO: monocyte; PLT: platelet; CR: complete response. * Significantly different. Categorical variables are expressed in frequency and percentage (n, %); Continuous variables are expressed in median with range of minimum to maximum. Table 2. Univariate and multivariate logistic regression models of complete response (CR) in PTCL patients. univariate analysis multivariate analysis Covariate OR 95%CI p-value OR 95%CI p-value Sex, Male 1.590 1.001-2.527 0.050 Age, ≥ 60years 3.257 1.927-5.505 ＜ 0.001 * 4.031 2.021-8.041 ＜ 0.001 * IPI,3-5 5.818 3.561-9.506 ＜ 0.001 * ECOG,3-5 7.666 3.810-15.423 ＜ 0.001 * 3.610 1.572-8.290 0.002 * Stage,III-IV 7.195 3.955-13.088 ＜ 0.001 * 2.737 1.255-5.969 0.011 B symptoms 2.389 1.516-3.766 ＜ 0.001 * Bone marrow 5.613 3.077-10.237 ＜ 0.001 * 2.581 1.173-5.683 0.018 Involvement Albumin, ＜ 35g/L 2.993 1.742-5.141 ＜ 0.001 * EBV,Positive 2.233 1.409-3.541 0.001 * 2.090 1.170-3.734 0.013 Extra-nodal, ＞ 1 3.118 1.936-5.021 ＜ 0.001 * LY( × 10 9 /L) ＜ 0.8 3.565 2.042-6.224 ＜ 0.001 * MONO( × 10 9 /L) ＞ 1 2.610 0.969-7.028 0.058 PLT( × 10 9 /L) ＜ 83 7.847 2.759-22.318 ＜ 0.001 * Elevated LDH 2.263 1.429-3.585 0.001 * Elevated β 2-MG 2.672 1.683-4.243 ＜ 0.001 * LMR ≤ 1.68 4.955 2.816-8.717 ＜ 0.001 * 1.996 0.906-4.397 0.086 PMR ≤ 300 4.869 2.767-8.567 ＜ 0.001 * 1.851 0.873-3.924 0.108 OR: odds ratio; CI: confidence interval. * Significantly different. Table 3. Univariate and multivariate Cox proportional hazard regression models for overall survival (OS) in PTCL patients. univariate analysis multivariate analysis Covariate HR 95%CI p-value HR 95%CI p-value Sex, Male 1.223 0.899-1.662 0.200 Age, ≥ 60years 1.379 1.032-1.843 0.030 IPI,3-5 3.124 2.265-4.307 ＜ 0.001 * ECOG,3-5 3.775 2.820-5.054 ＜ 0.001 * 2.351 1.647-3.356 ＜ 0.001 * Stage,III-IV 7.859 3.862-15.993 ＜ 0.001 * 3.276 1.512-7.099 0.003 * B symptoms 2.101 1.542-2.862 ＜ 0.001 * Bone marrow 3.062 2.297-4.082 ＜ 0.001 * Involvement Albumin, ＜ 35g/L 2.209 1.656-2.946 ＜ 0.001 * EBV,Positive 1.390 1.024-1.887 0.035 Extra-nodal, ＞ 1 3.207 2.374-4.331 ＜ 0.001 * 1.659 1.125-2.445 0.039 LY( × 10 9 /L) ＜ 0.8 2.279 1.706-3.045 ＜ 0.001 * MONO( × 10 9 /L) ＞ 1 2.292 1.492-3.523 ＜ 0.001 * PLT( × 10 9 /L) ＜ 83 3.459 2.471-4.841 ＜ 0.001 * Elevated LDH 1.613 1.182-2.200 0.003 * Elevated β 2-MG 2.159 1.560-2.986 ＜ 0.001 * LMR ≤ 1.68 3.496 2.617-4.669 ＜ 0.001 * 1.751 1.158-2.647 0.006 * PMR ≤ 300 3.947 2.947-5.287 ＜ 0.001 * 1.762 1.201-2.586 0.002 * HR: hazard ratio; CI: confidence interval. * Significantly different. Table 4. The significance of LMR in univariate and multivariate analysis of OS in patients with five major subtypes of PTCL. Univariable analysis Multivariable analysis Histological Subtype-LMR n HR 95%CI p Value HR 95%CI p Value PTCL,NOS 111 4.525 2.738-7.475 ＜ 0.001 * 2.691 1.175-6.162 0.019 ENKTL 113 4.820 2.854-8.138 ＜ 0.001 * 1.027 0.464-2.276 0.947 AITL 70 1.908 1.013-3.591 0.045 1.785 0.844-3.775 0.129 ALCL,ALK+ 20 5.131 0.570-46.172 0.145 - - - ALCL,ALK- 21 7.102 1.740-28.982 0.006 * 1.415 0.120-16.636 0.782 HR: hazard ratio; CI: confidence interval. * Significantly different. Table 5. The significance of PMR in univariate and multivariate analysis of OS in patients with five major subtypes of PTCL. Univariable analysis Multivariable analysis Histological Subtype-PMR n HR 95%CI p Value HR 95%CI p Value PTCL,NOS 111 4.106 2.468-6.830 ＜ 0.001 * 2.010 0.941-4.293 0.071 ENKTL 113 4.732 2.777-8.064 ＜ 0.001 * 2.260 1.062-4.812 0.034 AITL 70 3.807 1.986-7.297 ＜ 0.001 * 2.962 1.313-6.684 0.009 * ALCL,ALK+ 20 8.386 0.927-75.846 0.058 - - - ALCL,ALK- 21 8.046 1.594-40.602 0.012 1.622 0.090-29.096 0.743 HR: hazard ratio; CI: confidence interval. * Significantly different. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yuanfei","middleName":"","lastName":"Shi","suffix":""},{"id":17187832,"identity":"c90fefe8-fcfd-44b8-94c8-46fb2b3dc7c0","order_by":2,"name":"Huafei Shen","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Huafei","middleName":"","lastName":"Shen","suffix":""},{"id":17187833,"identity":"c854d8ea-f83b-455a-baf0-35f9e804d4ff","order_by":3,"name":"Lihong Shou","email":"","orcid":"","institution":"Zhejiang University Huzhou Hospital: Huzhou Central Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lihong","middleName":"","lastName":"Shou","suffix":""},{"id":17187834,"identity":"4c1f5030-dd6d-4cec-bd9b-c0d6d3ee38ba","order_by":4,"name":"Qiu Fang","email":"","orcid":"","institution":"Zhejiang University Huzhou Hospital: Huzhou Central Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qiu","middleName":"","lastName":"Fang","suffix":""},{"id":17187835,"identity":"c87a6b57-b263-42b1-85f8-f1c75c74165b","order_by":5,"name":"Xiaolong Zheng","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiaolong","middleName":"","lastName":"Zheng","suffix":""},{"id":17187836,"identity":"e75f0f9a-f6bb-45b5-8376-48003061d0b0","order_by":6,"name":"Mingyu Zhu","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mingyu","middleName":"","lastName":"Zhu","suffix":""},{"id":17187837,"identity":"242bd484-b8d7-4dac-9e67-c35dec75d299","order_by":7,"name":"Xin Huang","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xin","middleName":"","lastName":"Huang","suffix":""},{"id":17187838,"identity":"f900d432-32ad-4355-8530-cda7b5133efc","order_by":8,"name":"Jiansong Huang","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated 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Zhu","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lixia","middleName":"","lastName":"Zhu","suffix":""},{"id":17187842,"identity":"800009bb-0d59-4791-88ee-0333d4705cd5","order_by":12,"name":"Jingjing Zhu","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jingjing","middleName":"","lastName":"Zhu","suffix":""},{"id":17187843,"identity":"9107f88e-f536-4420-92d4-9913b8580fb1","order_by":13,"name":"Xiujin Ye","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiujin","middleName":"","lastName":"Ye","suffix":""},{"id":17187844,"identity":"0ea6d4ef-6c78-4ae9-bd2f-b1bb00e22f34","order_by":14,"name":"Jie Jin","email":"","orcid":"","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jie","middleName":"","lastName":"Jin","suffix":""},{"id":17187845,"identity":"d3d1a116-2013-430c-9648-135f6e55a5b4","order_by":15,"name":"Wanzhuo Xie","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA6klEQVRIiWNgGAWjYDACZgiVAGQdYJAAMQ8Qr4UtgUgtDHAtPAYQJiEtBseZj0n83FGXZ3C85/MHyzYGOb4bCYyfC/BokWxmS5PsPcNWbHDm7AYDyTYGY8kbCczSM/Bo4WfmMbvB28aTuOFG7oYEoBYgI4GNmQePFjZm/m83/7ZJAFXmPDgA1FJPUAvQFrbbvG0GIC2MDUAtCQaEtAD9Yv5bti0hceaZY8YMEuckDGeeedgsjU+LwfnDjw3fttUl9h1vfvxZosxGnu948sHP+LSgAGYJcGQyNhCrAaj2A/FqR8EoGAWjYAQBAB9OSrjm868FAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-0966-5581","institution":"First Hospital of Zhejiang Province: Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Wanzhuo","middleName":"","lastName":"Xie","suffix":""}],"badges":[],"createdAt":"2020-12-17 16:54:53","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-130878/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-130878/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":7164551,"identity":"fcd16510-e9b0-4105-b2c0-efe5f0dbb0d0","added_by":"auto","created_at":"2021-03-19 21:14:05","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":20730,"visible":true,"origin":"","legend":"Receiver operating characteristic (ROC) curves of LMR and PMR of patients with PTCL. The AUC of LMR and PMR were 0.734 (95% CI: 0.682-0.786), 0.718(95% CI: 0.664-0.772).","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-130878/v2/17100282184543ccf53b3c04.png"},{"id":7164368,"identity":"7e6b9bc4-2d1a-4da2-8e08-bba766b6edab","added_by":"auto","created_at":"2021-03-19 21:11:04","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":27766,"visible":true,"origin":"","legend":"OS: Overall survival. (A) OS for different levels of LMR; (B) OS for different levels of PMR.","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-130878/v2/c1583be6ba51edcd528804c2.png"},{"id":7164544,"identity":"2d3eab60-bfa0-40d9-8d39-9167bc434f4f","added_by":"auto","created_at":"2021-03-19 21:14:04","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":47784,"visible":true,"origin":"","legend":"OS for different IPI risk stratification of PTCL patients. (A)OS of patients with different LMR levels in group of IPI score 0-2; (B)OS of patients with different PMR levels in group of IPI score 0-2; (C)OS of patients with different LMR levels in group of IPI score 3-5; (D)OS of patients with different PMR levels in group of IPI score 3-5.","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-130878/v2/a181ab7fdcab8d1df9750e97.png"},{"id":7164547,"identity":"34130c3d-2ad5-4441-8dc1-7c7faa9fb1dd","added_by":"auto","created_at":"2021-03-19 21:14:04","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":19175,"visible":true,"origin":"","legend":"Prognostic PBS model in OS of Peripheral T-cell lymphoma. Abbreviation: PBS, Peripheral Blood Score.","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-130878/v2/7970eb1bd7e1456a3a87deee.png"},{"id":13681710,"identity":"c7188eb0-72c9-4c9a-ac0e-a05a70b4aaec","added_by":"auto","created_at":"2021-09-17 11:53:02","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":394832,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-130878/v2/c957fed4-bdeb-4b12-9e5f-ded259879911.pdf"}],"financialInterests":"","formattedTitle":"Decreased peripheral blood lymphocyte-monocyte ratio and platelet-monocyte ratio and the Peripheral Blood Score model predict poor survival in peripheral T-cell lymphoma patients","fulltext":[{"header":"Introduction","content":"\u003cp\u003ePeripheral T-cell lymphoma(PTCL) is a group of rare hematological malignancies with heterogeneous morphological and biological characteristics. The overall manifestations are high invasiveness, short survival and poor prognosis. The total incidence rate is 0.5-2, per 100000 persons per year, and account for about 10% of all non-Hodgkin\u0026rsquo;s lymphomas (NHL) in Western countries[1]. However, the incidence of PTCL in Asia is higher, accounting for 25%-30% of NHL in China[2]. Nowadays, the internationally recommended first line therapy is still anthracycline-based chemotherapy. But the complete response (CR) rate after chemotherapy is only 40%-60% , with overall survival (OS) of 30-40% . Most patients face the problem of short-term recurrence [3]. And the recurrence or progression of the lack of effective treatment measures [4-5].\u003c/p\u003e\n\u003cp\u003eAccording to the WHO classification, PTCL can be further divided into many pathological subtypes. The most common subtypes include PTCL-not otherwise specified (PTCL-NOS), extra-nodal natural killer (NK)/T cell lymphoma, nasal type (ENKTL), angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ ALCL) and anaplastic lymphoma kinase negative anaplastic large cell lymphoma (ALK- ALCL) [6]. In addition, there are some rare subtypes, such as monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL), subcutaneous panniculitis like T-cell lymphoma(SPTCL), mycosisfungoides/Sezary\u0026rsquo;s syndrome(MF/SS), Hepatosplenic T-cell lymphoma (HSTCL) and so on. Due to its rarity and heterogeneity, the prognosis of PTCL are less studied.\u003c/p\u003e\n\u003cp\u003eInternational Prognostic Index (IPI) confirmed its usefulness for PTCL including age, Eastern Cooperative Oncology Group (ECOG), Ann Arbor staging, \u0026nbsp;lactic dehydrogenase (LDH) and extra-nodal invasion [3]. The Intergruppo Italiano Linfomi (now Fondazione Italiana linfomi, FIL) performed a large study in the 1990s on 385 patients diagnosed and treated. Based on this study, they identified a prognostic model, the Prognostic Index for PTCL-unspecified (PIT). The results showed that age, ECOG, LDH and bone-marrow involvement were independent predictors of OS and they confirmed that the PIT was slightly more effective than the IPI in PTCL-NOS patients[7]. But even so, these scoring systems are relatively complex and need to be evaluated from multiple aspects. Therefore, our study found that through the determination of peripheral blood lymphocyte-monocyte count ratio and platelet-monocyte count ratio could be simple and effective to screen out high-risk patients.\u003c/p\u003e\n\u003cp\u003eTumor micro-environment, host immunity and systemic inflammatory response are the key factors that determine the clinical course and prognosis of tumor patients. More and more studies found tumor-associated macrophages (TAMs) are associated with poor clinical prognosis of a variety of tumors, including colon cancer, thyroid cancer and Burkitt\u0026rsquo;s lymphoma by promoting angiogenesis, local invasion and metastasis[8-10]. Moreover, it has been confirmed that the growth and survival of malignant T cells depend on alternatively activated (M2) macrophages in micro-environment, and the growth of alternatively activated (M2) macrophages are affected by TAMs [11-12]. Yingming Zhu et al. found that serum monocytes were locally absorbed and differentiated into macrophages after tumor invasion, and reacted to a wide range of chemokines and growth or differentiation factors such as CCL-2 and CSF-1 produced by tumor and stromal cells, and further confirmed the correlation between LMR and TILs / TAMs ratio[13].\u003c/p\u003e\n\u003cp\u003eIncreasing evidence indicates that platelets play several roles in the progression of malignancies and in cancer-associated thrombosis. A notable cross-communication exists between platelets and cancer cells[14]. CXCL12 promoted monocytes and M1-M2 macrophages to phagocytic apoptosis platelets, and promoted their differentiation into foam cells through CXCR4 and CXCR7. Therefore, platelet derived CXCL12 could regulate monocyte macrophage functions through the different binding of CXCR4 and CXCR7, which indicated that they played an important role in the inflammatory reaction of platelet aggregation site[15]. Our study is the first time to discuss the relationship between PMR, LMR and prognosis of PTCL. We found that the decreased of PMR and LMR were closely related to the low survival of PTCL. On this basis, we established a peripheral blood score (PBS) model to identify high-risk patients early.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003e2.1 Patients and characteristics\u003c/p\u003e\n\u003cp\u003eThis is a single center retrospective study. A total of 347 patients with PTCL newly diagnosed in the First Affiliated Hospital of Zhejiang University School of Medicine from January 2011 to October 2019 were included. The final observation time was January 2020, and the median follow-up time was 18 months (rang: 0-108 months). The inclusion criteria were as follows: (1) Age \u0026ge;15 years; (2) The pathological diagnosis was consistent with PTCL; (3) Newly diagnosed and no chemotherapy before clinical data were collected; (4) Complete clinical data; (5) At least two cycles of treatment were given. Although the treatment plan were not completely unified, all the patients in our study received cyclophosphamide-doxorubicin-vincristine-prednisone (CHOP) or CHOP-like chemotherapy regimen, and all ENKTL patients were treated with chemotherapy combined with Pegaspargase. All procedures involving human participants in our study were conducted in accordance with the Helsinki declaration.\u003c/p\u003e\n\u003cp\u003eWe collected the medical records, physical examinations, laboratory results, pathological reports and radiological results of these patients through electronic medical records, and re analyzed the clinical data of them. All baseline data are presented in Table 1. Follow-up was performed by making phone calls. The absolute counts of lymphocytes, monocytes and platelets were obtained from a standard complete blood count (CBC) performed at diagnosis. LMR was the absolute count of lymphocyte divided by the absolute count of monocyte. PMR was the ratio of platelet absolute count to monocyte absolute count. OS was defined as the time from diagnosis to death for any reasons or last follow-up.\u003c/p\u003e\n\u003cp\u003e2.2 Cut-off value for LMR/PMR\u003c/p\u003e\n\u003cp\u003eThe optimal cut-off of LMR and PMR were obtained by calculating the area under the curve by receiver operating characteristic (ROC) curve analysis.\u003c/p\u003e\n\u003cp\u003e2.3 Statistical analysis\u003c/p\u003e\n\u003cp\u003ePost hoc power analyses were conducted with GPOWER (Faul, Erdfelder, Lang, \u0026amp; Buchner, 2007) in order to estimate the probability of occurrence of effects in the sample. Through the normal distribution test, the continuous variables included in this study all conform to the normal distribution. The continuous variables such as lymphocyte count, monocyte count and platelet count were shown as median with range and were compared by Mann-Whitney U-test. Other continuous variables were grouped according to the usual clinical threshold and were presented as frequencies and percentages (n, %) in company with categorical variables. All hierarchical and categorical variables were compared by Pearson's chi-square test. Among them, histological subtypes were performed bonferroni-post-hoc-correction. Kaplan-Meier curve was used to analyze OS and log-rank test was used for comparison. Univariate and multivariate logistic regression models were used to evaluate the correlation between clinical variables and complete remission (CR). Cox proportional hazard regression model was used to analyze univariate and multivariate of OS. Statistical analysis was performed by spss23.0 software package. In all comparisons, the results were considered to be statistically significant when the p value was \u0026lt; 0.05, and 95% confidence interval (CI) was given.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e3.1 Patients Characteristics\u003c/p\u003e\n\u003cp\u003eAccording to the admission conditions, we enrolled 347 patients with newly diagnosed PTCL for analysis. The clinical characteristics and laboratory data were listed in Table 1. The four most common subtypes of PTCL-NOS, ENKTL, AITL and ALCL accounted for 32.0%, 32.5%, 20.2% and 11.8%, respectively. Other rare subtypes including MEITL, SPTCL, HSTCL and MF/SS accounted for 3.5% totally. However, the different subtypes of PTCL did not show statistical significance in the stratification of LMR in our study, either by Pearson's chi square test (P=0.330) or performing bonferroni-post-hoc-correction (P=0.570). Although the difference of case typing in PMR was statistically significant through Pearson's chi square test (P=0.018), the difference was not statistically significant in bonferroni-post-hoc-correction (P=0.139). The median age at diagnosis was 55 years (rang: 15-84 years), and among them, 36% of the elderly patients were over 60 years old. The ratio of male to female was close to 2:1. About 81.3% of patients were in stage III-IV and 58.5% of them had B symptoms. At the first diagnosis, 32.3% of patients had albumin below 35 g/L, and 64.6% of them were infected with Epstein-Barr virus (EBV). In addition, 163 patients had more than one extra-nodal site involved. The serum lactic dehydrogenase (LDH) and beta-2 microglobulin (\u0026beta;2-MG) levels were increased in 64% of the patients, respectively.\u003c/p\u003e\n\u003cp\u003eAll patients received at least two cycles of chemotherapy. Except for all ENKTL patients received the protocol containing Pegaspargase. The rest of patients included in this study were treated with CHOP (cyclophosphamide-doxorubicin-vincristine-prednisone) or CHOP-like chemotherapy. Furthermore, 36 patients proceeded to hemopoietic stem cell transplantation, in which 24 of them accepted autologous stem cell transplantation.\u003c/p\u003e\n\u003cp\u003e3.2 The cut-off values and the association of LMR/PMR with clinical parameters and complete response (CR)\u003c/p\u003e\n\u003cp\u003eThe ROC curve was generated to select the appropriate cutoff values for LMR and PMR based on the survival analysis (Figure 1). For LMR, the area under curve (AUC) was 0.734 (95% CI: 0.682-0.786), with a generated maximum joint sensitivity and specificity at the value of 1.68. In addition, for PMR the AUC was calculated to be 0.718 (95% CI: 0.664-0.772), with a generated maximum joint sensitivity and specificity at the value of 300. Table 1 compared the clinical characteristics of patients with LMR and PMR at different levels and the high group and low group were defined as being greater than the cutoff value and less or equal to than the cutoff value, respectively. Post hoc analysis demonstrated sufficient power to distinguish the significant differences (power = 0.996). Patients with LMR\u0026le;1.68 or PMR\u0026le;300, only 14.2% and 14.3% of them achieved complete response (CR) after treatment. Therefore, it is not difficult to speculate that patients with LMR\u0026le;1.68 or PMR\u0026le;300 may have poor therapeutic effect. Moreover, we found that in the low LMR and PMR groups, the proportion of patients with IPI at 3-5 points is higher. Whether in the low-risk group (IPI = 0-2) or the high-risk group of IPI (IPI = 3-5), the OS of PTCL patients with low LMR group and low PMR group were significantly lower than those of patients in the high LMR group and high PMR group (Figure 3).\u003c/p\u003e\n\u003cp\u003eIn univariate logistic regression analysis, lower CR rate was related to first diagnosis older than 60 years, IPI\u0026ge;3, ECOG\u0026ge;3, stage III-IV, B symptoms, bone marrow involvement, Albumin＜35g/L, EBV infection, Extra-nodal＞1, lymphocyte (LY)(\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L)＜0.8, monocyte (MONO)(\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L)＞1, platelet (PLT)(\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L)＜83, elevated LDH and elevated \u0026beta;2-MG, LMR\u0026le;1.68 and PMR\u0026le;300 (Table 2). Nevertheless, in the multivariate logistic regression analysis, only first diagnosis older than 60 years(OR=4.031, 95% CI 2.021-8.041, p＜0.001), ECOG\u0026ge;3(OR=3.610, 95% CI 1.572-8.290, p=0.002), stage III-IV(OR=2.737, 95% CI 1.255-5.969, p=0.011), bone marrow involvement(OR=2.581, 95% CI 1.173-5.683, p=0.018) and EBV infection(OR=2.090, 95% CI 1.170-3.734, p=0.013) were statistically significant(Table 2).\u003c/p\u003e\n\u003cp\u003e3.3 The association of LMR/PMR with OS\u003c/p\u003e\n\u003cp\u003eIn our study, we analyzed the survival of low and high groups of LMR and PMR patients, and found that there were significant differences in OS between all the two groups (P＜0.001)(Figure 2). The median survival time in the groups with LMR\u0026le;1.68 and LMR＞1.68 and PMR\u0026le;300 and PMR＞300 were 5 months and 28.5 months, 6 months and 28 months, respectively. The univariate analysis showed that first diagnosis older than 60 years, IPI\u0026ge;3, ECOG\u0026ge;3, stage III-IV, B symptoms, bone marrow involvement, decreased albumin, EBV infection, Extra-nodal＞1, LY(\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L)＜0.8, MONO(\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L)＞1, PLT(\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L)＜83, elevated LDH, elevated \u0026beta;2-MG, \u0026nbsp;LMR\u0026le;1.68 and PMR\u0026le;300 were prognostic indicators of OS(Table 3). Then, multivariate analysis was showed that patients with poor OS had ECOG\u0026ge;3 (HR=2.351, 95% CI 1.647-3.356, p＜0.001), stage III-IV (HR=3.276, 95% CI 1.512-7.099, p=0.003), Extra-nodal＞1 (HR=1.659, 95% CI 1.125-2.445, p=0.039), LMR\u0026le;1.68 (HR=1.751, 95% CI 1.158-2.647, p=0.006), and PMR\u0026le;300 (HR=1.762, 95% CI 1.201-2.586, p=0.002).\u003c/p\u003e\n\u003cp\u003eConsidering the heterogeneity of PTCL, we analyzed the five common pathological subtypes separately, and found that the decrease of LMR and PMR was significantly correlated with OS except ALCL, ALK+ (Table 4, 5). May be related to the small number of this subtypes in this study.\u003c/p\u003e\n\u003cp\u003e3.4 Establishment of PBS model and its correlation with OS\u003c/p\u003e\n\u003cp\u003eWe compared the peripheral blood cell count of the patients at the initial stage, and scored 1 point for LMR\u0026le;1.68 and PMR\u0026le;300 respectively. The patients were divided into PBS 0, 1 and 2. 0 was divided into low-risk group, 1 was medium risk group, and 2 was high-risk group. The OS of the three groups was statistically analyzed by Kaplan Meier curve and log-rank test. It was found that the OS of low-risk, medium risk and high-risk patients was significantly different. The median OS of the three groups were 32.5 months, 13 months and 5 months respectively (P＜0.001)(Figure 4). Not only that, in the PBS high-risk group, 77.4% of the patients survived for less than 1 year, and only 13.1% survived for more than 3 years. In the low-risk group with PBS 0 score, 86% of the patients survived more than 1 year, and 43.4% of the patients survived for more than 3 years, nearly half of them.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe prognosis of PTCL is poor, either in first-and second-line therapy or salvage therapy. There is an urgent need to use accurate predictive models to classify patients at risk. Among all the previously reported indices, IPI and PIT are the most commonly used. It is worth noting that there is considerable overlap in the parameters used to establish the various models and that the patients need to be evaluated by imaging, examination, bone marrow, etc. . The operations are complex, and the establishments of these scoring models are not entirely based on PTCL, so their accuracy are questionable.\u003c/p\u003e\n\u003cp\u003eWith the development of medical science in recent years, more and more attention had been paid to the study of tumor molecular mechanisms, especially in tumor micro-environment. Therefore, the research on PTCL has opened a new chapter.\u003c/p\u003e\n\u003cp\u003eRecently, a growing body of research has consistently shown that tumor-associated inflammatory response is a key determinant of prognosis in cancer patients [16]. In previous retrospective studies, we found an association between increased serum Interleukin-10 levels and low survival and early recurrence in patients with PTCL [17]. Interleukin-10 is involved in the body's inflammatory and immune responses and plays an important role in tumors and infections. It is mainly secreted by monocytes, activated T-cells, macrophages, certain tumor cells and so on. Thus, monocyte and macrophage systems are closely related to the prognosis of PTCL. About 2-9% of peripheral leukocytes are peripheral blood monocytes (PBMC), but only 40% of them are used for monocyte circulation, while 60% of monocytes migrate [18]. However, some immature PBMC can differentiate into specialized, tissue-specific macrophages and Antigen-presenting cells (APC). Their differentiation directly determines their functions. The differentiated monocytes/macrophages (Mphi) plays a specific role in the cell mediated innate immunity against infection, immunoregulation, morphogenetic remodelling and malignancy or tissue repair [19-20]. Subsequently, macrophages respond to a wide range of chemokines and growth or differentiation factors such as CCL-2 and CSF-1 produced by tumors and stromal cells. VEGFA and EGF produced by Tumor-associated macrophages (TAMs) promote angiogenesis and tumor growth, respectively, which is consistent with the positive correlation between CD68 expression, vascular invasion and tumor length [21]. Macrophages are remarkably plastic. Depending on the stimulus that activates them, they can polarize to either type M1(causing an anti-tumor response) or type M2(causing tumor growth and progression). It had been demonstrated that the growth and survival of malignant T-cells depend on alternatively activated (M2) macrophages in the micro-environment and that the growth of alternatively activated (M2) macrophages were influenced by TAMs [22]. Yingming Zhu et al. found that LMR was associated with TILs/TAMs ratio, and that low LMR had worse OS in patients with esophageal squamous cell carcinoma [13]. It suggests that a systemic inflammatory response may reflect concurrent focal inflammation in the tumor.\u003c/p\u003e\n\u003cp\u003eD.Iacono et al. retrospectively analyzed 165 patients with advanced melanoma. The severity and prognosis of the disease were assessed. The decrease of LMR suggests short OS and more distant metastatic sites in malignant melanoma [23]. Wang et al. reported 355 cases of diffuse large B-cell lymphoma (DLBCL). In the low LMR group, PFS and OS were shorter and M2-TAM content was higher. These results suggested that weak anti-tumor immunity may be an adverse prognostic factor for aggressive lymphoma, identified in high-risk patients [24]. Thus, lymphocyte counts, monocyte counts, and LMR surrogate markers of tumor micro-environment had been reported as prognostic factors for B cell lymphoma[24-26]. Similarly, recent studies had shown that both lymphocyte counts and monocyte counts could predict the clinical outcome of T-cell lymphomas[27-28]. And patients with T-cell lymphomas after autologous peripheral hematopoietic stem cell transplantation had longer OS and PFS with autograft lymphocyte-to-monocyte ratio(A-LMR) greater than or equal to 1. Compared with patients with A-LMR less than 1, the five years OS rate was 87% to 26% , and the five years PFS rate was 72% to 16% , significant difference [29]. But in our study, patients with LMR less than or equal to 1.68 had a median OS and significantly worse CR rate for treatment than patients with LMR greater than 1.68 (5 months vs. 28.5 months; 14.2% vs. 45%) . The main reasons for this difference include: first, in Luis F et al.'s study, they examined autograft lymphocyte-to-monocyte ratio(A-LMR), whereas our study examined LMR in patients'peripheral blood at the time of initial diagnosis; second, they included only 109 patients, we included 347 patients; third, they chose patients with T- cell lymphomas, and we included peripheral T-cell lymphomas, with different baseline characteristics.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Megakaryocytogenesis is a process in which megakaryocytes (MK) proliferate, differentiate and mature from pluripotent hematopoietic stem cells (HSC), while platelets are formed from mature MK fragments. The average platelet count in humans is between 150\u0026times;10\u003csup\u003e9\u003c/sup\u003e and 400\u0026times;10\u003csup\u003e9\u003c/sup\u003e per liter, but over time, the number of individual platelets remains the same[30]. Platelets mainly participates in the organism haemostasis and the thrombosis. In recent years, there are increasing evidences that platelets and tumor cells have significant cross-communication, suggesting that they play an important role in the progression of malignant tumors, the occurrence of tumor-associated local inflammation, and cancer-associated thrombosis. On the one hand, tumors can affect the RNA profile of platelets, the number of circulating platelets and their activation status. On the other hand, tumor-induced platelets contain a large number of active biomolecules, including platelet-specific and circularly ingested biomolecules that are released upon activation of platelets and are involved in the development of malignant tumors[31]. Tissue factor (TF) has a direct pro-inflammatory effect by inducing the production of reactive oxygen species [32]. Thus, platelets are directly involved in the initiation of inflammatory responses (clotting, monocyte recruitment, activation, and matrix remodeling) by inducing additional adhesion molecules, MMPs, tissue-type plasminogen activators, and cytokines (such as MCP-1) in endothelial cells [33]. Platelets store and release CXCL12 (SDF-1), which controls the differentiation of hematopoietic progenitors into endothelial cells or macrophage-foam cells. CXCL12 binds CXCR4 and CXCR7 and regulates the functions of monocyte/macrophages. M Chatterjee et al. found that platelets and platelet-macrophage aggregates increased in peritoneal fluid following peritonitis induction in mice in vivo. Compared with peripheral blood, the relative surface expressions of CXCL12, CXCR4 and CXCR7 in infiltrated monocytes were also enhanced. Moreover, platelet CXCL12 and recombinant CXCL12 participate in the enhancement of specific induction of monocyte chemotaxis through CXCR4. Under static and dynamic arterial flow conditions, the adhesion of monocytes to the surface of immobilized CXCL12 and activated platelets rich in CXCL12 is mediated mainly through CXCR7, and is counter-regulated by neutralizing platelet-derived CXCL12. In the co-culture experiment with platelets, monocytes were mainly differentiated to CD163+ macrophages, and CD163+ macrophages weakened after blocking antibodies to CXCL12 and CXCR4/CXCR7. Therefore, platelets-derived CXCL12 can regulate mononuclear-macrophage functions through different combinations of CXCR4 and CXCR7, suggesting that it plays an important role in platelet aggregation in local inflammatory responses [34].\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Platelet activation plays an important role in tumor-associated immune thrombosis and multiple metastasis. Activated platelets were known to secrete a range of inflammatory chemokines that activate inflammatory signaling pathways in white blood cells, including PAF, RANTES, CCL3, CXCL1, CXCL4 (platelet factor 4), and CXCL7 [35, 36]. Serotonin (5-hydroxytryptamine) is another platelet-releasing product that may affect monocyte function. Monocytes exposed to 5-hydroxytryptamine showed increased NF-\u0026kappa;B activation, increased cytokine production induced by LPS, and decreased apoptosis, possibly due to changes in BCL-2 or MCL-1 expression [37]. In the past few decades, a large number of clinical studies have shown that daily aspirin can reduce the incidence, metastasis and mortality of tumors, especially for colorectal cancer [38]. Recently, Guillem Lobat P and his collaborators demonstrated in an immunodeficiency mouse model that low-dose aspirin reduces the metastasis of lung cancer by avoiding the enhanced pro-aggregation effect caused by platelet-tumor cell interaction [39]. These clinical studies have fully confirmed that platelets are closely related to the occurrence and development of tumors.\u003c/p\u003e\n\u003cp\u003eIn conclusion, since both host immunity and tumor micro-environment are closely related to the occurrence, development and metastasis of tumor, the combination of lymphocyte count, monocyte count and platelet count can better reflect the prognosis of tumor. LMR had been studied in many different disease settings, had been widely discussed, and had been found to predict esophageal cancer, melanoma, Hodgkin's lymphoma, multiple myeloma, and DLBCL [13,23,40-42]. However, it has never been discussed in PTCL. Platelet counts and monocyte counts had been shown to be associated with sepsis, pulmonary embolism [43-44], and so on, but no correlation between platelet counts and monocyte count ratios and tumors has been previously reported. We analyzed 347 patients with primary PTCL and found that the patients with low LMR ratio and low PMR ratio had worse response to treatment and shorter survival time. The difference were significant in low-to-moderate-risk patients with an IPI score of 0-2 and in high-to-moderate-risk patients with an IPI score of 3-5. In multivariate tests, LMR \u0026le; 1.68 and PMR \u0026le; 300 were independent risk factors for OS shortening. By integrating reduced LMR and PMR to produce a \"PBS\" model, newly diagnosed PTCL patients can be divided into three risk groups. Specifically, patients in the low-risk group had no abnormal blood cells and had a 3-year survival rate of 43.4% , while those in the high-risk group had a 3-year survival rate of 13.1% .\u003c/p\u003e\n\u003cp\u003eOur study still has some limitations. Firstly, the retrospective study may be biased in the selection of patients. Secondly, the dynamic changes of patients during treatment did not taken into account during analysis. Third, our sample size is relatively small and lack of cytogenetic data. Another issue is the cut-off value of LMR/PMR used in clinical practice. In the past and in our study, the ROC curve based on survival was used to determine the optimal cut-off value, indicating that there was inconsistency between the centers. Therefore, further exploration and prospective trials with larger samples are needed in the future and the PBS model we established also needs further verification.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eAll in all, decreased LMR and PMR can be used as early prognostic indicators in PTCL patients. Moreover, we can easily detect the complete blood cell count (CBC), and use PBS model to preliminarily screen and stratify patients. It is simple, convenient and accurate to screen out patients with short lives, and formulate personalized treatment strategies. More large-sample prospective clinical trials are needed to confirm these findings in future research directions.\u003c/p\u003e"},{"header":"List Of Abbreviations","content":"\u003ctable style=\"width: 409.75pt; background: white; border-collapse: collapse; border: none; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"546\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 409.75pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"546\"\u003e\n\u003cp\u003eA\u003cspan style=\"color: black;\"\u003ebbreviations\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Definitions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 52.3pt;\"\u003e\n\u003ctd style=\"width: 409.75pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 52.3pt;\" width=\"546\"\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003ePTCL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; peripheral T-cell lymphoma\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eNHL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; non-Hodgkin\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026rsquo;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003es lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eCR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; complete response\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eOS\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;overall survival\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eECOG\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; e\u003c/span\u003e\u003cspan style=\"color: black;\"\u003eastern cooperative oncology group\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eLMR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"color: black;\"\u003elymphocyte-monocyte ratio\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003ePMR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"color: black;\"\u003eplatelet-monocyte ratio\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003ePBS\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; peripheral blood score\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eCBC\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; blood cell count\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003ePTCL-NOS\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; peripheral T-cell lymphoma, not otherwise specified\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eENKTL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; extra-nodal natural killer (NK)/T cell lymphoma, nasal type\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eAITL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; angioimmunoblastic T-cell lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eALK+ ALCL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; anaplastic lymphoma kinase positive anaplastic large cell lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eALK- ALCL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; anaplastic lymphoma kinase negative anaplastic large cell lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eMEITL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; monomorphic epitheliotropic intestinal T-\u003c/span\u003e\u003cspan style=\"color: black;\"\u003ecell \u003c/span\u003e\u003cspan style=\"color: black;\"\u003elymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eSPTCL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; subcutaneous panniculitis like T-cell lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eMF/SS\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"color: black;\"\u003emycosisfungoides/Sezary\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026rsquo;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003es\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e syndrome\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eHSTCL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;hepatosplenic T-cell lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eIPI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;International Prognostic Index\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eLDH\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003elactic dehydrogenase\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eTAMs\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003etumor-associated macrophages\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eROC\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;receiver operating characteristic\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eCI\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003econfidence interval\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eEBV\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;epstein-Barr virus\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003e\u0026beta;2-MG\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;beta-2 microglobulin\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eLY\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; lymphocyte\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eMONO\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; monocyte\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003ePLT\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;platelet\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003ePBMC\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003eperipheral blood monocytes\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eAPC\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;a\u003c/span\u003e\u003cspan style=\"color: black;\"\u003entigen-presenting cells\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eMphi\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003emonocytes/macrophages\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eDLBCL\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003ediffuse large B-cell lymphoma\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003ePFS\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;progression free survival\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eA-LMR\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: black;\"\u003eautograft lymphocyte-to-monocyte ratio\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #231f20;\"\u003eHSC\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;hematopoietic stem cells\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eTF\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;t\u003c/span\u003e\u003cspan style=\"color: black;\"\u003eissue factor\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e"},{"header":"Declarations","content":"\u003cp\u003e7.1 Ethics approval and consent to participate\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; All procedures involving human participants in our study were conducted in accordance with the Helsinki declaration and all patients signed informed consents.\u003c/p\u003e\n\u003cp\u003e7.2 Consent for publication\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; All authors agreed to publish this manuscript. There is no copyright conflict.\u003c/p\u003e\n\u003cp\u003e7.3 Availability of data and materials\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; All data included in our manuscript were real clinical data. However, because this was a retrospective clinical study, the original blood samples have been unable to obtain, so the data used were all obtained from the previous patients' in-hospital tests, without repeated tests.\u003c/p\u003e\n\u003cp\u003e7.4 Competing interests\u003c/p\u003e\n\u003cp\u003eThere is no conflict of interest between the authors.\u003c/p\u003e\n\u003cp\u003e7.5 Funding\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; Not applicable\u003c/p\u003e\n\u003cp\u003e7.6 Authors' contributions\u003c/p\u003e\n\u003cp\u003eWanzhuo Xie designed the study. Yan Zhang, Yuanfei Shi, Xiaolong Zheng, Lihong Shou, Qiu Fang, Huafei Shen, Mingyu Zhu, Xin Huang, Jiansong Huang, Li Li, De Zhou, Lixia Zhu, Jingjing Zhu, Xiujin Ye and Jie Jin collected the patients\u0026rsquo; material. Yan Zhang and Yuanfei Shi analyzed data and wrote the paper.\u003c/p\u003e\n\u003cp\u003e7.7 Acknowledgements\u003c/p\u003e\n\u003cp\u003eThe authors thank the practitioners who helped to collect and sort out the patient\u0026rsquo; information and follow-up and thank the patients for allowing us to analyze their data.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eA clinical evaluation of the Inernational Lymphoma Study Group classification of non-Hodgkin\u0026rsquo;s lymphoma. The Non-Hodgkin\u0026rsquo;s Lymphoma Classification Project. Blood 1997 Jun 1;89(11): 3909-39\u003c/li\u003e\n\u003cli\u003eShi Y. 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Infused autograft lymphocyte-to-monocyte ratio and survival in T-cell lymphoma post autologous peripheral blood hematopoietic stem cell transplantation. Journal of Hematology \u0026amp; Oncology,2015,DOI 10.1186/s13045-015-0178-5.\u003c/li\u003e\n\u003cli\u003eHarker LA, Roskos LK, Marzec UM, Carter RA, Cherry JK, Sundell B, Cheung EN, Terry D, Sheridan W. Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers. Blood 95, 2514-2522 (2000).\u003c/li\u003e\n\u003cli\u003eL\u0026eacute;a Plantureux, Diane M\u0026egrave;ge, Lydie Crescence, Fran\u0026ccedil;oise Dignat-George, Christophe Dubois and Laurence Panicot-Dubois.Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis.Cancers 2018, 10, 441; doi:10.3390/cancers10110441.\u003c/li\u003e\n\u003cli\u003eHerkert O, Diebold I, Brandes RP, Hess J, Busse R, Gorlach A. NADPH oxidase mediates tissue factordependent surface procoagulant activity by thrombin in human vascular smooth muscle cells. Circulation 105, 2030-2036 (2002).\u003c/li\u003e\n\u003cli\u003eMay AE, Langer H, Seizer P, Bigalke B, Lindemann S, Gawaz M. Platelet-leukocyte interactions in inflammation and atherothrombosis. Semin Thromb Hemost 33, 123-127 (2007).\u003c/li\u003e\n\u003cli\u003eM Chatterjee, SNI von Ungern-Sternberg, P Seizer, F Schlegel, M B\u0026uuml;ttcher, NA Sindhu, S M\u0026uuml;ller, A Mack and M Gawaz. Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4\u0026ndash; Cell Death and Disease (2015) 6, e1989; doi:10.1038/cddis.2015.233.\u003c/li\u003e\n\u003cli\u003eSemple, J. W., J. E. Italiano, Jr., and J. Freedman. Platelets and the immune continuum. Nat. Rev. Immunol. 2011，11: 264\u0026ndash;\u003c/li\u003e\n\u003cli\u003eKasper, B., E. Brandt, S. Brandau, and F. Petersen. Platelet factor 4 (CXC chemokine ligand 4) differentially regulates respiratory burst, survival, and cytokine expression of human monocytes by using distinct signaling pathways. J. Immunol. 2007, 179: 2584\u0026ndash;\u003c/li\u003e\n\u003cli\u003eSoga, F., N. Katoh, T. Inoue, and S. Kishimoto. Serotonin activates human monocytes and prevents apoptosis. J. Invest. Dermatol. 2007, 127: 1947\u0026ndash;\u003c/li\u003e\n\u003cli\u003eRothwell, P.M.;Wilson,M.; Price, J.F.; Belch, J.F.;Meade, T.W.;Mehta, Z. Effect of daily aspirin on risk of cancer metastasis: Astudy of incident cancers during randomised controlled trials. Lancet 2012, 379, 1591\u0026ndash;\u003c/li\u003e\n\u003cli\u003eGuillem-Llobat, P.; Dovizio, M.; Bruno, A.; Ricciotti, E.; Cufino, V.; Sacco, A.; Grande, R.; Alberti, S.; Arena, V.; Cirillo, M.; et al. Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 2016, 7, 32462-32477.\u003c/li\u003e\n\u003cli\u003eTamar Tadmor, MD; Alessia Bari, MD; Luigi Marcheselli, MS; Stefano Sacchi, MD;Ariel Aviv, MD; Luca Baldini, MD; Paolo G. Gobbi, MD; Samantha Pozzi, MD;Paola Ferri, MS; Maria Christina Cox, MD; Nicola Cascavilla, MD;Emilio Iannitto, MD; Massimo Federico, MD; and Aaron Polliack, MD.Absolute Monocyte Count and Lymphocyte-Monocyte Ratio Predict Outcome in Nodular Sclerosis Hodgkin Lymphoma: Evaluation Based on Data From 1450 Patients. Mayo Clin Proc. June 2015;90(6):756-764, doi.org/10.1016/j.mayocp.2015.03.025\u003c/li\u003e\n\u003cli\u003eT Dosani, F Covut, R Beck, JJ Driscoll, M de Lima and E Malek. Significance of the absolute lymphocyte/monocyte ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma. Blood Cancer Journal (2017) 7, e579; doi:10.1038/bcj.2017.60\u003c/li\u003e\n\u003cli\u003eLuis F. Porrata, David J. Inwards, Stephen M. Ansell, Ivana N. Micallef, Patrick B. Johnston,William J. Hogan, Svetomir N. Markovic. Infused Autograft Lymphocyte to Monocyte Ratio and Survival in Diffuse Large B Cell Lymphoma. Biol Blood Marrow Transplant 20 (2014) 1804-1812\u003c/li\u003e\n\u003cli\u003eMatthew T. Rondina, McKenzie Carlisle, Tamra Fraughton,Samuel M. Brown,Russell R. Miller III, Estelle S. Harris, Andrew S. Weyrich,Guy A. Zimmerman,Mark A. Supiano,and Colin K. Grissom. Platelet-Monocyte Aggregate Formation and Mortality Risk in Older Patients With Severe Sepsis and Septic Shock. J Gerontol A Biol Sci Med Sci. 2015 February;70(2):225-231 doi:10.1093/gerona/glu082.\u003c/li\u003e\n\u003cli\u003eAdam J. Białas, Kamil Kornicki, Maciej Ciebiada，Adam Antczak, Przemysław Sitarek, Joanna Miłkowska‑Dymanowska, Wojciech J. Piotrowski, Paweł G\u0026oacute; Monocyte to large platelet ratio as a diagnostic tool for pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Intern Med. 2018;128 (1): 15-23,doi:10.20 452/pamw.4141\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: #231f20;\"\u003eTable 1. Characteristics of 347 patients with PTCL based on the LMR and PMR.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 505.0pt; margin-left: -39.2pt; border-collapse: collapse; border: none;\" width=\"673\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 33.45pt;\"\u003e\n\u003ctd style=\"width: 505.0pt; border-top: windowtext; border-left: white; border-bottom: black; border-right: white; border-style: solid; border-width: 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 33.45pt;\" width=\"673\"\u003e\n\u003cp style=\"text-align: left;\"\u003eCharacteristic\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Total\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; LMR\u003cspan style=\"font-family: SimSun;\"\u003e\u0026le;\u003c/span\u003e1.68\u0026nbsp;\u0026nbsp;\u0026nbsp; LMR\u003cspan style=\"font-family: SimSun;\"\u003e＞\u003c/span\u003e1.68\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; PMR\u003cspan style=\"font-family: SimSun;\"\u003e\u0026le;\u003c/span\u003e300\u0026nbsp;\u0026nbsp;\u0026nbsp; PMR\u003cspan style=\"font-family: SimSun;\"\u003e＞\u003c/span\u003e300\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e（\u003c/span\u003en=347\u003cspan style=\"font-family: SimSun;\"\u003e）\u003c/span\u003e\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e（\u003c/span\u003en=127\u003cspan style=\"font-family: SimSun;\"\u003e）\u003c/span\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e（\u003c/span\u003en=220\u003cspan style=\"font-family: SimSun;\"\u003e）\u003c/span\u003e\u0026nbsp;\u0026nbsp; p Value\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e（\u003c/span\u003en=126\u003cspan style=\"font-family: SimSun;\"\u003e）\u003c/span\u003e\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e（\u003c/span\u003en=221\u003cspan style=\"font-family: SimSun;\"\u003e）\u003c/span\u003e\u0026nbsp; p Value\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 111.9pt;\"\u003e\n\u003ctd style=\"width: 505.0pt; border-top: none; border-left: solid white 1.0pt; border-bottom: solid windowtext 1.0pt; border-right: solid white 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 111.9pt;\" width=\"673\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eAge\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.063\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.202\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e60years\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 222(64.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 73(57.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 149(67.7)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 75(59.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 147(66.5)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e\u0026ge;\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e60years\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;125(36.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 54(42.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 71(32.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 51(40.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 74(33.5)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eSex\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.482\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.289\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left; text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eMale\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 229(66.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 87(68.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 142(64.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 88(69.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 141(63.8)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left; text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eFemale\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 118(34.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 40(31.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 78(35.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 38(30.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 80(36.2)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eIPI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; 0-2\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 154(44.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 29(22.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 125(56.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 27(21.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 127(57.5)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; 3-5\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 193(55.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 98(77.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95(43.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 99(78.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 94(42.5)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eECOG\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; 0-2\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 241(69.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 66(52.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 175(79.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 64(50.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 44(19.9)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; 3-5\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 106(30.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 61(48.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 45(20.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 62(49.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 177(80.1)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eStage\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: 10.5pt; text-align: left; text-indent: 0in;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eI-\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003eII\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 65(18.7)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 64(29.1)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 6(4.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 59(26.7)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: 10.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eIII-IV\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;282(81.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 126(99.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 156(70.9)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 120(95.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 162(73.3)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eB symptoms\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; Yes\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 203(58.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 97(76.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 106(48.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 94(74.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 109(49.3)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; No\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 144(41.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 30(23.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 114(51.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 32(25.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 112(50.7)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eHistological\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.330\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;0.018\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003esubtype\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; PTCL,NOS\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 111(32.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 45(35.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 66(30.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 51(40.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 60(27.1)\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; ENKTL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 113(32.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 32(25.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 81(36.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 31(24.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 82(37.1)\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; AITL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;70(20.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 27(21.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 43(19.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 29(23.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 41(18.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; ALCL,ALK+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 20(5.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 10(7.9)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 10(4.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 8(6.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 12(5.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; ALCL,ALK-\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 21(6.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 7(5.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 14(6.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3(2.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 18(8.1)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; MEITL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4(1.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3(2.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3(1.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; SPTCL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 5(1.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2(1.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3(1.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.8)\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;4(1.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; HSTCL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2(0.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2(1.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0(0.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; MF/SS\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0(0.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0(0.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1(0.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eBone marrow\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;0.005\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eInvolvement\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; Yes\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 119(34.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 56(44.1)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 63(28.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 75(59.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 44(19.9)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; No\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 228(65.7)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 71(55.9)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 157(71.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 51(40.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 177(80.1)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eAlbumin\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003eg/L\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e35\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 112(32.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 66(52.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 46(20.9)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 64(50.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 48(21.7)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e\u0026ge;\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e35\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 235(67.7)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 61(48.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 174(79.1)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 62(49.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 173(78.3)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eEBV\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.165\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.074\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; Positive\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;224(64.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 88(69.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 136(61.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 89(70.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 135(61.1)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; N\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003eegative\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 123(35.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 39(30.7)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 84(38.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 37(29.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 86(38.9)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eExtra-nodal\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eInvolvement\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e1\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 163(47.0)\u0026nbsp;\u0026nbsp;\u0026nbsp; 83(65.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 80(36.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 82(65.1)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 81(36.7)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp; 0, 1\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 184(53.0)\u0026nbsp;\u0026nbsp;\u0026nbsp; 44(34.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 140(63.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 44(34.9)\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;140(63.3)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eElevated LDH\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003elevel\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; Yes\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 222(64.0)\u0026nbsp;\u0026nbsp;\u0026nbsp; 99(78.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 123(55.9)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 100(79.4)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 122(55.2)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; No\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 125(36.0)\u0026nbsp;\u0026nbsp;\u0026nbsp; 28(22.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 97(44.1)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 26(20.6)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 99(44.8)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eElevated\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e\u0026beta;\u003c/span\u003e\u003csub\u003e\u003cspan style=\"font-size: 9pt;\"\u003e2\u003c/span\u003e\u003c/sub\u003e\u003cspan style=\"font-size: 9pt;\"\u003e-MG level\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; Yes\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 222(64.0)\u0026nbsp;\u0026nbsp; 100(78.7)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 122(55.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 97(77.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 125(56.6)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; No\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 125(36.0)\u0026nbsp;\u0026nbsp;\u0026nbsp; 27(21.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 98(44.5)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 29(23.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 96(43.4)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eLY(\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.06(0.1-7.24)\u0026nbsp; 0.7(0.1-2.5)\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.3(0.1-7.24)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.9(0.1-6.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.2(0.1-7.24)\u0026nbsp;\u0026nbsp; 0.182\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eMONO(\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.49(0.04-1.83) 0.64(0.08-1.83) 0.45(0.04-1.34)\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.67(0.04-1.83)\u0026nbsp; 0.42(0.04-1.19) \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003ePLT(\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 178(2-637)\u0026nbsp;\u0026nbsp;\u0026nbsp; 147(14-557)\u0026nbsp;\u0026nbsp;\u0026nbsp; 195.5(2-637)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.003\u003csup\u003e* \u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;110(2-537)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 213(44-637)\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eAttainment \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003cspan style=\"font-size: 9pt; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eof CR\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; Yes\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 117(33.7)\u0026nbsp;\u0026nbsp;\u0026nbsp; 18(14.2)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 99(45.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 18(14.3)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 99(44.8)\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003e\u0026nbsp; No\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 230(66.3)\u0026nbsp;\u0026nbsp; 109(85.8)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 121(55.0)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 108(85.7)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 122(55.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9pt;\"\u003eIPI: International Prognostic Index; ECOG:Eastern Cooperative Oncology Group; PTCL: Peripheral T-cell lymphoma; PTCL-NOS: PTCL-not otherwise specifified; ENKTL:extra-nodal NK/T-cell lymph\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003eoma, nasal type ; AITL: angioimmunoblastic T-cell lymphoma; ALCL,ALK+: anaplastic lymphoma kinase positive; ALCL,ALK\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: SimSun;\"\u003e\u0026minus;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003e: anaplastic lymphoma kinase negative; MEITL: \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003emonomorphic epitheliotropic intestinal T-cell lymphoma; SPTCL: subcutaneous panniculitis-like T-cell lymphoma; HSTCL: hepatosplenic T-cell lymphoma; MF/SS: mycosisfungoides/Sezary\u003c/span\u003e\u0026rsquo;\u003cspan style=\"font-size: 9.0pt;\"\u003es syndrome; \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003eEBV: Epstein-barr virus; LDH: lactic dehydrogenase; \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: SimSun;\"\u003e\u0026beta;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003e2-MG: beta-2 micro-globulin; LY: lymphocyte; MONO: monocyte; PLT: platelet; CR: complete response.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003eSignificantly different.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003eCategorical variables are expressed in frequency and percentage (n, %); \u003c/span\u003e\u003cspan style=\"font-size: 9pt;\"\u003eContinuous variables \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003eare expressed in median with range of minimum to maximum.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"tab-stops: 15.6pt;\"\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003eTable 2. Univariate and multivariate logistic regression models of complete response (CR) in PTCL patients.\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 426.1pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"568\"\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; univariate analysis\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; multivariate analysis\u003c/p\u003e\n\u003cp style=\"text-indent: 10.5pt;\"\u003eCovariate\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; OR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; p-value\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; OR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; p-value\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 212.1pt;\"\u003e\n\u003ctd style=\"width: 426.1pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 212.1pt;\" width=\"568\"\u003e\n\u003cp\u003eSex, Male\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.590\u0026nbsp; 1.001-2.527\u0026nbsp;\u0026nbsp; 0.050\u003c/p\u003e\n\u003cp\u003eAge,\u003cspan style=\"font-family: SimSun;\"\u003e\u0026ge;\u003c/span\u003e60years\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.257\u0026nbsp; 1.927-5.505\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4.031\u0026nbsp; 2.021-8.041\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIPI,3-5\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 5.818\u0026nbsp; 3.561-9.506\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eECOG,3-5\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 7.666\u0026nbsp; 3.810-15.423 \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.610\u0026nbsp; 1.572-8.290\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.002\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eStage,III-IV\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 7.195\u0026nbsp; 3.955-13.088 \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.737\u0026nbsp; 1.255-5.969\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.011\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eB symptoms\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.389\u0026nbsp; 1.516-3.766\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eBone marrow\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 5.613\u0026nbsp; 3.077-10.237 \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.581\u0026nbsp; 1.173-5.683\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.018\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eInvolvement\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAlbumin,\u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e35g/L\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.993\u0026nbsp; 1.742-5.141\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eEBV,Positive\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;2.233\u0026nbsp;\u0026nbsp; 1.409-3.541\u0026nbsp;\u0026nbsp; 0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.090\u0026nbsp; 1.170-3.734\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.013\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eExtra-nodal,\u003cspan style=\"font-family: SimSun;\"\u003e＞\u003c/span\u003e1\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.118\u0026nbsp;\u0026nbsp; 1.936-5.021\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eLY(\u003cspan style=\"font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.8\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.565\u0026nbsp;\u0026nbsp; 2.042-6.224\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eMONO(\u003cspan style=\"font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u003cspan style=\"font-family: SimSun;\"\u003e＞\u003c/span\u003e1\u0026nbsp;\u0026nbsp; 2.610\u0026nbsp;\u0026nbsp; 0.969-7.028\u0026nbsp;\u0026nbsp; 0.058\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003ePLT(\u003cspan style=\"font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e83\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 7.847\u0026nbsp;\u0026nbsp; 2.759-22.318 \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eElevated LDH\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.263\u0026nbsp;\u0026nbsp; 1.429-3.585\u0026nbsp;\u0026nbsp; 0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eElevated \u003cspan style=\"font-family: SimSun;\"\u003e\u0026beta;\u003c/span\u003e2-MG\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.672\u0026nbsp;\u0026nbsp; 1.683-4.243\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eLMR\u003cspan style=\"font-family: SimSun;\"\u003e\u0026le;\u003c/span\u003e1.68\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4.955\u0026nbsp;\u0026nbsp; 2.816-8.717\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.996\u0026nbsp;\u0026nbsp; 0.906-4.397\u0026nbsp;\u0026nbsp; 0.086\u003c/p\u003e\n\u003cp\u003ePMR\u003cspan style=\"font-family: SimSun;\"\u003e\u0026le;\u003c/span\u003e300\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4.869\u0026nbsp;\u0026nbsp; 2.767-8.567\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.851\u0026nbsp;\u0026nbsp; 0.873-3.924\u0026nbsp;\u0026nbsp; 0.108\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 9pt;\"\u003eOR: odds ratio; CI: confidence interval.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 9pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 9pt;\"\u003eSignificantly different.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"tab-stops: 15.6pt;\"\u003e\u003cspan style=\"font-size: 9.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"tab-stops: 15.6pt;\"\u003eTable 3. Univariate and multivariate Cox proportional hazard regression models for overall survival (OS) in PTCL patients.\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 426.1pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"568\"\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; univariate analysis\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; multivariate analysis\u003c/p\u003e\n\u003cp style=\"text-indent: 10.5pt;\"\u003eCovariate\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; HR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; p-value\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; HR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; p-value\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 55.95pt;\"\u003e\n\u003ctd style=\"width: 426.1pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 55.95pt;\" width=\"568\"\u003e\n\u003cp\u003eSex, Male\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.223\u0026nbsp; 0.899-1.662\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.200\u003c/p\u003e\n\u003cp\u003eAge,\u003cspan style=\"font-family: SimSun;\"\u003e\u0026ge;\u003c/span\u003e60years\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.379\u0026nbsp; 1.032-1.843\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.030\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eIPI,3-5\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.124\u0026nbsp; 2.265-4.307\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eECOG,3-5 \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;3.775\u0026nbsp; 2.820-5.054\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.351\u0026nbsp;\u0026nbsp; 1.647-3.356\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eStage,III-IV\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 7.859\u0026nbsp; 3.862-15.993\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.276\u0026nbsp;\u0026nbsp; 1.512-7.099\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.003\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eB symptoms\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.101\u0026nbsp; 1.542-2.862\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eBone marrow\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.062\u0026nbsp; 2.297-4.082\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eInvolvement\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAlbumin,\u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e35g/L\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.209\u0026nbsp; 1.656-2.946\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eEBV,Positive\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;1.390\u0026nbsp; 1.024-1.887\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.035\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eExtra-nodal,\u003cspan style=\"font-family: SimSun;\"\u003e＞\u003c/span\u003e1\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.207\u0026nbsp; 2.374-4.331\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.659\u0026nbsp;\u0026nbsp; 1.125-2.445\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.039\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eLY(\u003cspan style=\"font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.8\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.279\u0026nbsp; 1.706-3.045\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eMONO(\u003cspan style=\"font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u003cspan style=\"font-family: SimSun;\"\u003e＞\u003c/span\u003e1\u0026nbsp; 2.292\u0026nbsp; 1.492-3.523\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003ePLT(\u003cspan style=\"font-family: SimSun;\"\u003e\u0026times;\u003c/span\u003e10\u003csup\u003e9\u003c/sup\u003e/L)\u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e83\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.459\u0026nbsp; 2.471-4.841\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eElevated LDH\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.613\u0026nbsp; 1.182-2.200\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.003\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eElevated \u003cspan style=\"font-family: SimSun;\"\u003e\u0026beta;\u003c/span\u003e2-MG\u0026nbsp;\u0026nbsp; 2.159\u0026nbsp; 1.560-2.986\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eLMR\u003cspan style=\"font-family: SimSun;\"\u003e\u0026le;\u003c/span\u003e1.68\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.496\u0026nbsp; 2.617-4.669\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.751\u0026nbsp;\u0026nbsp; 1.158-2.647 \u0026nbsp;\u0026nbsp;\u0026nbsp;0.006\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003ePMR\u003cspan style=\"font-family: SimSun;\"\u003e\u0026le;\u003c/span\u003e300\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.947\u0026nbsp; 2.947-5.287\u0026nbsp;\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.762\u0026nbsp;\u0026nbsp; 1.201-2.586\u0026nbsp;\u0026nbsp;\u0026nbsp; 0.002\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 9pt;\"\u003eHR: hazard ratio; CI: confidence interval.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 9pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 9pt;\"\u003eSignificantly different.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"tab-stops: 15.6pt;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"tab-stops: 15.6pt;\"\u003eTable 4. The significance of LMR in univariate and multivariate analysis of OS in patients with five major subtypes of PTCL.\u003c/p\u003e\n\u003ctable style=\"width: 484.0pt; border-collapse: collapse; border: none; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"645\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 36.75pt;\"\u003e\n\u003ctd style=\"width: 484.0pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 36.75pt;\" width=\"645\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Univariable analysis\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Multivariable analysis\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eHistological\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eSubtype-LMR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;n\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; HR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; p Value\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; HR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp; p Value\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 79.1pt;\"\u003e\n\u003ctd style=\"width: 484.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 79.1pt;\" width=\"645\"\u003e\n\u003cp style=\"text-align: left;\"\u003ePTCL,NOS \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;111\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4.525\u0026nbsp; 2.738-7.475\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.691\u0026nbsp; 1.175-6.162\u0026nbsp;\u0026nbsp; 0.019\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eENKTL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 113\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4.820\u0026nbsp; 2.854-8.138\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.027\u0026nbsp; 0.464-2.276\u0026nbsp;\u0026nbsp; 0.947\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAITL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 70\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.908\u0026nbsp; 1.013-3.591\u0026nbsp;\u0026nbsp; 0.045\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.785\u0026nbsp; 0.844-3.775\u0026nbsp;\u0026nbsp; 0.129\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eALCL,ALK+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 20\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 5.131\u0026nbsp; 0.570-46.172\u0026nbsp; 0.145\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; -\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; -\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; -\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eALCL,ALK-\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 21\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 7.102\u0026nbsp; 1.740-28.982\u0026nbsp; 0.006\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.415\u0026nbsp; 0.120-16.636\u0026nbsp; 0.782\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 9pt;\"\u003eHR: hazard ratio; CI: confidence interval.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 9pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 9pt;\"\u003eSignificantly different.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"tab-stops: 15.6pt;\"\u003e\u003cspan style=\"font-size: 12.0pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"tab-stops: 15.6pt;\"\u003eTable 5. The significance of PMR in univariate and multivariate analysis of OS in patients with five major subtypes of PTCL.\u003c/p\u003e\n\u003ctable style=\"width: 484.0pt; border-collapse: collapse; border: none; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"645\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 36.75pt;\"\u003e\n\u003ctd style=\"width: 484.0pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 36.75pt;\" width=\"645\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Univariable analysis\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Multivariable analysis\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eHistological\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eSubtype-PMR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;n\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; HR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; p Value\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; HR\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 95%CI\u0026nbsp;\u0026nbsp;\u0026nbsp; p Value\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 79.1pt;\"\u003e\n\u003ctd style=\"width: 484.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 79.1pt;\" width=\"645\"\u003e\n\u003cp style=\"text-align: left;\"\u003ePTCL,NOS\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 111\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4.106\u0026nbsp; 2.468-6.830\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.010\u0026nbsp; 0.941-4.293\u0026nbsp;\u0026nbsp; 0.071\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eENKTL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 113\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 4.732\u0026nbsp; 2.777-8.064\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.260\u0026nbsp; 1.062-4.812\u0026nbsp;\u0026nbsp; 0.034\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eAITL\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 70\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 3.807\u0026nbsp; 1.986-7.297\u0026nbsp; \u003cspan style=\"font-family: SimSun;\"\u003e＜\u003c/span\u003e0.001\u003csup\u003e*\u003c/sup\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 2.962\u0026nbsp; 1.313-6.684\u0026nbsp;\u0026nbsp; 0.009\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eALCL,ALK+\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 20\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 8.386\u0026nbsp; 0.927-75.846\u0026nbsp; 0.058\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; -\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; -\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; -\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003eALCL,ALK-\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 21\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 8.046\u0026nbsp; 1.594-40.602\u0026nbsp; 0.012\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 1.622\u0026nbsp;\u0026nbsp; 0.090-29.096\u0026nbsp; 0.743\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 9pt;\"\u003eHR: hazard ratio; CI: confidence interval.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 9pt;\"\u003e*\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 9pt;\"\u003eSignificantly different.\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"peripheral T-cell lymphoma, lymphocyte, platelet, monocyte, prognosis, tumor micro-environment, immunity","lastPublishedDoi":"10.21203/rs.3.rs-130878/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-130878/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground Peripheral T-cell lymphoma(PTCL) is a group of lymphoproliferative tumors originated from post-thymic T cells or mature natural killer (NK) cells. It shows highly aggressive clinical behaviour, resistance to conventional chemotherapy, and a poor prognosis. Its incidence rate in China is 1 to 2 times higher than in western countries. Therefore, optimal strategies for identifying high-risk patients are urgently needed. \u003c/p\u003e\u003cp\u003eMaterials and Methods We retrospectively studied 347 newly diagnosed PTCL patients from January 2011 to October 2019 and analyzed the relationship between peripheral blood lymphocyte-monocyte ratio (LMR) and platelet-monocyte ratio (PMR) and prognosis. The model of Peripheral Blood Score was established to screen out high-risk patients. \u003c/p\u003e\u003cp\u003eResults The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value based on survival rate. It was found that patients with PTCL with LMR ≤ 1.68 and PMR ≤ 300 had inferior overall survival (OS) and the difference was significant in both low-risk (P\u0026lt;0.001) and medium high-risk (P\u0026lt;0.001) groups of IPI score. In multivariate analysis, LMR ≤ 1.68 (HR=1.751, 95% CI 1.158-2.647, p=0.006), PMR ≤ 300 (HR=1.762, 95% CI 1.201-2.586, p=0.002), stage III-IV (HR=3.276, 95% CI 1.512-7.099, p=0.003), Eastern Cooperative Oncology Group (ECOG) score 3-5 (HR=2.351, 95% CI 1.647-3.356, p\u0026lt;0.001) and extra-nodal invasion more than one site (HR=1.659, 95% CI 1.125-2.445, p=0.039) were independently associated with short survival. LMR and PMR were integrated into \"Peripheral Blood Score (PBS)\" model. PTCL patients were divided into three risk groups: low-risk group, medium risk group and high-risk group. The 1-year OS was 86%, 55.3% and 22.6%, and the 3-year OS was 43.4%, 20% and 13.1%, respectively. \u003c/p\u003e\u003cp\u003eConclusion Overall, LMR and PMR can be used as early prognostic indicators in PTCL patients. Moreover, we can easily detect the complete blood cell count (CBC), and use PBS model to preliminarily screen and stratify patients. It is simple, convenient and accurate to screen out patients with short lives, and formulate personalized treatment strategies.\u003c/p\u003e","manuscriptTitle":"Decreased peripheral blood lymphocyte-monocyte ratio and platelet-monocyte ratio and the Peripheral Blood Score model predict poor survival in peripheral T-cell lymphoma patients","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2021-03-19 21:11:02","doi":"10.21203/rs.3.rs-130878/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-12-22 16:08:32","doi":"10.21203/rs.3.rs-130878/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ae76a107-a29a-4f67-8621-6382c7e10eb7","owner":[],"postedDate":"March 19th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":3077018,"name":"Cancer Biology"},{"id":3077019,"name":"Oncology"}],"tags":[],"updatedAt":"2021-04-10T20:40:00+00:00","versionOfRecord":[],"versionCreatedAt":"2021-03-19 21:11:02","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-130878","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-130878","identity":"rs-130878","version":["v2"]},"buildId":"cBFmMYwuxLRRLfASyISRj","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}