A Comprehensive Review of the Treatment and Management of Myofascial Pain Syndrome

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Abstract

PURPOSE OF REVIEW: Myofascial pain syndrome (MPS) is a musculoskeletal pain condition that stems from localized, taut regions of skeletal muscle and fascia, termed trigger points. The purpose of this comprehensive review is to provide updated information on prevalence, pathophysiology, and treatment modalities with a focus on interventional modalities in managing MPS. RECENT FINDINGS: Though MPS can present acutely, it frequently presents as a chronic condition, affecting up to 85% of adults during their lifetime. MPS is an often-overlooked component of pain with overarching effects on society, including patient quality of life, physical and social functioning, emotional well-being, energy, and costs on health care. The prevalence of MPS is generally increased among patients with other chronic pain disorders and has been associated with various other conditions such as bladder pain syndrome, endometriosis, and anxiety. MPS is poorly understood and remains a challenging condition to treat. Non-pharmacologic treatment modalities such as acupuncture, massage, transcutaneous electrical stimulation, and interferential current therapy may offer relief to some patients with MPS. Additional studies are warranted to get a better understanding of managing myofascial pain.

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Condition tags

endometriosis

MeSH descriptors

Myofascial Pain Syndromes Acetylcholine Release Inhibitors Acetylcholine Release Inhibitors Acupuncture Therapy Anesthetics, Local Anesthetics, Local Antidepressive Agents, Tricyclic Antidepressive Agents, Tricyclic Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Biofeedback, Psychology Botulinum Toxins, Type A Botulinum Toxins, Type A Dry Needling Electric Stimulation Therapy Humans Massage Myofascial Pain Syndromes Myofascial Pain Syndromes Myofascial Pain Syndromes

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europepmc
last seen: 2026-06-23T06:15:44.889181+00:00
pubmed
last seen: 2026-05-13T22:21:53.586419+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine