IDENTIFICATION OF A 17-HYDROXYPROGESTERONE-BINDING IMMUNOGLOBULIN IN THE SERUM OF A WOMAN WITH PERIODIC RASHES

Kerry L. Cheesman; LILIANA V. GAYNOR; Robert T. Chatterton; Ruta Radvany

doi:10.1210/jcem-55-3-597

IDENTIFICATION OF A 17-HYDROXYPROGESTERONE-BINDING IMMUNOGLOBULIN IN THE SERUM OF A WOMAN WITH PERIODIC RASHES

Kerry L. Cheesman, LILIANA V. GAYNOR, Robert T. Chatterton, Ruta Radvany

In: The Journal of Clinical Endocrinology & Metabolism · 1982 · vol. 55(3) , pp. 597–599 · doi:10.1210/jcem-55-3-597 · PMID:7096543 · W2037324477

article OA: closed CC0 ⤵ 2 in-corpus citations

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Researchers identified a 17-hydroxyprogesterone-binding IgG in the serum of a woman with periodic rashes, representing the first characterization of an antibody to an endogenous steroid in human serum.

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Abstract

A 30-year-old patient with primary infertility had a history of recurrent oral and perineal rashes that appeared just prior to the midcycle rise in basal body temperature and subsided with the onset of menses. The rashes did not appear during periods of treatment with oral contraceptives or danazol, and were suppressed by administration of cortisol. Sera obtained during the follicular and luteal phases of her cycle were found to contain a progestin-binding component with high affinity for 17-hydroxyprogesterone and a somewhat lower affinity for progesterone. Analysis of these sera showed the progestin-binding component to have properties of IgG, with an apparent binding affinity for 17-hydroxyprogesterone of 2 X 10(10) M-1. This report is the first characterization of an antibody to an endogenous steroid in human serum.

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infertility

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Cited by (1)

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,, 2019

References (9)

doi:10.1016/b978-0-12-571126-5.50005-4 via openalex
doi:10.1001/archderm.1951.01570030091012 via openalex
doi:10.1210/jcem-49-3-406 via openalex
doi:10.1016/0039-128x(78)90111-3 via openalex
doi:10.1016/0091-6749(71)90025-x via openalex
W103383249 via openalex
doi:10.1016/0003-2697(67)90297-7 via openalex
doi:10.1016/s0076-6879(69)15043-0 via openalex
doi:10.1016/0021-8707(45)90035-9 via openalex

Cited by (1)

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,, 2019

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[1] doi:10.1016/b978-0-12-571126-5.50005-4 via openalex

[2] doi:10.1001/archderm.1951.01570030091012 via openalex

[3] doi:10.1210/jcem-49-3-406 via openalex

[4] doi:10.1016/0039-128x(78)90111-3 via openalex

[5] doi:10.1016/0091-6749(71)90025-x via openalex

[6] W103383249 via openalex

[7] doi:10.1016/0003-2697(67)90297-7 via openalex

[8] doi:10.1016/s0076-6879(69)15043-0 via openalex

[9] doi:10.1016/0021-8707(45)90035-9 via openalex