Cerebellar Thrombosis Developing After Desmopressin Administration using for the diagnosis of cushing syndrome.

Abstract Cushing’s syndrome (CS) is a syndrome due to long-term glucocorticoid excess and characterized of signs and symptoms such as moon face, obesity, hypertension, fatigue, amenorrhea, hirsutismus, easy injury, striae. The most common cause of CS is iatrogenic ; when it exclused, endogenous CS occurs as a result of secretion of ACTH and CRH from pituitary and non-pituitary sources and to a lesser extent excessive secretion of glucocorticoids as a result of the pathology of the adrenal gland. Although it is a rare disease, it is an important to be diagnosed, treated and properly followed -up because it causes significant morbidity and mortality when untreated. The diagnosis of CS is based on demonstration of both physical and biochemical features of glucocorticoid excess. For this purpose, primary and secondary diagnostic tests are used. Among the secondary diagnostic tests, desmopressin test is one of the tests used in the differentiation between CS and pseudo-cushing and also in the diagnosis of cushing's disease. Studies concluded that low- desmopressin is safe and well tolerated in patients with no serious adverse effects reported yet. Here we present a case of a 41-year-old woman who developed cerebellar thrombosis shortly after desmopressin administration.