MR-gesteuerter fokussierter Ultraschall

Zusammenfassung Radiologische Standardverfahren MRT-gesteuerter hochintensiver fokussierter Ultraschall (MRgFUS bzw. MR-HIFU) ist ein nichtinvasives Verfahren zur präzisen Thermoablation eines Zielgewebes. Bei dieser Methode werden benachbarte Gewebe und Organe geschont. Methodische Innovationen Die Kombination des fokussierten Ultraschalls (FUS) mit der MRT zwecks Planung und Monitoring (nahezu) in Echtzeit sowie zur Erfolgskontrolle von Behandlungen trägt wesentlich zur Sicherheit dieser Methode bei. Bewertung MRgFUS ist klinisch v. a. zur Behandlung von symptomatischen Uterusmyomen etabliert, gefolgt von der palliativen Ablation von Knochenmetastasen. Weitere vielversprechende Anwendungsgebiete des MRgFUS sind die Adenomyose des Uterus, die Behandlung von Prostata-, Mamma- und Lebertumoren sowie der intrakranielle Einsatz. Abstract Standard radiological methods High-intensity focused ultrasound (synonyms FUS and HIFU) under magnetic resonance imaging (MRI) guidance (synonyms MRgFUS and MR-HIFU) is a completely non-invasive technology for accurate thermal ablation of a target tissue while neighboring tissues and organs are preserved. Methodical innovations The combination of FUS with MRI for planning, (near) real-time monitoring and outcome assessment of treatment markedly enhances the safety of the procedure. Achievements The MRgFUS procedure is clinically established in particular for the treatment of symptomatic uterine fibroids, followed by palliative ablation of painful bone metastases. Furthermore, promising results have been shown for the treatment of adenomyosis, malignant tumors of the prostate, breast and liver and for various intracranial applications, such as thermal ablation of brain tumors, functional neurosurgery and transient disruption of the blood-brain barrier. 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Radiologe 53, 200–208 (2013). https://doi.org/10.1007/s00117-012-2417-x Published: Issue date: DOI: https://doi.org/10.1007/s00117-012-2417-x