Expressing of Cytochrome-c, ADAM 17, Wnt-5a, and Hedgehog gene during the tissue regeneration of digit tip mice (Mus musculus) var Swiss Webster post amputation

The tissue regeneration of digit tip mice needs some proteins that play a role in overcoming the inflammatory state. The functional protein plays a role in the continuous growth of specific cells, continuous migration, functional differentiation, and tissue morphogenesis. All of the cells need energy related to cell respiration. Naturally expressing mRNA of ADAM 17, Wnt-5a, Hedgehog (HH), and Cytochrome-c (Cyt-c) reliably produced the accordance with their respective roles in each specific phase of tissue regeneration until the whole tissues formed again. The ADAM 17 gen expressed in the inflammatory phase, it positively related its essential role to the inflammatory process. Cyt-c gene expression naturally occurs throughout the tissue regeneration because of its key role in the cellular respiration. Expressed Wnt-5a gene mRNA in the granulation phase, the specific HH gene expressed after the blastema phase. Both expressed genes positively correlate with the continual growth of the digit tip mice by the specific Spearman test (p <0.05) because of their active role of cell proliferation, cell differentiation, extensive migration, and morphogenesis.