The Impact of Endothelial Cell Values on the Survival of Patients with Multiple Myeloma – A Single-Center Observational Study

Background: The aim of this study was to analyze the survival of patients with multiple myeloma depending on the value of endothelial cells involved in the process of tumor neoangiogenesis. Methods: In our non-randomized observational study, we prospectively evaluated a cohort of 74 adult patients with multiple myeloma who underwent baseline assessment of endothelial cell counts in the bone marrow, received VCD or VTD anti-myeloma therapy followed by auto PBSCT, and were then evaluated for survival during long-term follow-up. Results: The survival of myeloma patients undergoing the above therapies was analyzed, and it was shown that patients with higher endothelial cell counts had higher mortality rates during long-term follow-up. In the group of deaths, the endothelial cell count was significantly higher (p=0.0235). We also observed that patients who initially had osteolytic lesions > 2 also had higher endothelial cell counts (p=0.02120). However, analysis of endothelial cell counts in relation to survival in patients using antiangiogenic drugs showed that endothelial cell counts in this group of deaths were also significantly higher (p=0.0482) Conclusions: Patients with higher endothelial cell counts have higher mortality rates. Patients who did not receive antiangiogenic drugs from the start of therapy also had higher mortality rates during long-term follow-up.