The effect of oral contraceptives in treatment of endometriosis

Objective To observe the efficacy and side effects of oral contraceptive for treating endometriosis. Methods Clinical data was from 43 endometriosis patients with symptoms between January 2008 and December 2010.All patients were taken Drospirenone and ethinylestradiol tablets(Yasmin) on the fifth day of menstrual cycle for 9cycles.The visual analogue scale score(VAS) score,serum cancer antigen 125(CA125) level,blood routine examination,liver and kidney function、endometriosis mass and side effects were recorded before and after treatment. Results The VAS score for Dysmenorrhea,serum CA125 level after treatment was significandy lower than that of before treatment and the difference was significant(P 0.05).VAS score or pelvic pain VAS score,size of mass between before and after treatment was no significant(P 0.05).After treatment,the blood routine examination、liver and kidney function were normal level.Nobody withdrew due to adverse events.Conclusion oral contraceptive treatment for endometriosis was more effective,low side effects,especially significant for dysmenorrhea,smaller mass.