ZNF692 organizes a hub for ribosome maturation enhancing translation in rapidly proliferating cells

2022 · doi:10.1101/2022.05.26.493655
preprint OA: closed
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⚙ AI-generated summary by claude@2026-07, 2026-07-15 ⓘ

The zinc finger protein ZNF692 acts as a nucleolar scaffold coordinating final steps of 40S ribosome maturation, enhancing translation, particularly in rapidly proliferating cancer cells.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-15 · read from full text ⓘ

The study investigates how the zinc finger protein 692 (ZNF692), a MYC-induced nucleolar scaffold, coordinates the late steps of small 40S ribosome biogenesis to enhance translation in rapidly proliferating cells. Using cell-based analyses, the authors report that ZNF692 forms a complex involving rRNA, the 90S processome, and the nucleolar exosome in the granular component of the nucleolus, acting as a hub for final 18S processing and small subunit maturation. They find that cancer cells rely more heavily on ZNF692 for increased translation than normal cells. The paper’s main limitation is that it does not detail in vivo validation or patient-derived models. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Rapidly proliferating cells produce more ribosomes to translate sufficient proteins for cell growth. One of the first and rate limiting steps in translation initiation is the interaction of the small ribosomal subunit with mRNAs. Therefore, effective small ribosomal subunit biogenesis is critical for translation initiation efficiency. Here we report the identification of the zinc finger protein 692 (ZNF692), a MYC-induced nucleolar scaffold that coordinates the final steps in the biogenesis of the small 40S ribosome. ZNF692 forms a complex with rRNA, the 90S processome and the nucleolar exosome in the granular component of the nucleolus creating a hub specialized in the final steps of 18S processing and small ribosomal subunit maturation. Cancer cells are more reliant on ZNF692 for increased translation than normal cells. We propose that MYC increases translation efficiency by promoting the expression of ZNF692, adjusting the translation rate to the increase in mRNA transcription induced by MYC.
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Abstract Rapidly proliferating cells produce more ribosomes to translate sufficient proteins for cell growth. One of the first and rate limiting steps in translation initiation is the interaction of the small ribosomal subunit with mRNAs. Therefore, effective small ribosomal subunit biogenesis is critical for translation initiation efficiency. Here we report the identification of the zinc finger protein 692 (ZNF692), a MYC-induced nucleolar scaffold that coordinates the final steps in the biogenesis of the small 40S ribosome. ZNF692 forms a complex with rRNA, the 90S processome and the nucleolar exosome in the granular component of the nucleolus creating a hub specialized in the final steps of 18S processing and small ribosomal subunit maturation. Cancer cells are more reliant on ZNF692 for increased translation than normal cells. We propose that MYC increases translation efficiency by promoting the expression of ZNF692, adjusting the translation rate to the increase in mRNA transcription induced by MYC. Competing Interest Statement The authors have declared no competing interest. Footnotes Author list

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