Dyslipidemia in People Living with HIV/AIDS on Combination Antiretroviral Therapy: A Ghanaian Cross-sectional study.

Despite the several studies conducted on lipid levels among people living with HIV/AIDS on combination antiretroviral therapy (cART), drawing causal conclusions from these studies regarding the lipid profiles of individuals living with HIV/AIDS remains challenging.We analyzed the lipid profile pattern among PLWHA on cART. The study was a cross-sectional analysis at Cape Coast Teaching Hospital’s HIV/AIDS clinic. This study spanned the periods of December 2016 to May 2017 among 272 PLWHA. Data on socio-demographic characteristics, clinical history, and Cluster of differentiation (CD4) count were collected. Enzymatic-linked colorimetric methods carried out lipid analyses and a multiple logistic regression model was used to assess factors associated with dyslipidemia among cART-positive and naïve PLWHA. cART positive PLWHA had a significant increase in hypercholesterinemia [157(85.8%), p < 0.0001)], LDL-C [ 153 (84.1%), p < 0.0001)] and Non-HDL-C [167 (91.8%), p < 0.0001) than cART naive PLWHA. Being female [(adjusted odds ratio, AOR=3.10; 95% confidence interval, CI= (1.31-7.32), p 24 months) [(AOR=3.29; 95% CI = (1.05-10.30), p 500mm 3 ) contributed to high LDL-C among cART positive PLWHA [(AOR=1.96; 95% CI = (1.20-19.30), p < 0.05)]. Our findings suggest that lipid metabolism abnormalities (dyslipidemia) are common in cART-positive PLWHA. Thus, there is a need for the country’s HIV/AIDS program to establish laboratory surveillance of lipids for both cART-positive PLWHA with special attention. Supplementary Material File (manuscript.docx) - Download - 1.09 MB Information & Authors Information Version history Copyright This work is licensed under a Non Exclusive No Reuse License.

Authors Metrics & Citations Metrics Article Usage 280views 109downloads Citations Download citation Queenie Ayongo-Amoke Luortey, Kwame Osei Darkwah, Hope Agbodzakey, et al. Dyslipidemia in People Living with HIV/AIDS on Combination Antiretroviral Therapy: A Ghanaian Cross-sectional study.. Authorea. 09 January 2025. DOI: https://doi.org/10.22541/au.173641970.04080173/v1 DOI: https://doi.org/10.22541/au.173641970.04080173/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.