The Correlation Research of Bone Density on Women with Premature Ovarian Failure

Objective To evaluate the change of bone density and its associated factors in women with premature ovarian failure (POF).Methods 42 patients with POF undergoing bone mineral density (BMD) were selected,compared to 60 women paired by age whose menstrual cycles were regular.The associated factors with BMD of POF patients were analyzed.Results In women with POF,the mean bone mineral density was 0.92 g/cm2 at the lumbar spine and 0.87 g/cm2 at the neck of femur,both of which were significantly lower than the control group (P0.05).The BMD at lumbar spine and neck of femur of POF patients presented highly positive correlation with age and body mass index (BMI),and negative correlation with duration of estrogen deficiency and serum follicle-stimulating hormone (FSH) level.There was no significant correlation with age of menarche and serum luteinizing hormone (LH) level.Serum estradiol (E2) presented positive correlation with BMD of lumbar spine and no significant correlation with BMD of neck of femur.Conclusion Women with POF have a decrease in lumbar spine and femoral bone density.Age,BMI,duration of estrogen deficiency and FSH were associated with BMD.Early comprehensive therapy will be beneficial to prevent bone loss in POF patients.