Case Report:Sarcoidosis with Peripheral neuropathy

Case Report:Sarcoidosis with Peripheral neuropathy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Case Report:Sarcoidosis with Peripheral neuropathy Jing Li, Sha-Sha Yang, Min Xue, Mei Zhang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3543181/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Peripheral neuropathy is a broad term that encompasses various disorders of the peripheral nervous system. This includes granulomatous neuropathy and non- granulomatous small fiber neuropathy (SFN). The most prevalent clinical manifestations of granulomatous neuropathy are distal symmetric polyneuropathy and asymmetric polyradiculoneuropathy. Common causes of peripheral neuropathy include glycometabolic disturbance, infection, inflammation, and intoxication. However, cases of sarcoidosis are rare. Case Presentation: A 58-year-old female driving instructor with no previous medical history presented to the hospital with initial numbness in her left foot, followed by numbness and weakness in her right foot and both feet. A month later, she experienced bilateral numbness below the wrist. The patient underwent a lumbar puncture and further testing for auto-antibodies in both the cerebrospinal fluid (CSF) and serum. The results showed negative findings for seventeen antibodies related to peripheral neuropathy and Anti-MAG antibody. Enhanced chest CT revealed multiple swollen lymph nodes in the neck, mediastinum, and bilateral hilar area. Ultrasonography also confirmed enlarged lymph nodes in the bilateral supraclavicular, subclavian region, and mediastinum. Electromyography (EMG) and Nerve conduction studies (NCS) indicated asymmetric motor and sensory polyneuropathy. Additionally, the histological examination of a supraclavicular lymph node revealed characteristic non-caseating granulomas (NCG). Conclusion: This case report highlights the potential of peripheral neuropathy as a clinical manifestation of sarcoidosis. It emphasizes the importance of considering sarcoidosis as a possible diagnosis in patients presenting with peripheral neuropathy, thereby contributing to increased knowledge and reducing the risk of misdiagnosis. sarcoidosis peripheral neuropathy biopsy clinical manifestations Treatment Corticosteroids Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3543181","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":249313692,"identity":"dc46431a-2993-411b-a784-d497646cf4a0","order_by":0,"name":"Jing Li","email":"","orcid":"","institution":"First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan)","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jing","middleName":"","lastName":"Li","suffix":""},{"id":249313693,"identity":"78ff2914-e8fa-4ebb-90db-36c05894298b","order_by":1,"name":"Sha-Sha Yang","email":"","orcid":"","institution":"First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan)","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sha-Sha","middleName":"","lastName":"Yang","suffix":""},{"id":249313694,"identity":"2465f3ac-6657-4365-a644-90226d6f9a1c","order_by":2,"name":"Min Xue","email":"","orcid":"","institution":"First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan)","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Min","middleName":"","lastName":"Xue","suffix":""},{"id":249313695,"identity":"fac18818-2068-4de5-9ac0-bf120b1dd596","order_by":3,"name":"Mei Zhang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+UlEQVRIiWNgGAWjYBACAwYGNgiLmfnAgYQKGx5+/gaitbAlPvhwJk1GcsYBYrUw8Bgbzmw7bGPQkIBfi7l0+7MHP3fURvOzM5hJ85w5z2PAcIDxw8cc3Fos5xxIN+w9czx3ZjNDmjRPxW0ec+YGZsmZ2/A47EbCMQnetmO5Gw4zHAPacpvHsuEAGzMvXi2JbZJ/gVr2H2Zsk+ZtO8djcCCBkJZkNqDKmtwNzMzMQO8fIEZLGpu0bNuB3BmH2RiBgZzMIznjYDMBv6Q/k3zbVpfb33/+AzAq7ez5+ZsPfviIRwsUHEbmMDYQVA8EdcQoGgWjYBSMgpEKAJj3WE91ebOfAAAAAElFTkSuQmCC","orcid":"","institution":"First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan)","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Mei","middleName":"","lastName":"Zhang","suffix":""}],"badges":[],"createdAt":"2023-11-02 10:44:31","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3543181/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3543181/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":46566025,"identity":"a07d36f3-1652-47a8-999f-4a3989f301e4","added_by":"auto","created_at":"2023-11-16 15:11:30","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":800933,"visible":true,"origin":"","legend":"","description":"","filename":"CaseReportSarcoidosiswithPeripheralneuropathy.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3543181/v1_covered_3c97289f-fefe-41e7-8979-265d5486f0b9.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Case Report:Sarcoidosis with Peripheral neuropathy","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"sarcoidosis, peripheral neuropathy, biopsy, clinical manifestations, Treatment, Corticosteroids","lastPublishedDoi":"10.21203/rs.3.rs-3543181/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3543181/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003ePeripheral neuropathy is a broad term that encompasses various disorders of the peripheral nervous system. This includes granulomatous neuropathy and non- granulomatous small fiber neuropathy (SFN). The most prevalent clinical manifestations of granulomatous neuropathy are distal symmetric polyneuropathy and asymmetric polyradiculoneuropathy. Common causes of peripheral neuropathy include glycometabolic disturbance, infection, inflammation, and intoxication. However, cases of sarcoidosis are rare.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCase Presentation: \u003c/strong\u003eA 58-year-old female driving instructor with no previous medical history presented to the hospital with initial numbness in her left foot, followed by numbness and weakness in her right foot and both feet. A month later, she experienced bilateral numbness below the wrist. The patient underwent a lumbar puncture and further testing for auto-antibodies in both the cerebrospinal fluid (CSF) and serum. The results showed negative findings for seventeen antibodies related to peripheral neuropathy and Anti-MAG antibody. Enhanced chest CT revealed multiple swollen lymph nodes in the neck, mediastinum, and bilateral hilar area. Ultrasonography also confirmed enlarged lymph nodes in the bilateral supraclavicular, subclavian region, and mediastinum. Electromyography (EMG) and Nerve conduction studies (NCS) indicated asymmetric motor and sensory polyneuropathy. Additionally, the histological examination of a supraclavicular lymph node revealed characteristic non-caseating granulomas (NCG).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003eThis case report highlights the potential of peripheral neuropathy as a clinical manifestation of sarcoidosis. It emphasizes the importance of considering sarcoidosis as a possible diagnosis in patients presenting with peripheral neuropathy, thereby contributing to increased knowledge and reducing the risk of misdiagnosis.\u003c/p\u003e","manuscriptTitle":"Case Report:Sarcoidosis with Peripheral neuropathy","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2023-11-16 14:47:19","doi":"10.21203/rs.3.rs-3543181/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"6cae3198-4b51-4b67-affc-98cf9d26d1cc","owner":[],"postedDate":"November 16th, 2023","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-11-16T14:47:21+00:00","versionOfRecord":[],"versionCreatedAt":"2023-11-16 14:47:19","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3543181","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3543181","identity":"rs-3543181","version":["v1"]},"buildId":"cBFmMYwuxLRRLfASyISRj","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}