Effective Factors on Sharp Score in Patients with Rheumatoid Arthritis: A Retrospective Study

Abstract Background: This study aims to describe the association between Sharp Score and clincial indexes, bone metabolism indexes, Disease Activity Score (DAS28) and sociodemographic factors in rheumatoid arthritis (RA).Methods: Data were were collected from the HIS (hospital information system), a national inpatient database in China, with information on the patients hospitalized during the period from 2012 to 2019. The association between Sharp Score and effective factors were identified using multinomial logistic regression and association rule mining (ARM).Results: Three thousand eight hundred and forty patients were included: 82.66% males, 17.34% females, mean (SD) age 56.95 (12.68) years and symptom duration 3.45 (1.09) years. Spearman correlation analysis and Association rules analysis showed that there were significant positive correlations between Sharp Score and effective factors. Logistic regression analysis presented that erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (CRP), rheumatoid factor (RF) were risk factors of Sharp Score. In the analysis of individual outcomes, sex, age, symptom duration, DSA28 score, RF, ever drinker, radiographic grading of hands were influencents of Sharp Score.Conclusion: Sharp Score should be taken into consideration in formulating treatment strategies in RA.