Research Clinical Analysis and Risk Factors Associated With a Poor Prognosis in Nontuberculous Mycobacterial Infection: An 8-year Retrospective Cohort Study

Research Clinical Analysis and Risk Factors Associated With a Poor Prognosis in Nontuberculous Mycobacterial Infection: An 8-year Retrospective Cohort Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Research Clinical Analysis and Risk Factors Associated With a Poor Prognosis in Nontuberculous Mycobacterial Infection: An 8-year Retrospective Cohort Study Jing-Jing Chai, Su-Jie Zhang, Chong Ma, Qi-Min Mei, Tao Liu, Ji-Hai Liu, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4276329/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: In recent years, the incidence of Nontuberculous mycobacteria (NTM) disease has been increasing worldwide. This study aimed to identify risk factors affecting the prognosis and mortality of non-HIV NTM patients. Methods: This retrospective study was conducted at Peking Union Medical College Hospital. The electronic medical records in the hospital’s database from January 2013 to December 2022 were retrospectively reviewed. Relevant data, including clinical characteristics, laboratory findings, detected microorganisms, treatments, and outcomes were collected and subjected to statistical analyses. Results: The search identified 745 patients diagnosed with NTM infection, of whom 147 met the inclusion criteria. Pulmonary NTM was most commonly observed ( n =93; 63.3%), followed by disseminated infection ( n =43; 29.3%). The most frequent NTM species was Mycobacterium avium complex (55.8%), followed by Mycobacterium abscessus (21.2%). The incidence of Aspergillus and Pseudomonas aeruginosa infection was significantly higher in the pulmonary NTM group than in the disseminated NTM group. Cumulative mortality in the total patients was 24.49% at 5 years. High charlson comorbidity index (CCI), high neutrophil-to-lymphocyte-ratio (NLR), hematological disease, and disseminated infection were identified as independent predictors of unfavorable outcomes. The area under the curve (AUC) values for NLR and NMLR were 0.751 and 0.763 with optimal cut-off values of 9.50 and 3.83, respectively, for prediction of mortality in NTM patients. Conclusions: High CCI, high NLR, hematological disease, and disseminated infection were identified as independent predictors of mortality in non-HIV NTM patients. Nontuberculous mycobacteria mortality comorbidity disseminated prognosis Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4276329","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":293711611,"identity":"3eb62000-ec22-45aa-8db5-57bb6e7be44a","order_by":0,"name":"Jing-Jing Chai","email":"","orcid":"","institution":"Chinese Academy of Medical Sciences and Peking Union Medical College","correspondingAuthor":false,"prefix":"","firstName":"Jing-Jing","middleName":"","lastName":"Chai","suffix":""},{"id":293711612,"identity":"8af7bf34-795e-4f55-898a-55d6ba25f881","order_by":1,"name":"Su-Jie Zhang","email":"","orcid":"","institution":"The First Affiliated 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This study aimed to identify risk factors affecting the prognosis and mortality of non-HIV NTM patients.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e\u003c/em\u003e\u003cstrong\u003e \u003c/strong\u003eThis retrospective study was conducted at Peking Union Medical College Hospital. The electronic medical records in the hospital’s database from January 2013 to December 2022 were retrospectively reviewed. Relevant data, including clinical characteristics, laboratory findings, detected microorganisms, treatments, and outcomes were collected and subjected to statistical analyses.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eResults:\u003c/strong\u003e\u003c/em\u003e\u003cstrong\u003e \u003c/strong\u003eThe search identified 745 patients diagnosed with NTM infection, of whom 147 met the inclusion criteria. Pulmonary NTM was most commonly observed (\u003cem\u003en\u003c/em\u003e=93; 63.3%), followed by disseminated infection (\u003cem\u003en\u003c/em\u003e=43; 29.3%). The most frequent NTM species was \u003cem\u003eMycobacterium avium \u003c/em\u003ecomplex (55.8%), followed by \u003cem\u003eMycobacterium abscessus\u003c/em\u003e (21.2%). The incidence of \u003cem\u003eAspergillus\u003c/em\u003e and \u003cem\u003ePseudomonas aeruginosa\u003c/em\u003e infection was significantly higher in the pulmonary NTM group than in the disseminated NTM group. Cumulative mortality in the total patients was 24.49% at 5 years. High charlson comorbidity index (CCI), high neutrophil-to-lymphocyte-ratio (NLR), hematological disease, and disseminated infection were identified as independent predictors of unfavorable outcomes. 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