Extrauterine Mesonephric-like Neoplasms: Expanding the Morphologic Spectrum

Extrauterine mesonephric-like neoplasms : expanding the morphologic spectrum - Author - Ellen Deolet, Iteeka Arora, Jo Van Dorpe (UGent) , Joni Van der Meulen (UGent) , Sudha Desai, Nadine Van Roy (UGent) , Baljeet Kaur, Koen Van de Vijver (UGent) and W Glenn McCluggage - Organization - Abstract - Mesonephric-like adenocarcinomas (MLA) are rare neoplasms arising in the uterine corpus and ovary which have been added to the recent 2020 World Health Organization Classification of Female Genital Tumors. They have similar morphology and immunophenotype and exhibit molecular aberrations similar to cervical mesonephric adenocarcinomas. It is debated as to whether they are of mesonephric or Mullerian origin. We describe the clinical, pathologic, immunohistochemical, and molecular features of 5 cases of extrauterine mesonephric-like proliferations (4 ovary, 1 extraovarian), all with novel and hitherto unreported features. These include an origin of MLA in extraovarian endometriosis, an association of ovarian MLA with high-grade serous carcinoma, mixed germ cell tumor and mature teratoma, and a borderline ovarian endometrioid tumor exhibiting mesonephric differentiation. Four of the cases exhibited a KRAS variant and 3 also a PIK3CA variant. In reporting these cases, we expand on the published tumor types associated with MLA and report for the first time a borderline tumor exhibiting mesonephric differentiation. We show the value of molecular testing in helping to confirm a mesonephric-like lesion and in determining the relationship between the different neoplastic components. We provide further evidence for a Mullerian origin, rather than a true mesonephric origin, in some of these cases. We also speculate that in the 2 cases associated with germ cell neoplasms, the MLA arose out of the germ cell tumor. - Keywords - Ovary, mesonephric-like adenocarcinoma, extrauterine, immunohistochemistry, molecular, YOLK-SAC TUMOR, RECURRENT KRAS MUTATIONS, FEMALE GENITAL-TRACT, UTERINE CERVIX, CELL TUMOR, ADENOCARCINOMAS, CARCINOMA, BENIGN, OVERREPRESENTATION, TRISOMY-12 Downloads - (...).pdf - full text (Published version) - | - UGent only - | - | - 574.82 KB Citation Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8714330 - MLA - Deolet, Ellen, et al. “Extrauterine Mesonephric-like Neoplasms : Expanding the Morphologic Spectrum.” AMERICAN JOURNAL OF SURGICAL PATHOLOGY, vol. 46, no. 1, 2022, pp. 124–33, doi:10.1097/PAS.0000000000001766. - APA - Deolet, E., Arora, I., Van Dorpe, J., Van der Meulen, J., Desai, S., Van Roy, N., … McCluggage, W. G. (2022). Extrauterine mesonephric-like neoplasms : expanding the morphologic spectrum. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 46(1), 124–133. https://doi.org/10.1097/PAS.0000000000001766 - Chicago author-date - Deolet, Ellen, Iteeka Arora, Jo Van Dorpe, Joni Van der Meulen, Sudha Desai, Nadine Van Roy, Baljeet Kaur, Koen Van de Vijver, and W Glenn McCluggage. 2022. “Extrauterine Mesonephric-like Neoplasms : Expanding the Morphologic Spectrum.” AMERICAN JOURNAL OF SURGICAL PATHOLOGY 46 (1): 124–33. https://doi.org/10.1097/PAS.0000000000001766. - Chicago author-date (all authors) - Deolet, Ellen, Iteeka Arora, Jo Van Dorpe, Joni Van der Meulen, Sudha Desai, Nadine Van Roy, Baljeet Kaur, Koen Van de Vijver, and W Glenn McCluggage. 2022. “Extrauterine Mesonephric-like Neoplasms : Expanding the Morphologic Spectrum.” AMERICAN JOURNAL OF SURGICAL PATHOLOGY 46 (1): 124–133. doi:10.1097/PAS.0000000000001766. - Vancouver - 1.Deolet E, Arora I, Van Dorpe J, Van der Meulen J, Desai S, Van Roy N, et al. Extrauterine mesonephric-like neoplasms : expanding the morphologic spectrum. AMERICAN JOURNAL OF SURGICAL PATHOLOGY. 2022;46(1):124–33. - IEEE - [1]E. Deolet et al., “Extrauterine mesonephric-like neoplasms : expanding the morphologic spectrum,” AMERICAN JOURNAL OF SURGICAL PATHOLOGY, vol. 46, no. 1, pp. 124–133, 2022. @article{8714330, abstract = {{Mesonephric-like adenocarcinomas (MLA) are rare neoplasms arising in the uterine corpus and ovary which have been added to the recent 2020 World Health Organization Classification of Female Genital Tumors. They have similar morphology and immunophenotype and exhibit molecular aberrations similar to cervical mesonephric adenocarcinomas. It is debated as to whether they are of mesonephric or Mullerian origin. We describe the clinical, pathologic, immunohistochemical, and molecular features of 5 cases of extrauterine mesonephric-like proliferations (4 ovary, 1 extraovarian), all with novel and hitherto unreported features. These include an origin of MLA in extraovarian endometriosis, an association of ovarian MLA with high-grade serous carcinoma, mixed germ cell tumor and mature teratoma, and a borderline ovarian endometrioid tumor exhibiting mesonephric differentiation. Four of the cases exhibited a KRAS variant and 3 also a PIK3CA variant. In reporting these cases, we expand on the published tumor types associated with MLA and report for the first time a borderline tumor exhibiting mesonephric differentiation. We show the value of molecular testing in helping to confirm a mesonephric-like lesion and in determining the relationship between the different neoplastic components. We provide further evidence for a Mullerian origin, rather than a true mesonephric origin, in some of these cases. We also speculate that in the 2 cases associated with germ cell neoplasms, the MLA arose out of the germ cell tumor.}}, author = {{Deolet, Ellen and Arora, Iteeka and Van Dorpe, Jo and Van der Meulen, Joni and Desai, Sudha and Van Roy, Nadine and Kaur, Baljeet and Van de Vijver, Koen and McCluggage, W Glenn}}, issn = {{0147-5185}}, journal = {{AMERICAN JOURNAL OF SURGICAL PATHOLOGY}}, keywords = {{Ovary,mesonephric-like adenocarcinoma,extrauterine,immunohistochemistry,molecular,YOLK-SAC TUMOR,RECURRENT KRAS MUTATIONS,FEMALE GENITAL-TRACT,UTERINE CERVIX,CELL TUMOR,ADENOCARCINOMAS,CARCINOMA,BENIGN,OVERREPRESENTATION,TRISOMY-12}}, language = {{eng}}, number = {{1}}, pages = {{124--133}}, title = {{Extrauterine mesonephric-like neoplasms : expanding the morphologic spectrum}}, url = {{http://doi.org/10.1097/PAS.0000000000001766}}, volume = {{46}}, year = {{2022}}, } - Altmetric - View in Altmetric - Web of Science - Times cited: