Regioselective synthesis of 4-fluoro-1,5-substituted-1,2,3-triazoles from synthetic surrogates of 1-fluoroalkynes

2019 · doi:10.26434/chemrxiv.9738656.v3
preprint OA: closed CC-BY-NC-ND-4.0
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Abstract

Here, we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount of trifloroacetic acid. This work provides the first regioselective method to access 4-fluoro-1,5-substituted-1,2,3-triazoles.

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europepmc
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License: CC-BY-NC-ND-4.0