GBR using PTFEE membranes

GBR using PTFEE membranes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report GBR using PTFEE membranes Sinan Arllati, Kreshnik Syka This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5737446/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Guided Bone Regeneration (GBR) is a well-established technique used to augment bone volume in edentulous areas, thereby facilitating successful dental implant placement. One critical component of GBR is the use of barrier membranes that prevent soft tissue invasion into the defect site, thus creating a space that allows for bone regeneration. In this case report, we explore the use of Porcine Trabecular Free-Edge (PTFEE) membranes in GBR to treat a bone-deficient edentulous site in the posterior maxilla. The combination of PTFEE membranes and a mixture of autogenous bone, allograft, and xenograft materials provided favorable outcomes, enabling successful implant placement. Case report Patient Information: A 39 year old female patient presented with significant bone loss in the upper left posterior maxilla, limiting the possibility of implant placement. Patient male presented with significant bone loss in the upper left posterior maxilla, limiting implant placement. Treatment Protocol: The treatment plan involved performing GBR to regenerate the bone using PTFEE membranes, autogenous bone, allograft, and xenograft materials. GBR was performed using PTFEE membranes along with a mixture of autogenous bone, allograft, and xenograft. (Photo 1,2) The PTFEE membrane was placed to exclude soft tissue and support bone regeneration. After 4 months (Photo 3.), radiographic evaluation showed substantial bone regeneration, allowing for successful implant placement (Photo 4). The patient was prescribed antibiotics and pain medication post-surgery. Follow-up appointments were scheduled to monitor healing.appointments were scheduled to monitor healing. Results After a healing period of 4 months, radiographic evaluation demonstrated significant bone regeneration, allowing for the placement of a dental implant. The implant was inserted with good primary stability. Initial healing after implant placement was uneventful, with no signs of infection or complications. Radiographs showed excellent osseointegration, and the implant served as a stable foundation for the final prosthesis. The combination of autogenous bone, allograft, and xenograft materials used in this case is known to enhance bone healing. Autogenous bone grafts are particularly effective because they contain live osteogenic cells that promote bone formation. Allografts and xenografts provide structural scaffolds that support the growth and remodeling of the bone tissue. This mixed grafting approach is widely accepted as a reliable method for improving the volume and quality of bone in GBR procedures (Hämmerle & Jung, 2003; Buser et al., 2002). Several studies have demonstrated the efficacy of GBR using PTFEE membranes in various clinical scenarios. For instance, research has shown that PTFEE membranes effectively support bone regeneration in both the maxilla and mandible, promoting adequate bone volume for implant placement (Schlee & Steigmann, 2010). Moreover, the combination of different graft materials enhances the biological and mechanical properties of the newly formed bone, contributing to better outcomes in dental implant placement (Cortellini & Tonetti, 2007). Conclusion The use of Porcine Trabecular Free-Edge (PTFEE) membranes in combination with autogenous bone, allograft, and xenograft materials successfully facilitated bone regeneration in a posterior maxillary site, enabling the placement of a dental implant. The procedure was uncomplicated, with no signs of infection or complications, and the implant exhibited good osseointegration. This case demonstrates that PTFEE membranes are an effective and reliable option for bone regeneration in GBR procedures, offering a solution for bone-deficient sites that require augmentation for implant placement. Declarations Consent to published was obtained References Hämmerle, C. H. F., & Jung, R. E. (2003). Bone augmentation by guided bone regeneration: A systematic review. Clinical Oral Implants Research, 14 (3), 50-66. Buser, D., Dula, K., & Hirt, H. P. (2002). The use of membranes in guided bone regeneration procedures for dental implants. European Journal of Oral Sciences, 110 (6), 522-529. Schlee, M., & Steigmann, M. (2010). Bone augmentation using a combination of autogenous bone, allograft, and xenograft materials. International Journal of Oral and Maxillofacial Implants, 25 (5), 989-993. Cortellini, P., & Tonetti, M. S. (2007). Guided bone regeneration in implant dentistry. Periodontology 2000, 43 (1), 31-52. Photos Photos 1-4 are available in the Supplementary Files section. Additional Declarations No competing interests reported. Supplementary Files Photos.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5737446","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":396212519,"identity":"41ed30f5-64c9-4d02-9ab8-028acca235b1","order_by":0,"name":"Sinan Arllati","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7UlEQVRIiWNgGAWjYDACZgglwwckDnwAEmzsRGrhYQOyDs4AaWEm0jKwFmYeJENwAvl23oOfC2ru8bCxnz942ObXNnk+ZgbGDx9zcGsxOMyXLD3jWDEPG08yw+HcvtuGbUDbJGduw6OFmcdAmoctAegwkJae24xALWzMvHi0yDfzGP/m+QfUwv+Y4bBlz217gloYDvOYSfO2AbVIAG1h+HE7kaAWA6AWa94+kJbHBgd7G24ntzEzNuP1i3z/GePbPN8S5Pj5Ex9/+PHntu389uaDHz7icxgKYGwDkw3EqgeBP6QoHgWjYBSMgpECAFFnRUERMN4WAAAAAElFTkSuQmCC","orcid":"","institution":"","correspondingAuthor":true,"prefix":"","firstName":"Sinan","middleName":"","lastName":"Arllati","suffix":""},{"id":396212520,"identity":"0af65484-338b-4636-922a-3866e2340291","order_by":1,"name":"Kreshnik Syka","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Kreshnik","middleName":"","lastName":"Syka","suffix":""}],"badges":[],"createdAt":"2024-12-30 18:38:05","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5737446/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5737446/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":78013061,"identity":"8f4da1cc-1f91-4c1c-800d-387d0b2f82ff","added_by":"auto","created_at":"2025-03-07 21:53:35","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":194293,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5737446/v1/268605f6-1f59-4057-b327-eb95ec631595.pdf"},{"id":72729056,"identity":"b1b79dc3-42f3-4791-87bb-41c7a4cdc540","added_by":"auto","created_at":"2025-01-01 05:27:33","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":460272,"visible":true,"origin":"","legend":"","description":"","filename":"Photos.docx","url":"https://assets-eu.researchsquare.com/files/rs-5737446/v1/08f570a1eadb2386555a0dd2.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"GBR using PTFEE membranes","fulltext":[{"header":"Case report ","content":"\u003cp\u003e\u003cstrong\u003ePatient Information:\u003c/strong\u003e\u003cbr\u003e A 39 year old female patient presented with significant bone loss in the upper left posterior maxilla, limiting the possibility of implant placement. Patient male presented with significant bone loss in the upper left posterior maxilla, limiting implant placement. \u003cbr\u003e \u003cbr\u003e\u003cstrong\u003eTreatment Protocol:\u003c/strong\u003e\u003cbr\u003e \u003cbr\u003e The treatment plan involved performing GBR to regenerate the bone using PTFEE membranes, autogenous bone, allograft, and xenograft materials.\u003cbr\u003eGBR was performed using PTFEE membranes along with a mixture of autogenous bone, allograft, and xenograft. \u003cstrong\u003e(Photo 1,2)\u003c/strong\u003e\u003cbr\u003e The PTFEE membrane was placed to exclude soft tissue and support bone regeneration.\u003cbr\u003eAfter 4 months \u003cstrong\u003e(Photo 3.),\u003c/strong\u003e radiographic evaluation showed substantial bone regeneration, allowing for successful implant placement\u003cstrong\u003e(Photo 4).\u003c/strong\u003e\u003cbr\u003e The patient was prescribed antibiotics and pain medication post-surgery. Follow-up appointments were scheduled to monitor healing.appointments were scheduled to monitor healing.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eAfter a healing period of 4 months, radiographic evaluation demonstrated significant bone regeneration, allowing for the placement of a dental implant. The implant was inserted with good primary stability. Initial healing after implant placement was uneventful, with no signs of infection or complications. Radiographs showed excellent osseointegration, and the implant served as a stable foundation for the final prosthesis.\u003c/p\u003e \u003cp\u003eThe combination of autogenous bone, allograft, and xenograft materials used in this case is known to enhance bone healing. Autogenous bone grafts are particularly effective because they contain live osteogenic cells that promote bone formation. Allografts and xenografts provide structural scaffolds that support the growth and remodeling of the bone tissue. This mixed grafting approach is widely\u003c/p\u003e \u003cp\u003eaccepted as a reliable method for improving the volume and quality of bone in GBR procedures (H\u0026auml;mmerle \u0026amp; Jung, 2003; Buser et al., 2002).\u003c/p\u003e \u003cp\u003eSeveral studies have demonstrated the efficacy of GBR using PTFEE membranes in various clinical scenarios. For instance, research has shown that PTFEE membranes effectively support bone regeneration in both the maxilla and mandible, promoting adequate bone volume for implant placement (Schlee \u0026amp; Steigmann, 2010). Moreover, the combination of different graft materials enhances the biological and mechanical properties of the newly formed bone, contributing to better outcomes in dental implant placement (Cortellini \u0026amp; Tonetti, 2007).\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThe use of Porcine Trabecular Free-Edge (PTFEE) membranes in combination with autogenous bone, allograft, and xenograft materials successfully facilitated bone regeneration in a posterior maxillary site, enabling the placement of a dental implant. The procedure was uncomplicated, with no signs of infection or complications, and the implant exhibited good osseointegration. This case demonstrates that PTFEE membranes are an effective and reliable option for bone regeneration in GBR procedures, offering a solution for bone-deficient sites that require augmentation for implant placement.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eConsent to published was obtained\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n \u003cli\u003eHämmerle, C. H. F., \u0026amp; Jung, R. E. (2003). Bone augmentation by guided bone regeneration: A systematic review. \u003cem\u003eClinical Oral Implants Research, 14\u003c/em\u003e(3), 50-66.\u003c/li\u003e\n \u003cli\u003eBuser, D., Dula, K., \u0026amp; Hirt, H. P. (2002). The use of membranes in guided bone regeneration procedures for dental implants. \u003cem\u003eEuropean Journal of Oral Sciences, 110\u003c/em\u003e(6), 522-529.\u003c/li\u003e\n \u003cli\u003eSchlee, M., \u0026amp; Steigmann, M. (2010). Bone augmentation using a combination of autogenous bone, allograft, and xenograft materials. \u003cem\u003eInternational Journal of Oral and Maxillofacial Implants, 25\u003c/em\u003e(5), 989-993.\u003c/li\u003e\n \u003cli\u003eCortellini, P., \u0026amp; Tonetti, M. S. (2007). Guided bone regeneration in implant dentistry. \u003cem\u003ePeriodontology 2000, 43\u003c/em\u003e(1), 31-52.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Photos","content":"\u003cp\u003ePhotos 1-4 are available in the Supplementary Files section.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-5737446/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5737446/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eGuided Bone Regeneration (GBR) is a well-established technique used to augment bone volume in edentulous areas, thereby facilitating successful dental implant placement. One critical component of GBR is the use of barrier membranes that prevent soft tissue invasion into the defect site, thus creating a space that allows for bone regeneration. In this case report, we explore the use of Porcine Trabecular Free-Edge (PTFEE) membranes in GBR to treat a bone-deficient edentulous site in the posterior maxilla. The combination of PTFEE membranes and a mixture of autogenous bone, allograft, and xenograft materials provided favorable outcomes, enabling successful implant placement.\u003c/p\u003e","manuscriptTitle":"GBR using PTFEE membranes","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-01-01 05:27:29","doi":"10.21203/rs.3.rs-5737446/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"dea80f6c-5446-4613-90dc-36d82a38fce7","owner":[],"postedDate":"January 1st, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-03-07T21:53:10+00:00","versionOfRecord":[],"versionCreatedAt":"2025-01-01 05:27:29","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5737446","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5737446","identity":"rs-5737446","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}