Comparative Study of Serum Soluble Intercellular Adhesion Molecule-1 in Different Obese Women with Polycystic Ovary Syndrome

Objective:To study the level of serum soluble intercellular adhesion molecule-1(sICAM-1) in obese women with polycystic ovary syndrome (PCOS). Methods: The obese patients with PCOS were divided into two groups (obese A group and non-obese A group) according to the standard of body mass index (BMI) ≥ 24 kg/m2. The patients were divided into two groups (obese B group and non-obese B group) according to the standard of waist-hip ratio (WHR) ≥ 0.8. The patients were also divided into two groups(obese C groups and non-obese C group) according to the standard of BMI≥ 24 kg/m2 and WHR≥ 0.8. The serum levels of sICAM-1 were compared between groups. The correlation was analysed between the level of sICAM-1 and the values of BMI and WHR. Results:The serum levels of sICAM-1 were significantly higher in obese A, obese B and obese C groups than those of non-obese A, non-obese B and non-obese C groups (P 0.05). There were no significant differences in serum levels of sICAM-1 between obese A, obese B and obese C groups (P 0.05).The serum level of sICAM-1 was significant higher in non-obese A group than that of non-obese B group and non-obese C group (P 0.05).But there was no significant difference in serum level of sICAM-1 between the patients of non-obese B group and non-obese C group (P 0.05).There was a positive correlation between the serum level of sICAM-1,BMI and WHR(P 0.05). Conclusion:There was a close correlation between the serum level of sICAM-1 and the obesity in patients with PCOS. The level of sICAM-1 increased with the increase in WHR and BMI in patients with PCOS.