Роль Pla полиморфизма гена GPIIIa в развитии миомы матки, аденомиоза и их сочетания

Objective: to evaluate the allele distribution of GPIIIA gene among patients with leiomyoma (I group), adenomyosis (II group), and their combination (III group). Methods: PCR analysis. Results: a great majority of the patients with leiomyoma, adenomyosis and their combination were found to be homozygous for PLAl allele. PLA2 allele of the gene was revealed only for two heterozygous patients of III group. Conclusion: leiomyoma, adenomyosis and their combination are associated with genotype A1A1 of GPIIIA gene. PLA2 allele of the gene reduces the risk of these diseases of about 10 times.