The physicochemical and phylogenetic properties of twelve spike glycoprotein models for SARS-CoV-2 from China, Iran, and Tunisia

The physicochemical and phylogenetic properties of twelve spike glycoprotein models for SARS-CoV-2 from China, Iran, and Tunisia | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research The physicochemical and phylogenetic properties of twelve spike glycoprotein models for SARS-CoV-2 from China, Iran, and Tunisia Samih A. Odhaib, Hayder Al-Aubaidy This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-63469/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background The coronavirus spike glycoprotein is a trimeric structural surface protein that facilitates the viral adhesion through attaching receptors on the human cell surface. This study aims to analyse and compare the genomic and phylogenetic properties of these spike glycoproteins from China, Iran, and Tunisia. Methods This is a descriptive cross-sectional comparative study for the different properties of S glycoprotein from 12 SARS-CoV-2 specimens from GenBank. Clustal Omega was used to study model sequences alignment, residual conservation, phylogeny, and identity matrix. SWISS-MODEL developed and validated the 3D models for three protein sequences with the highest model quality. The different physicochemical characteristics of different models were assessed by ExPASy proteomics. Results The Chinese and the Iranian sequences share 100% identity, although they have a different amino acids number, and 25-29.27% identity to the Tunisian sequences. The 12 models are monophyletic, with varying stages of evolutionary divergence. There are six fully, three highly, and five lowly conserved residues across the sequences. The resulting three highly reliable 3D models were of different global qualities, being the lowest for the Tunisian, and the highest for the Iranian models. All the models are highly hydrophilic. The Tunisian models were unstable in comparison to the relatively stable other models with different physicochemical characteristics. Conclusion The models had different N-terminal residues and side groups polarity and charge. The S glycoproteins are not identical nor unique in model structure nor the physicochemical profiles in different parts of the world. The Tunisian models are drastically biodiverse from the Chinese and Iranian models. Virology Coronavirus phylogeny protein sequences SWISS-MODEL Figures Figure 1 Figure 2 Highlights The coronavirus spike glycoprotein facilitates the viral adhesion to the susceptible human cells and may contribute to its virulence. The spike glycoprotein is the main inducer of neutralizing antibodies. What’s New: Although the different COVID-19 spike glycoproteins from different countries are monophyletic, they are not identical nor unique in model structure nor the physicochemical properties. The stable Chinese and Iranian sequence models of the glycoprotein shared 100% identity, while they shared 25-29.27% to unstable Tunisian models. Background SARS coronavirus (SARS-CoV-2) is a spherical pleomorphic enveloped particle, containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. The envelope bears spike (S) glycoprotein [ 1 ]. This S-glycoprotein is trimeric and consists of three S1-S2 heterodimers that determine the adhesion and viral virulence through its ability to attach different receptors with a distinctive affinity to the angiotensin-converting enzyme 2 (ACE-2) receptors on the human cell surface [ 2, 3]. During viral infection, the S glycoprotein is cleaved into S1 and S2 subunits at a furin-like cleavage site through a cascade of proteolytic enzymes [ 4 ]. S1 subunit determines the virus-host range and cellular tropism through the receptor-binding domain (RBD) and N-terminal domain to bind directly to the ACE-2 receptor [ 3 , 5 , 6 ], which serve as a functional receptor for this virus [ 7 ]. S2 subunit acts as a class I viral fusion protein and mediates virus-cell membrane fusion by two heptad repeats [ 8 ]. The viral adhesion to the host cell involves a complex pre- to post-fusion conformation transition [ 3 ], and it is ten times tighter than the corresponding S protein of other coronaviruses to their corresponding receptors [ 9 ]. The S glycoprotein is a surface protein and acts as the main inducer of neutralizing antibodies, T-cell response, and possible protective immunity, which make this protein a target for therapeutic intervention and vaccine development [ 10 ]. This study highlighted the genomic and phylogenetic properties of SARS-CoV-2 spike glycoprotein sequences from three countries China, Iran, and Tunisia. Materials And Methods This is a descriptive cross-sectional comparative study analyzing the genomic and phylogenetic properties of S glycoprotein from 12 SARS-CoV-2 specimens from China (seven isolates), Iran (two isolates), and Tunisia (three isolates). The genomic coding and amino acid sequences of the SARS-CoV-2 are available in the GenBank ( https://www.ncbi.nlm.nih.gov/genbank/sars-cov-2-seqs/ ) [ 11 ]. The identical proteins were identified by the (Identical Protein Group) to simplify the evaluation by choosing one descriptive representative sequence from each country. The (Multiple Sequence Alignment) at Clustal Omega ( https://www.ebi.ac.uk/Tools/msa/clustalo/ ) of the European Molecular Biology Laboratory- European Bioinformatics Institute (EMBL-EBI) [ 12 ] was used to study amino acid sequences alignment of the 12 sequences. Clustal Omega tools can determine any conserved residues in the 12 models. The Phylogenetic Tree and Percent Identity Matrix were used to study the nature and the percentage of the similarity between the 12 sequences. The phylogenetic tree (phylogeny) is a diagram that depicts the lines of evolutionary descent in the protein sequences. A phylogenetic tree portrays the branching history of common ancestry, and the pattern of branching using cladograms and phylogram. The branching pattern reflects different evolutionary lineages [ 13 , 14 ]. We chose three amino acid sequences with the highest protein identities (QHN73805.1, QIQ08768.1, and QIV64962.1) from (China, Iran, and Tunisia) respectively, for developing and validating 3D sequence models using the SWISS-MODEL ( https://swissmodel.expasy.org/interactive#structure ) , along with the structural assessment tools to confirm the structured model [ 15 – 17 ]. The Tunisian protein sequences (QIZ14987.1 and QIZ14988.1) of Tunisia are identical. Still, we could not include any of their sequences because they contain unidentified amino acids at an abnormal position, which makes them unsuitable for modeling by the SWISS-MODEL [ 15 ]. The sequence modeling for the chosen proteins was evaluated according to their local and global quality estimates by the use of: Global Model Quality Estimation (GMQE) reflects modeling accuracy and reliability. The resulting score is expressed as a number between 0 and 1; the higher the number was, the more the reliability was [ 18 ]. Qualitative Model Energy Analysis (QMEAN): The composite estimator of the different geometrical properties of the protein sequence that provides both global (for the entire structure) and local (per residue) absolute quality estimates based on one single model [ 18 , 19 ]. The QMEAN Z-score estimates the "degree of nativeness" of the structural features observed in the model on a global scale. The QMEAN Z-score compares the model QMEAN score to the scores of the similar size expected experimental structures, through Cβ atoms only, all atoms, the solvation potential, and the torsion angle potential [ 18 , 19 ]. The QMEANDisCo enhances the accuracy of the QMEAN local scores by assessing the interatomic distance of the target model against the already ensemble information of the experimentally determined proteins that share homology to the target model [ 19 ]. ProtParam tool at the ExPASy proteomics server ( https://web.expasy.org/protparam/ ) was used to study and computes various physicochemical properties of a protein sequence [ 20 ]. It provides information about different indices and scores: Molecular weight. The number and charges of different amino acid residues. The chemical formula. Tryptophan residues availability. Site and type of N-terminal residues. Extinction coefficients indicate how much light a protein absorbs at a particular wavelength, which is useful during the purification process. Optical density (Absorbance) which is the product of dividing the extinction coefficient by the molecular weight [ 21 ]. In vivo half-life. Instability index (II) which provides an estimate of the stability of your protein in a test tube. The (II) of stable proteins is 40. The aliphatic index is the relative volume occupied by aliphatic side chains (alanine, valine, isoleucine, and leucine) [ 22 ]. Grand Average of Hydropathy (GRAVY) marks the protein as hydrophilic (negative values) or hydrophobic (positive values) [ 23 ]. The Protein Molecular Weight – The Sequence Manipulation Suite at Bioinformatics.org ( https://www.bioinformatics.org/sms/prot_mw.html ) was used to compare the actual molecular weight of different protein sequences, without including any unknown amino acids [ 24 ]. Results Table 1 demonstrates the GenBank accession numbers of AA sequences of the 12 S glycoproteins of the SARS-CoV-2 from China, Iran, and Tunisia (this represent the whole worldwide plotted sequences until April 20th, 2020). The Tunisian sequences had the most abundant amino acid number in comparison to the Iranian and Chinese sequences. The sequences (QIZ14987.1 and QIZ14988.1) are identical, and they contain an abnormal amino acid at an ambiguous position. The Identical Protein Group provides information about the identical protein sequences from each country. All the Chinese sequences are shown in Table 1, were isolated on the same day (February 11th, 2020) from the (Wuhan seafood market pneumonia virus), from the nasopharyngeal swab, serum, throat swab, and sputum. All other sequences from Iran and Tunisia were taken from the nasopharyngeal swabs. Figure 1 demonstrates the multiple sequence alignment of different sequences. There are six fully, three highly, and five lowly conserved residues. The Chinese and the Iranian sequences share 100% similarity, while the Tunisian sequences had 25 and 29.27% similarity to the Chinese and the Iranian sequences, respectively. The first Tunisian sequence described (QIV64962.1) had 99.39% similarity to the other two sequences (QIZ14987.1 and QIZ14988.1) because of the unidentified amino acid at the ambiguous position (Table 2, and Figure 1). The first divergence event separated the lineage that gave rise to the (China-Shenzhen 7) sequence from a lineage of the other six Chinese sequences and a lineage that gave rise to the Iranian and Tunisian sequences, i.e., the 12 sequences shared a common ancestry (monophyletic group). The (China-Shenzhen 1 and 2) share a more recent common ancestor than either share with other sequences, i.e., they are therefore more closely related to each other than either is to other sequences. The (Tunisia-Tunis 2 and 3) sequences underwent recent evolutionary divergence that occurred (Supplementary Figure 1 A and B). Because all the Chinese and Iranian sequences are of equal distance (in terms of branch arrangement) from their original ancestor, we could say that these sequences are equally related to each other. The three Tunisian sequences underwent the most recent divergence from the original evolutionary lineage. The 3D models of the S glycoproteins from the three chosen sequences from the three countries were highly reliable models with a very high GMQE score. Still, they demonstrated that the very low global quality, very low QMEAN-scored Tunisian S glycoprotein had three chains in comparison to the Chinese sequence of medium global quality and the Iranian sequences of the highest global quality between the three countries. The Z-scores of all three sequences fall within the range between (0.5-0.7) (Figure 2 and Supplementary Figure 2). The Tunisian sequences had the highest molecular weight, extinction index, and instability index (II) between the chosen sequences, which renders the Tunisian sequences unstable in comparison to both the Chinese and the Iranian sequences, which are relatively stable at different degrees. All the sequences are hydrophilic and share a high aliphatic index (Table 3). The N-terminals which signify the beginning of the S1 subunit of the S glycoprotein in SARS-CoV-2 are different in their chemical profiles: For the Chinese sequences, it is N (Asparagine), which is polar with a positively charged side group. For the Iranian sequences, it is P (Proline), which is nonpolar with an uncharged side group. For the Tunisian sequences, it is Q (Glutamine), which is polar with an uncharged side group. These biophysical changes affect the half-life of the protein models in vitro and in vivo (Table 3). Discussion The coronavirus S glycoprotein is an important structural protein that is responsible for the phenotype of crown-like shape viral particles, from which the original name “coronavirus” was coined [ 4 ]. The GenBank provides unrestricted access to all types of genomic and polypeptide sequences that dealt with the novel coronavirus epidemic by SARS-CoV-2 [ 11 ]. Till the preparation of this paper (April 20th, 2020), only the Chinese sequences of S glycoprotein of SARS-CoV-2 were assessed and compared through the literature [ 25 – 27 ]. The Iranian and the Tunisian sequences were not assessed after being uploaded in the GenBank. The three Tunisian models represent the largest S glycoprotein unit, in comparison to the Chinese and Iranian S glycoproteins, with their higher number of base pairs and a consequently higher number of amino acid residues. Even though the assessment of the Percent Identity Matrix by Clustal 2.1. revealed a 100% similarity or identity between the Chinese and the Iranian sequences, although the numbers of amino acid residues are different. Two out of the three Tunisian sequences (QIZ14987.1 and QIZ14988.1) were identical 100% but share a 25% identity with the Chinese and Iranian sequences. The presence of an unknown amino acid (X) at an ambiguous position in these sequences minimally decreased the identity of the sequences (QIZ14987.1 and QIZ14988.1) to the third Tunisian sequence (QIV64962.1) by 0.61% to be 99.39%. on the other hand, the Tunisian sequence (QIV64962.1) shared a 29.27% identity with the Chinese and Iranian sequences. Shanker and colleagues had studied the amino acid sequences of the seven S glycoprotein units from China and reached the same conclusion [ 27 ]. The N-terminal identifies the start of the S1 subunit in the three modeled sequences. There was a different polarity for the N-terminal residues, being polar with a positively charged side group in the Chinese model, nonpolar with uncharged side group in the Iranian model, and polar with uncharged side group in the Tunisian model [ 4 , 6 ]. The S glycoprotein remains uncleaved at the S1/S2 site during virus packaging in cells. The trimetric S-protein is processed at the S1/S2 furin-like cleavage site by host cell proteases, during infection [ 28 ]. We combined the SWISS-MODEL and the Clustal Omega modeling to find the possible furin-like S1/S2 cleavage site that was thoroughly described by Coutard and colleagues at the monobasic R residue [ 4 ], as marked in Fig. 1 . Following cleavage or priming, the protein is divided into an N-terminal S1-ectodomain that recognizes a cognate cell surface receptor to aid trafficking into and hijacking the host cell, and a C-terminal S2 membrane-anchored protein involved in viral entry [ 4 , 6 ]. The cleavage at the furin-like cleavage site occurs during virus egress for S-protein priming and may provide a gain-of-function to the virus for efficient pathogenesis compared to other betacoronaviruses lineages [ 4 ]. The SWISS-MODEL provides global and local quality assessment for the modeled sequences. The models were highly reliable, with very high GMQE scores. Still, the global and local quality scores are different even after normalization (Fig. 2 ), that furtherly affect the biochemical profiles of the models (Table 3 ). The highly descriptive ProtParam tool of ExPASy provides some answers to such different quality profiles between models. All the models had no Tryptophan residues that could result in more than 10% error in the computed extinction coefficient. The extinction coefficients of the Tunisian and Iranian models were much higher compared to the Chinese models but with declining absorbance scores that are related to their molecular weight. The extinction coefficient is important when studying protein-protein and protein-ligand interactions [ 20 ]. The Iranian models had more than 20 hours’ half-life in both mammalian reticulocytes in vitro and the yeast in vivo, in comparison to other models (Table 3 ), which may be related to the nonpolar N-terminal (Proline) that attached the uncharged side group. The in vivo half-life predicts the elapsed time it takes for half of the protein amount in a cell to disappear after its synthesis. ProtParam relies on the (N-end rule), which relates the half-life of a protein to the N-terminal residue identity that affects the stability of the protein in vivo; the prediction is given for 3 model organisms (human, yeast and E. coli) [ 20 ]. All models share a high aliphatic index that may contribute as a positive factor to increase the relative thermostability of the globular proteins [ 22 ]. All the models were hydrophilic, which is reflected by the highly negative GRAVY score [ 23 ], with the Tunisian model, the most hydrophilic one. Conclusions The S glycoproteins are not identical nor unique in model structure nor the physicochemical profiles in different parts of the world, with a special emphasis on the Tunisian S glycoprotein models, which had drastic biodiversity from the Chinese and Iranian models. Understanding spike protein models is fundamental to an understanding of viral pathogenesis, which will allow for additional protein-engineering efforts that could improve antigenicity and protein expression for pharmaceutical development. Abbreviations ACE 2: Angiotensin-converting enzyme 2. EMBL-EBI: European Molecular Biology Laboratory- European Bioinformatics Institute. GMQE: Global Model Quality Estimation. QMEAN: Qualitative Model Energy Analysis. SARS-COV-2: SARS coronavirus. Declarations Availability of data and materials The datasets used during the current study are available from the corresponding author on reasonable request. Ethics declarations Ethics approval and consent to participate Not applicable. Consent to publication Not applicable. Competing interests The authors declare no competing interests financial or otherwise related to this project. Funding This study received no specific funding. Authors’ contribution SAO and HAA conceived the study. SAO performed data analysis and generated sequence data. SAO and HAA wrote the manuscript. Both authors read, revised, and approved the final draft. Acknowledgment The authors would like to thank all the international researchers and scientists who pioneered the work of sequencing the SARS-CoV-2 genome, who were greatly influential in the research field. References de Haan CA, Kuo L, Masters PS, Vennema H, Rottier PJ. Coronavirus particle assembly: primary structure requirements of the membrane protein. 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Tables Table 1: The GenBank data for the amino acid sequences of 12 S glycoprotein of SARS-CoV-2 isolates from China, Iran, and Tunisia. GenBank Accession Surface Glycoprotein (S) Gene CDS Definition Base Pairs 1 Protein ID Amino Acids Collection Date 5 Isolation Source Locality 1 MN938387 .1 2019-nCoV_HKU-SZ-001_2020 2 107 QHN73805.1 35 2020-01 nasopharyngeal swab China: Shenzhen 1 2 MN938388 .1 2019-nCoV_HKU-SZ-002b_2020 2 107 QHN73806.1 35 2020-01 Serum China: Shenzhen 2 3 MN938389 .1 2019-nCoV_HKU-SZ-004_2020 2 107 QHN73807.1 35 2020-01 nasopharyngeal swab China: Shenzhen 3 4 MN938390 .1 2019-nCoV_HKU-SZ-005_2020 2 107 QHN73808.1 35 2020-01 Throat swab China: Shenzhen 4 5 MN975266 .1 2019-nCoV_HKU-SZ-007a_2020 2 107 QHN73822.1 35 2020-01 nasopharyngeal swab China: Shenzhen 5 6 MN975267 .1 2019-nCoV_HKU-SZ-007b_2020 2 107 QHN73823.1 35 2020-01 Throat swab China: Shenzhen 6 7 MN975268 .1 2019-nCoV_HKU-SZ-007c_2020 2 107 QHN73824.1 35 2020-01 Sputum China: Shenzhen 7 8 MT232871 .1 SARS-CoV-2/human/IRN/MHKN-1/2020 3 157 QIQ08768.1 52 2020-02-26 nasopharyngeal swab Iran: Tehran 1 9 MT232872 .1 SARS-CoV-2/human/IRN/MHKN-2/2020 3 158 QIQ08769.1 52 2020-02-26 nasopharyngeal swab Iran: Tehran 2 10 MT308701 .1 SARS-CoV-2/human/TUN/Tunis7266/2020 493 QIV64962.1 163 2020-04-02 nasopharyngeal swab Tunisia: Tunis 1 11 MT324679 .1 SARS-CoV 2/human/TUN/Tunis_6401/2020 4 491 QIZ14987.1 163 2020-03-29 nasopharyngeal swab Tunisia: Tunis 2 12 MT324680 .1 SARS-CoV-2/human/TUN/Tunis_7643/2020 4 491 QIZ14988.1 163 2020-04-03 nasopharyngeal swab Tunisia: Tunis 3 Abbreviations: CDS, coding sequence; HKU, Hong Kong University; ID, identity; IRN, Iran; kDa, kilodalton; MHKN, Mohammad Hadi Karbalaie Niya; MW, molecular weight; nCoV, novel coronavirus; SARS, severe acute respiratory syndrome; SZ, Shenzhen; TUN, Tunisia. 1 All the original sequencing uses Sanger Dideoxy Sequencing Technique. 2 Identical proteins from (Wuhan seafood market pneumonia virus) from China. 3 Identical proteins from (Severe acute respiratory syndrome coronavirus 2) from Iran. 4 Identical proteins from (Severe acute respiratory syndrome coronavirus 2) from Tunisia. 5 The order of arrangement in the collection date is the order of appearance in the GenBank. Table 2: Percent Identity Matrix created by Clustal 2.1. describes the percentage of similarity between the 12 amino acid sequences. China 1 China 2 China 3 China 4 China 5 China 6 China 7 Iran 1 Iran 2 Tunisia 1 Tunisia 2 Tunisia 3 Protein ID QHN73805.1 QHN73806.1 QHN73807.1 QHN73808.1 QHN73822.1 QHN73823.1 QHN73824.1 QIQ08768.1 QIQ08769.1 QIV64962.1 QIZ14987.1 QIZ14988.1 1 QHN73805.1 100 100 100 100 100 100 100 100 100 25 25 25 2 QHN73806.1 100 100 100 100 100 100 100 100 100 25 25 25 3 QHN73807.1 100 100 100 100 100 100 100 100 100 25 25 25 4 QHN73808.1 100 100 100 100 100 100 100 100 100 25 25 25 5 QHN73822.1 100 100 100 100 100 100 100 100 100 25 25 25 6 QHN73823.1 100 100 100 100 100 100 100 100 100 25 25 25 7 QHN73824.1 100 100 100 100 100 100 100 100 100 25 25 25 8 QIQ08768.1 100 100 100 100 100 100 100 100 100 29.27 29.27 29.27 9 QIQ08769.1 100 100 100 100 100 100 100 100 100 29.27 29.27 29.27 10 QIV64962.1 25 25 25 25 25 25 25 29.27 29.27 100 99.39 99.39 11 QIZ14987.1 25 25 25 25 25 25 25 29.27 29.27 99.39 100 100 12 QIZ14988.1 25 25 25 25 25 25 25 29.27 29.27 99.39 100 100 Table 3: The comparison of the biochemical profiles of the amino acid sequences of 12 S glycoproteins of the SARS-CoV-2 by the use of the ProtParam tool of ExPASy. Parameters China 1-7 1 Iran 1-2 1 Tunisia 1 1 Tunisia 2-3 1 Molecular weight (kDa) 3.93 5.76 17.67 17.67 2 Number of negatively charged amino acids (Asp + Glu) 6 7 13 12 Number of positively charged amino acids (Arg + Lys) 4 5 15 15 Chemical formula C 174 H 267 N 47 O 57 C 257 H 396 N 66 O 80 S 2 C 777 H 1252 N 222 O 238 S 5 NA Total number of atoms 545 801 2494 NA Tryptophan residue availability No No No No Extinction coefficients (M -1 cm -1 ) 4470 4595 3 4595 3 4595 3 Absorbance Abs 0.1% (=1 g/l) 1.138 0.799 0.26 0.26 N-terminal 4 N (Asn) P (Pro) Q (Gln) Q (Gln) The estimated half-life Mammalian reticulocytes, in vitro 1.4 h >20 h 0.8 h 0.8 h Yeast, in vivo 3 min >20 h 10 min 10 min Escherichia coli, in vivo >10 h NA 10 h 10 h The instability index (II) 17.20 (Stable) 5.79 (Stable) 49.67 (Unstable) 47.19 (Unstable) Aliphatic index 78.00 82.50 94.54 94.54 GRAVY score -0.671 -0.188 -0.050 -0.029 Abbreviations: h, hours; GRAVY, Grand average of hydropathicity; kDa, kilodaltons; min, minutes; NA, not available. 1 China 1-7 includes identical sequences (QHN73805.1, QHN73806.1, QHN73807.1, QHN73808.1, QHN73822.1, QHN73823.1, QHN73824.1). Iran 1-2 includes identical sequences (QIQ08768.1 and QIQ08769.1). Tunisia 1 includes the sequence (QIV64962.1), which shares no identity. Tunisia 2-3 includes identical sequences (QIZ14987.1 and QIZ14988.1). 2 The molecular weight is calculated for 163 amino acids using ExPASy is 17.67 kDa. Protein Molecular Weight - Bioinformatics.org tool calculates the molecular weight for 162 amino acids only to be (17.56 kDa), excluding the unknown amino acid. 3 Assuming all pairs of Cys residues form cystines. While if assuming all Cys residues are reduced, the extinction coefficient will be 4470 M -1 cm -1 , and the absorbance will be 0.777 for the Iranian models (1-2), and 0.253 for all the Tunisian models. 4 The N-terminal of the Chinese models is polar with a positively charged side group. The Iranian models had nonpolar N-terminal with an uncharged side group. The N-terminal residues of the Tunisian models are polar with an uncharged side group. Supplementary Files SupplementaryFigures.docx SupplementaryFigures.docx GraphicAbstract.docx GraphicAbstract.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-63469","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":1837379,"identity":"fb148050-2ccd-48fd-970d-b8669c598339","order_by":0,"name":"Samih A. Odhaib","email":"","orcid":"","institution":"University of Basrah College of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Samih","middleName":"A.","lastName":"Odhaib","suffix":""},{"id":1837380,"identity":"53e5273f-7b6c-4b3f-b784-2030b0f6e9c0","order_by":1,"name":"Hayder Al-Aubaidy","email":"data:image/png;base64,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","orcid":"https://orcid.org/0000-0001-9564-0120","institution":"La Trobe University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Hayder","middleName":"","lastName":"Al-Aubaidy","suffix":""}],"badges":[],"createdAt":"2020-08-21 10:34:42","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-63469/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-63469/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":2183399,"identity":"05afdcd5-d652-43c3-8e8f-393d9b0cee73","added_by":"auto","created_at":"2020-09-01 15:25:22","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":186030,"visible":true,"origin":"","legend":"Multiple sequence alignment of the amino acid sequences for 12 S glycoproteins of SARS-CoV-2 from China (seven sequences), Iran (two sequences), and Tunisia (three sequences) using Clustal Omega.\nThe red arrow marks the ambiguous sites of the unidentified amino acid of the Tunisian sequences. Asterisks represent fully conserved residues, colons represent highly conserved residues, and periods represent lowly conserved residues. The black arrow marks the possible S1/S2 furin-like cleavage site.\n","description":"","filename":"Onlinefloatimage1.Png","url":"https://assets-eu.researchsquare.com/files/rs-63469/v1/Onlinefloatimage1.Png"},{"id":2183400,"identity":"fd3c150b-6dfa-42d3-9e34-8184adf00586","added_by":"auto","created_at":"2020-09-01 15:25:23","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":60156,"visible":true,"origin":"","legend":"Local quality estimates comparison of the amino acid sequences of the three S glycoproteins in China, Iran, and Tunisia.\nFor panels (A, B, and C), the x-axis shows protein length (number of residues). For panel (D), the y-axis is the normalized QMEAN score. Every dot in panel (D) represents one experimental protein structure. The red stars represent the actual models normalized QMEAN score.\n","description":"","filename":"Onlinefloatimage2.Png","url":"https://assets-eu.researchsquare.com/files/rs-63469/v1/Onlinefloatimage2.Png"},{"id":13586718,"identity":"e7b53be0-1b0f-4e30-93a8-9d0bfa1f04f8","added_by":"auto","created_at":"2021-09-17 04:48:13","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1570961,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-63469/v1/36fdd549-a3ff-48cf-a612-4d6c36249c06.pdf"},{"id":2183402,"identity":"04bd1ee0-9adb-4da6-bbec-7b8edb567097","added_by":"auto","created_at":"2020-09-01 15:25:23","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":876312,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryFigures.docx","url":"https://assets-eu.researchsquare.com/files/rs-63469/v1/SupplementaryFigures.docx"},{"id":2183395,"identity":"8c81954e-03d0-4962-b12f-0d1d34c4cec9","added_by":"auto","created_at":"2020-09-01 15:25:17","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":876312,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryFigures.docx","url":"https://assets-eu.researchsquare.com/files/rs-63469/v1/SupplementaryFigures.docx"},{"id":2183403,"identity":"d62fc5d0-0e12-4c66-8ce0-bdf4f21e9801","added_by":"auto","created_at":"2020-09-01 15:25:23","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":421635,"visible":true,"origin":"","legend":"","description":"","filename":"GraphicAbstract.docx","url":"https://assets-eu.researchsquare.com/files/rs-63469/v1/GraphicAbstract.docx"},{"id":2183396,"identity":"10d222e8-1d41-4f26-90d7-071212d65050","added_by":"auto","created_at":"2020-09-01 15:25:17","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":421635,"visible":true,"origin":"","legend":"","description":"","filename":"GraphicAbstract.docx","url":"https://assets-eu.researchsquare.com/files/rs-63469/v1/GraphicAbstract.docx"}],"financialInterests":"","formattedTitle":"The physicochemical and phylogenetic properties of twelve spike glycoprotein models for SARS-CoV-2 from China, Iran, and Tunisia","fulltext":[{"header":"Highlights","content":"\u003cul\u003e\n\u003cli\u003eThe coronavirus spike glycoprotein facilitates the viral adhesion to the susceptible human cells and may contribute to its virulence.\u003c/li\u003e\n\u003cli\u003eThe spike glycoprotein is the main inducer of neutralizing antibodies.\u003c/li\u003e\n\u003cli\u003eWhat\u0026rsquo;s New:\u003c/li\u003e\n\u003cli\u003eAlthough the different COVID-19 spike glycoproteins from different countries are monophyletic, they are not identical nor unique in model structure nor the physicochemical properties.\u003c/li\u003e\n\u003cli\u003eThe stable Chinese and Iranian sequence models of the glycoprotein shared 100% identity, while they shared 25-29.27% to unstable Tunisian models.\u003c/li\u003e\n\u003c/ul\u003e"},{"header":"Background","content":" \u003cp\u003eSARS coronavirus (SARS-CoV-2) is a spherical pleomorphic enveloped particle, containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. The envelope bears spike (S) glycoprotein [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThis S-glycoprotein is trimeric and consists of three S1-S2 heterodimers that determine the adhesion and viral virulence through its ability to attach different receptors with a distinctive affinity to the angiotensin-converting enzyme 2 (ACE-2) receptors on the human cell surface [ 2, 3]. During viral infection, the S glycoprotein is cleaved into S1 and S2 subunits at a furin-like cleavage site through a cascade of proteolytic enzymes [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. S1 subunit determines the virus-host range and cellular tropism through the receptor-binding domain (RBD) and N-terminal domain to bind directly to the ACE-2 receptor [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e], which serve as a functional receptor for this virus [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. S2 subunit acts as a class I viral fusion protein and mediates virus-cell membrane fusion by two heptad repeats [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe viral adhesion to the host cell involves a complex pre- to post-fusion conformation transition [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e], and it is ten times tighter than the corresponding S protein of other coronaviruses to their corresponding receptors [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe S glycoprotein is a surface protein and acts as the main inducer of neutralizing antibodies, T-cell response, and possible protective immunity, which make this protein a target for therapeutic intervention and vaccine development [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThis study highlighted the genomic and phylogenetic properties of SARS-CoV-2 spike glycoprotein sequences from three countries China, Iran, and Tunisia.\u003c/p\u003e "},{"header":"Materials And Methods","content":" \u003cp\u003eThis is a descriptive cross-sectional comparative study analyzing the genomic and phylogenetic properties of S glycoprotein from 12 SARS-CoV-2 specimens from China (seven isolates), Iran (two isolates), and Tunisia (three isolates). The genomic coding and amino acid sequences of the SARS-CoV-2 are available in the GenBank (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.ncbi.nlm.nih.gov/genbank/sars-cov-2-seqs/\u003c/span\u003e\u003c/span\u003e\u003cspan type=\"BoldUnderline\" class=\"BoldUnderline\" name=\"Emphasis\"\u003e)\u003c/span\u003e [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. The identical proteins were identified by the (Identical Protein Group) to simplify the evaluation by choosing one descriptive representative sequence from each country.\u003c/p\u003e \u003cp\u003eThe (Multiple Sequence Alignment) at Clustal Omega (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.ebi.ac.uk/Tools/msa/clustalo/\u003c/span\u003e\u003c/span\u003e\u003cspan type=\"BoldUnderline\" class=\"BoldUnderline\" name=\"Emphasis\"\u003e)\u003c/span\u003e of the European Molecular Biology Laboratory- European Bioinformatics Institute (EMBL-EBI) [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e] was used to study amino acid sequences alignment of the 12 sequences. Clustal Omega tools can determine any conserved residues in the 12 models.\u003c/p\u003e \u003cp\u003eThe Phylogenetic Tree and Percent Identity Matrix were used to study the nature and the percentage of the similarity between the 12 sequences. The phylogenetic tree (phylogeny) is a diagram that depicts the lines of evolutionary descent in the protein sequences. A phylogenetic tree portrays the branching history of common ancestry, and the pattern of branching using cladograms and phylogram. The branching pattern reflects different evolutionary lineages [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eWe chose three amino acid sequences with the highest protein identities (QHN73805.1, QIQ08768.1, and QIV64962.1) from (China, Iran, and Tunisia) respectively, for developing and validating 3D sequence models using the SWISS-MODEL (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://swissmodel.expasy.org/interactive#structure\u003c/span\u003e\u003c/span\u003e\u003cspan type=\"BoldUnderline\" class=\"BoldUnderline\" name=\"Emphasis\"\u003e)\u003c/span\u003e, along with the structural assessment tools to confirm the structured model [\u003cspan additionalcitationids=\"CR16\" citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe Tunisian protein sequences (QIZ14987.1 and QIZ14988.1) of Tunisia are identical. Still, we could not include any of their sequences because they contain unidentified amino acids at an abnormal position, which makes them unsuitable for modeling by the SWISS-MODEL [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe sequence modeling for the chosen proteins was evaluated according to their local and global quality estimates by the use of:\u003c/p\u003e \u003cp\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eGlobal Model Quality Estimation (GMQE) reflects modeling accuracy and reliability. The resulting score is expressed as a number between 0 and 1; the higher the number was, the more the reliability was [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e].\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eQualitative Model Energy Analysis (QMEAN): The composite estimator of the different geometrical properties of the protein sequence that provides both global (for the entire structure) and local (per residue) absolute quality estimates based on one single model [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e].\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eThe QMEAN Z-score estimates the \"degree of nativeness\" of the structural features observed in the model on a global scale. The QMEAN Z-score compares the model QMEAN score to the scores of the similar size expected experimental structures, through Cβ atoms only, all atoms, the solvation potential, and the torsion angle potential [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e].\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eThe QMEANDisCo enhances the accuracy of the QMEAN local scores by assessing the interatomic distance of the target model against the already ensemble information of the experimentally determined proteins that share homology to the target model [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e].\u003c/p\u003e \u003c/li\u003e \u003c/ul\u003e \u003c/p\u003e \u003cp\u003eProtParam tool at the ExPASy proteomics server (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://web.expasy.org/protparam/\u003c/span\u003e\u003c/span\u003e\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e)\u003c/span\u003e was used to study and computes various physicochemical properties of a protein sequence [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. It provides information about different indices and scores:\u003c/p\u003e \u003cp\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eMolecular weight.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eThe number and charges of different amino acid residues.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eThe chemical formula.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eTryptophan residues availability.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eSite and type of N-terminal residues.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eExtinction coefficients indicate how much light a protein absorbs at a particular wavelength, which is useful during the purification process. Optical density (Absorbance) which is the product of dividing the extinction coefficient by the molecular weight [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e].\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eIn vivo half-life.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eInstability index (II) which provides an estimate of the stability of your protein in a test tube. The (II) of stable proteins is \u0026lt;\u0026thinsp;40, while for unstable proteins, the (II)\u0026thinsp;\u0026gt;\u0026thinsp;40.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eThe aliphatic index is the relative volume occupied by aliphatic side chains (alanine, valine, isoleucine, and leucine) [\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e].\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eGrand Average of Hydropathy (GRAVY) marks the protein as hydrophilic (negative values) or hydrophobic (positive values) [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e].\u003c/p\u003e \u003c/li\u003e \u003c/ul\u003e \u003c/p\u003e \u003cp\u003eThe Protein Molecular Weight \u0026ndash; The Sequence Manipulation Suite at Bioinformatics.org (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.bioinformatics.org/sms/prot_mw.html\u003c/span\u003e\u003c/span\u003e\u003cspan type=\"BoldUnderline\" class=\"BoldUnderline\" name=\"Emphasis\"\u003e)\u003c/span\u003e was used to compare the actual molecular weight of different protein sequences, without including any unknown amino acids [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e].\u003c/p\u003e "},{"header":"Results","content":"\u003cp\u003eTable 1 demonstrates the GenBank accession numbers of AA sequences of the 12 S glycoproteins of the SARS-CoV-2 from China, Iran, and Tunisia (this represent the whole worldwide plotted sequences until April 20th, 2020).\u0026nbsp; The Tunisian sequences had the most abundant amino acid number in comparison to the Iranian and Chinese sequences. The sequences (QIZ14987.1 and QIZ14988.1) are identical, and they contain an abnormal amino acid at an ambiguous position. The Identical Protein Group provides information about the identical protein sequences from each country. All the Chinese sequences are shown in Table 1, were isolated on the same day (February 11th, 2020) from the (Wuhan seafood market pneumonia virus), from the nasopharyngeal swab, serum, throat swab, and sputum. All other sequences from Iran and Tunisia were taken from the nasopharyngeal swabs.\u003c/p\u003e\n\u003cp\u003eFigure 1 demonstrates the multiple sequence alignment of different sequences. There are six fully, three highly, and five lowly conserved residues. The Chinese and the Iranian sequences share 100% similarity, while the Tunisian sequences had 25 and 29.27% similarity to the Chinese and the Iranian sequences, respectively. The first Tunisian sequence described (QIV64962.1) had 99.39% similarity to the other two sequences (QIZ14987.1 and QIZ14988.1) because of the unidentified amino acid at the ambiguous position (Table 2, and Figure 1).\u003c/p\u003e\n\u003cp\u003eThe first divergence event separated the lineage that gave rise to the (China-Shenzhen 7) sequence from a lineage of the other six Chinese sequences and a lineage that gave rise to the Iranian and Tunisian sequences, i.e., the 12 sequences shared a common ancestry (monophyletic group). The (China-Shenzhen 1 and 2) share a more recent common ancestor than either share with other sequences, i.e., they are therefore more closely related to each other than either is to other sequences. The (Tunisia-Tunis 2 and 3) sequences underwent recent evolutionary divergence that occurred (Supplementary Figure 1 A and B).\u003c/p\u003e\n\u003cp\u003eBecause all the Chinese and Iranian sequences are of equal distance (in terms of branch arrangement) from their original ancestor, we could say that these sequences are equally related to each other. The three Tunisian sequences underwent the most recent divergence from the original evolutionary lineage.\u003c/p\u003e\n\u003cp\u003eThe 3D models of the S glycoproteins from the three chosen sequences from the three countries were highly reliable models with a very high GMQE score. Still, they demonstrated that the very low global quality, very low QMEAN-scored Tunisian S glycoprotein had three chains in comparison to the Chinese sequence of medium global quality and the Iranian sequences of the highest global quality between the three countries. The Z-scores of all three sequences fall within the range between (0.5-0.7) (Figure 2 and Supplementary Figure 2).\u003c/p\u003e\n\u003cp\u003eThe Tunisian sequences had the highest molecular weight, extinction index, and instability index (II) between the chosen sequences, which renders the Tunisian sequences unstable in comparison to both the Chinese and the Iranian sequences, which are relatively stable at different degrees. All the sequences are hydrophilic and share a high aliphatic index (Table 3).\u003c/p\u003e\n\u003cp\u003eThe N-terminals which signify the beginning of the S1 subunit of the S glycoprotein in SARS-CoV-2 are different in their chemical profiles:\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor the Chinese sequences, it is N (Asparagine), which is polar with a positively charged side group.\u003c/li\u003e\n\u003cli\u003eFor the Iranian sequences, it is P (Proline), which is nonpolar with an uncharged side group.\u003c/li\u003e\n\u003cli\u003eFor the Tunisian sequences, it is Q (Glutamine), which is polar with an uncharged side group.\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003eThese biophysical changes affect the half-life of the protein models in vitro and in vivo (Table 3).\u003c/p\u003e"},{"header":"Discussion","content":" \u003cp\u003eThe coronavirus S glycoprotein is an important structural protein that is responsible for the phenotype of crown-like shape viral particles, from which the original name \u0026ldquo;coronavirus\u0026rdquo; was coined [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe GenBank provides unrestricted access to all types of genomic and polypeptide sequences that dealt with the novel coronavirus epidemic by SARS-CoV-2 [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Till the preparation of this paper (April 20th, 2020), only the Chinese sequences of S glycoprotein of SARS-CoV-2 were assessed and compared through the literature [\u003cspan additionalcitationids=\"CR26\" citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. The Iranian and the Tunisian sequences were not assessed after being uploaded in the GenBank.\u003c/p\u003e \u003cp\u003eThe three Tunisian models represent the largest S glycoprotein unit, in comparison to the Chinese and Iranian S glycoproteins, with their higher number of base pairs and a consequently higher number of amino acid residues. Even though the assessment of the Percent Identity Matrix by Clustal 2.1. revealed a 100% similarity or identity between the Chinese and the Iranian sequences, although the numbers of amino acid residues are different. Two out of the three Tunisian sequences (QIZ14987.1 and QIZ14988.1) were identical 100% but share a 25% identity with the Chinese and Iranian sequences. The presence of an unknown amino acid (X) at an ambiguous position in these sequences minimally decreased the identity of the sequences (QIZ14987.1 and QIZ14988.1) to the third Tunisian sequence (QIV64962.1) by 0.61% to be 99.39%. on the other hand, the Tunisian sequence (QIV64962.1) shared a 29.27% identity with the Chinese and Iranian sequences. Shanker and colleagues had studied the amino acid sequences of the seven S glycoprotein units from China and reached the same conclusion [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe N-terminal identifies the start of the S1 subunit in the three modeled sequences. There was a different polarity for the N-terminal residues, being polar with a positively charged side group in the Chinese model, nonpolar with uncharged side group in the Iranian model, and polar with uncharged side group in the Tunisian model [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe S glycoprotein remains uncleaved at the S1/S2 site during virus packaging in cells. The trimetric S-protein is processed at the S1/S2 furin-like cleavage site by host cell proteases, during infection [\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]. We combined the SWISS-MODEL and the Clustal Omega modeling to find the possible furin-like S1/S2 cleavage site that was thoroughly described by Coutard and colleagues at the monobasic R residue [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e], as marked in Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e.\u003c/p\u003e \u003cp\u003eFollowing cleavage or priming, the protein is divided into an N-terminal S1-ectodomain that recognizes a cognate cell surface receptor to aid trafficking into and hijacking the host cell, and a C-terminal S2 membrane-anchored protein involved in viral entry [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. The cleavage at the furin-like cleavage site occurs during virus egress for S-protein priming and may provide a gain-of-function to the virus for efficient pathogenesis compared to other betacoronaviruses lineages [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe SWISS-MODEL provides global and local quality assessment for the modeled sequences. The models were highly reliable, with very high GMQE scores. Still, the global and local quality scores are different even after normalization (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003e), that furtherly affect the biochemical profiles of the models (Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThe highly descriptive ProtParam tool of ExPASy provides some answers to such different quality profiles between models. All the models had no Tryptophan residues that could result in more than 10% error in the computed extinction coefficient. The extinction coefficients of the Tunisian and Iranian models were much higher compared to the Chinese models but with declining absorbance scores that are related to their molecular weight. The extinction coefficient is important when studying protein-protein and protein-ligand interactions [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe Iranian models had more than 20 hours\u0026rsquo; half-life in both mammalian reticulocytes in vitro and the yeast in vivo, in comparison to other models (Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e), which may be related to the nonpolar N-terminal (Proline) that attached the uncharged side group. The in vivo half-life predicts the elapsed time it takes for half of the protein amount in a cell to disappear after its synthesis. ProtParam relies on the (N-end rule), which relates the half-life of a protein to the N-terminal residue identity that affects the stability of the protein in vivo; the prediction is given for 3 model organisms (human, yeast and E. coli) [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eAll models share a high aliphatic index that may contribute as a positive factor to increase the relative thermostability of the globular proteins [\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. All the models were hydrophilic, which is reflected by the highly negative GRAVY score [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e], with the Tunisian model, the most hydrophilic one.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThe S glycoproteins are not identical nor unique in model structure nor the physicochemical profiles in different parts of the world, with a special emphasis on the Tunisian S glycoprotein models, which had drastic biodiversity from the Chinese and Iranian models. Understanding spike protein models is fundamental to an understanding of viral pathogenesis, which will allow for additional protein-engineering efforts that could improve antigenicity and protein expression for pharmaceutical development.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cul\u003e\n\u003cli\u003eACE 2: Angiotensin-converting enzyme 2.\u003c/li\u003e\n\u003cli\u003eEMBL-EBI: European Molecular Biology Laboratory- European Bioinformatics Institute.\u003c/li\u003e\n\u003cli\u003eGMQE: Global Model Quality Estimation.\u003c/li\u003e\n\u003cli\u003eQMEAN: Qualitative Model Energy Analysis.\u003c/li\u003e\n\u003cli\u003eSARS-COV-2: SARS coronavirus.\u003c/li\u003e\n\u003c/ul\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics declarations\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests financial or otherwise related to this project.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study received no specific funding.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contribution\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSAO and HAA conceived the study. SAO performed data analysis and generated sequence data. SAO and HAA wrote the manuscript. Both authors read, revised, and approved the final draft.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgment\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank all the international researchers and scientists who pioneered the work of sequencing the SARS-CoV-2 genome, who were greatly influential in the research field.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003ede Haan CA, Kuo L, Masters PS, Vennema H, Rottier PJ. Coronavirus particle assembly: primary structure requirements of the membrane protein. J Virol 1998 Aug; 72(8): 6838\u0026ndash;50. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109893/\"\u003ehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC109893/\u003c/a\u003e. PMID: 9658133; PMCID: PMC109893.\u003c/li\u003e\n\u003cli\u003eTortorici MA, Veesler D. Structural insights into coronavirus entry. 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PMID: 15367599; PMCID: PMC516425.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin: 0in -0.05pt 8pt 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eTable 1: The GenBank data for the amino acid sequences of 12 S glycoprotein of SARS-CoV-2 isolates from China, Iran, and Tunisia.\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;border: none;\" width=\"690\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border: 1pt solid windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eGenBank Accession\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eSurface Glycoprotein (S) Gene\u003c/strong\u003e\u003cstrong\u003eCDS Definition\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eBase Pairs\u003csup\u003e1\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eProtein ID\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eAmino Acids\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eCollection Date\u003csup\u003e5\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eIsolation Source\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eLocality\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MN938387\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMN938387\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;background-color: white;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2019-nCoV_HKU-SZ-001_2020\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73805.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChina: Shenzhen 1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MN938388\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMN938388\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;background-color: white;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2019-nCoV_HKU-SZ-002b_2020\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73806.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSerum\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChina: Shenzhen 2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MN938389\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMN938389\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;background-color: white;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2019-nCoV_HKU-SZ-004_2020\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73807.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChina: Shenzhen 3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MN938390\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMN938390\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2019-nCoV_HKU-SZ-005_2020\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73808.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eThroat swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChina: Shenzhen 4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MN975266\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMN975266\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2019-nCoV_HKU-SZ-007a_2020\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73822.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChina: Shenzhen 5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MN975267\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMN975267\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2019-nCoV_HKU-SZ-007b_2020\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73823.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eThroat swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChina: Shenzhen 6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MN975268\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMN975268\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;background-color: white;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2019-nCoV_HKU-SZ-007c_2020\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73824.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSputum\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChina: Shenzhen 7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MT232871\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMT232871\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;background-color: white;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSARS-CoV-2/human/IRN/MHKN-1/2020\u003csup\u003e3\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e157\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQIQ08768.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-02-26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eIran: Tehran 1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MT232872\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMT232872\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;background-color: white;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSARS-CoV-2/human/IRN/MHKN-2/2020\u003csup\u003e3\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e158\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQIQ08769.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-02-26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eIran: Tehran 2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MT308701\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMT308701\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSARS-CoV-2/human/TUN/Tunis7266/2020\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e493\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQIV64962.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e163\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-04-02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eTunisia: Tunis 1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MT324679\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMT324679\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSARS-CoV 2/human/TUN/Tunis_6401/2020\u003csup\u003e4\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e491\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQIZ14987.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e163\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-03-29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eTunisia: Tunis 2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 21.05pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"4.063860667634253%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.15pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"11.030478955007258%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/nuccore/MT324680\"\u003e\u003cstrong\u003e\u003cspan style=\"background-color: white;\"\u003eMT324680\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cu\u003e.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"20.4644412191582%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSARS-CoV-2/human/TUN/Tunis_7643/2020\u003csup\u003e4\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e491\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.4pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.88534107402032%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQIZ14988.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"8.272859216255442%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e163\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.85pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"9.57910014513788%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"background-color: white;\"\u003e2020-04-03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"12.336719883889696%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003enasopharyngeal swab\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"15.09433962264151%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eTunisia: Tunis 3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eAbbreviations: CDS, coding sequence; HKU, Hong Kong University; ID, identity; IRN, Iran; kDa, kilodalton; MHKN, Mohammad Hadi Karbalaie Niya; MW, molecular weight; nCoV, novel coronavirus; SARS, severe acute respiratory syndrome; SZ, Shenzhen; TUN, Tunisia.\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e1\u0026nbsp;\u003c/sup\u003e\u003c/em\u003e\u003cem\u003eAll the original sequencing uses Sanger Dideoxy Sequencing Technique.\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e2\u0026nbsp;\u003c/sup\u003e\u003c/em\u003e\u003cem\u003eIdentical proteins from (Wuhan seafood market pneumonia virus) from China.\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e3\u0026nbsp;\u003c/sup\u003e\u003c/em\u003e\u003cem\u003eIdentical proteins from (Severe acute respiratory syndrome coronavirus 2) from Iran.\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e4\u0026nbsp;\u003c/sup\u003e\u003c/em\u003e\u003cem\u003eIdentical proteins from (Severe acute respiratory syndrome coronavirus 2) from Tunisia.\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e5\u003c/sup\u003e\u003c/em\u003e\u003cem\u003e\u0026nbsp;The order of arrangement in the collection date is the order of appearance in the GenBank.\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTable 2: Percent Identity Matrix created by Clustal 2.1. describes the percentage of similarity between the 12 amino acid sequences.\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;border: none;\" width=\"105%\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 13.1875px;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"3.0927835051546393%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.15625px;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"10.309278350515465%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 1\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 2\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 3\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 4\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 5\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 6\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 7\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.875px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eIran 1\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.875px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eIran 2\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.65625px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTunisia 1\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.03125px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTunisia 2\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.03125px;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;padding: 0in 5.4pt;\" width=\"7.216494845360825%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTunisia 3\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.15625px;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"10.638297872340425%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eProtein ID\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"7.446808510638298%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73805.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"7.446808510638298%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73806.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"7.446808510638298%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cu\u003eQHN73807.1\u003c/u\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15625px;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"7.446808510638298%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 8pt 0in;line-height: 29.333335876464844px;font-size:15px;font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 32px;\"\u003eTable 3: The comparison of the biochemical profiles of the amino acid sequences of 12 S glycoproteins of the SARS-CoV-2 by the use of the ProtParam tool of ExPASy.\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;border: none;\" width=\"775\"\u003e\n \u003ctbody\u003e\n 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width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChina 1-7\u003csup\u003e1\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;background-color: rgb(217, 217, 217);padding: 0in 5.4pt;background-position: initial initial;background-repeat: initial initial;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eIran 1-2\u003csup\u003e1\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;background-color: rgb(217, 217, 217);padding: 0in 5.4pt;background-position: initial initial;background-repeat: initial initial;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTunisia 1\u003csup\u003e1\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-top-width: 1pt;border-right-width: 1pt;border-bottom-width: 1pt;border-style: solid solid solid none;border-top-color: windowtext;border-right-color: windowtext;border-bottom-color: windowtext;background-color: rgb(217, 217, 217);padding: 0in 5.4pt;background-position: initial initial;background-repeat: initial initial;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTunisia 2-3\u003csup\u003e1\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eMolecular weight (kDa)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3.93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e17.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e17.67\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eNumber of negatively charged amino acids (Asp + Glu)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eNumber of positively charged amino acids (Arg + Lys)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eChemical formula\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eC\u003csub\u003e174\u003c/sub\u003eH\u003csub\u003e267\u003c/sub\u003eN\u003csub\u003e47\u003c/sub\u003eO\u003csub\u003e57\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eC\u003csub\u003e257\u003c/sub\u003eH\u003csub\u003e396\u003c/sub\u003eN\u003csub\u003e66\u003c/sub\u003eO\u003csub\u003e80\u003c/sub\u003eS\u003csub\u003e2\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eC\u003csub\u003e777\u003c/sub\u003eH\u003csub\u003e1252\u003c/sub\u003eN\u003csub\u003e222\u003c/sub\u003eO\u003csub\u003e238\u003c/sub\u003eS\u003csub\u003e5\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTotal number of atoms\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e545\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e801\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2494\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTryptophan residue availability\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNo\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNo\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNo\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNo\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eExtinction coefficients (M\u003csup\u003e-1\u003c/sup\u003e cm\u003csup\u003e-1\u003c/sup\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4470\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4595\u003csup\u003e3\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4595\u003csup\u003e3\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4595\u003csup\u003e3\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eAbsorbance Abs 0.1% (=1 g/l)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.138\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.799\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eN-terminal\u003csup\u003e4\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eN (Asn)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eP (Pro)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eQ (Gln)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eQ (Gln)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width: 113.15pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;height: 0.1in;\" width=\"19.45876288659794%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eThe estimated half-life\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 163.05pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 0.1in;\" width=\"27.963917525773194%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eMammalian reticulocytes, in vitro\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 0.1in;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.4 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 0.1in;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026gt;20 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 0.1in;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.8 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 0.1in;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.8 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"34.72%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eYeast, in vivo\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3 min\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026gt;20 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10 min\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10 min\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 163.05pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"34.72%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eEscherichia coli, in vivo\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026gt;10 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;height: 7.15pt;\" width=\"16.32%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10 h\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eThe instability index (II)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e17.20 (Stable)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5.79 (Stable)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e49.67 (Unstable)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e47.19 (Unstable)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eAliphatic index\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e78.00\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e82.50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e94.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e94.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 276.2pt;border-right-width: 1pt;border-bottom-width: 1pt;border-left-width: 1pt;border-style: none solid solid;border-right-color: windowtext;border-bottom-color: windowtext;border-left-color: windowtext;padding: 0in 5.4pt;\" width=\"47.422680412371136%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eGRAVY score\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e-0.671\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e-0.188\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e-0.050\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.25pt;border-style: none solid solid none;border-bottom-width: 1pt;border-bottom-color: windowtext;border-right-width: 1pt;border-right-color: windowtext;padding: 0in 5.4pt;\" width=\"13.144329896907216%\"\u003e\n \u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e-0.029\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eAbbreviations: h, hours; GRAVY, Grand average of hydropathicity; kDa, kilodaltons; min, minutes; NA, not available.\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e1\u0026nbsp;\u003c/sup\u003e\u003c/em\u003e\u003cem\u003eChina 1-7 includes identical sequences (QHN73805.1, QHN73806.1, QHN73807.1, QHN73808.1, QHN73822.1, QHN73823.1, QHN73824.1). Iran 1-2 includes identical sequences (QIQ08768.1 and QIQ08769.1). Tunisia 1 includes the sequence (QIV64962.1), which shares no identity. Tunisia 2-3 includes identical sequences (QIZ14987.1 and QIZ14988.1).\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e2\u003c/sup\u003e\u003c/em\u003e\u003cem\u003e\u0026nbsp;The molecular weight is calculated for 163 amino acids using ExPASy is 17.67 kDa. Protein Molecular Weight - Bioinformatics.org tool calculates the molecular weight for 162 amino acids only to be (17.56 kDa), excluding the unknown amino acid.\u0026nbsp;\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 0in 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e3\u0026nbsp;\u003c/sup\u003e\u003c/em\u003e\u003cem\u003eAssuming all pairs of Cys residues form cystines. While if assuming all Cys residues are reduced, the extinction coefficient will be 4470 M\u003csup\u003e-1\u003c/sup\u003e cm\u003csup\u003e-1\u003c/sup\u003e, and the absorbance will be 0.777 for the Iranian models (1-2), and 0.253 for all the Tunisian models.\u0026nbsp;\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.05pt 8pt 0in;line-height: normal;font-size:15px;font-family: Calibri, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u003csup\u003e4\u003c/sup\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cem\u003e\u003cspan style=\"font-size: 10px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003e\u0026nbsp;The N-terminal of the Chinese models is polar with a positively charged side group. The Iranian models had nonpolar N-terminal with an uncharged side group. The N-terminal residues of the Tunisian models are polar with an uncharged side group.\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Coronavirus, phylogeny, protein sequences, SWISS-MODEL","lastPublishedDoi":"10.21203/rs.3.rs-63469/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-63469/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eThe coronavirus spike glycoprotein is a trimeric structural surface protein that facilitates the viral adhesion through attaching receptors on the human cell surface. This study aims to analyse and compare the genomic and phylogenetic properties of these spike glycoproteins from China, Iran, and Tunisia.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eThis is a descriptive cross-sectional comparative study for the different properties of S glycoprotein from 12 SARS-CoV-2 specimens from GenBank. Clustal Omega was used to study model sequences alignment, residual conservation, phylogeny, and identity matrix. SWISS-MODEL developed and validated the 3D models for three protein sequences with the highest model quality. The different physicochemical characteristics of different models were assessed by ExPASy proteomics.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThe Chinese and the Iranian sequences share 100% identity, although they have a different amino acids number, and 25-29.27% identity to the Tunisian sequences. The 12 models are monophyletic, with varying stages of evolutionary divergence. There are six fully, three highly, and five lowly conserved residues across the sequences. The resulting three highly reliable 3D models were of different global qualities, being the lowest for the Tunisian, and the highest for the Iranian models. All the models are highly hydrophilic. The Tunisian models were unstable in comparison to the relatively stable other models with different physicochemical characteristics.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eThe models had different N-terminal residues and side groups polarity and charge. The S glycoproteins are not identical nor unique in model structure nor the physicochemical profiles in different parts of the world. The Tunisian models are drastically biodiverse from the Chinese and Iranian models.\u003c/p\u003e","manuscriptTitle":"The physicochemical and phylogenetic properties of twelve spike glycoprotein models for SARS-CoV-2 from China, Iran, and Tunisia","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-09-01 15:25:15","doi":"10.21203/rs.3.rs-63469/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"aa82996a-0aea-437f-b3d0-2a4477321dfc","owner":[],"postedDate":"September 1st, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":407040,"name":"Virology"}],"tags":[],"updatedAt":"2020-09-01T15:25:17+00:00","versionOfRecord":[],"versionCreatedAt":"2020-09-01 15:25:15","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-63469","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-63469","identity":"rs-63469","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}