Effects of Boyanghwano-Tang on the Development of Experimentally-induced Endometriosis in the Rats

Sungmin IM; Dong-Nyung Lee; Il-bok Seo; Hyeong-Jun Kim

doi:10.15204/jkobgy.2010.23.3.056

Effects of Boyanghwano-Tang on the Development of Experimentally-induced Endometriosis in the Rats

Sungmin IM, Dong-Nyung Lee, Il-bok Seo, Hyeong-Jun Kim

In: The Journal of Korean Obstetrics and Gynecology · 2009 · vol. 22(3) , pp. 56–77 · doi:10.15204/jkobgy.2010.23.3.056 · W2547618474

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Bojungikgi-Tang administration significantly reduced endometriotic implant volume and pro-inflammatory cytokines in a rat model by decreasing COX-2 and VEGF expression.

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This study investigated the therapeutic potential of Boyanghwano-Tang, a traditional Korean herbal formulation, on experimentally induced endometriosis in rats. The researchers utilized a surgical model to establish endometriotic lesions and administered the herbal treatment to evaluate its effects on lesion development and associated pathological changes. While specific quantitative outcomes are not detailed in the provided reference list, the paper’s title and context indicate an assessment of how this specific decoction influences the progression of ectopic endometrial tissue growth in the animal model. This paper is centrally about endometriosis — specifically the evaluation of a traditional herbal medicine intervention for surgically induced disease in a rat model.

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Abstract

Purpose: This study was performed to investigate the effects of Bojungikgi-Tang on the development of experimentally-induced endometriosis in rats. Methods: Endometriosis was induced in rats by autotransplanting uterine tissue to the peritoneum and we divided the rats into three groups: (1) sham-operated group (n=8), (2) surgically induced endometriosis and untreated control group(n=8), (3) surgically induced endometriosis and Bojungikgi-Tang treated group. Bojungikgi-Tang was orally administrated for 15 days after operation. Then we measured the body weight, the volume of endometriotic implants, the weight of uterus and ovary, and analysed the concentration of cytokines(MCP-1, TNF-, IL-1, IL-6) in peritoneal fluids. Histopathology, immunohistochemistry for COX-2 and VEGF, and histochemistry for mast cell in transplanted uterine tissue were also performed. Results: 1. The volume() of endometriotic implants in Bojungikgi-Tang treated group(12939) was significantly decreased(p109). 2. The concentration(pg/) of MCP-1 in peritoneal fluids in Bojungikgi-Tang treated group(1012248) was significantly decreased(p346). 3. The concentration(pg/ of TNF- in peritoneal fluids in Bojungikgi-Tang treated group(887196) was significantly decreased(p140). 4. Histopathologically, proliferation of endometriotic epithelia, infiltration of inflammatory cells and angiogenesis in transplanted uterine tissue of Bojungikgi-Tang treated group were weakly observed than those of control group. 5. The percentage of positive epithelial layers for COX-2 in Bojungikgi-Tang treated group(5617) was significantly decreased(p16). 6. The VEGF expression of endometriotic epithelia, neovascular endothelia and stromal cells in transplanted uterine tissue of Bojungikgi-Tang treated group were weakly observed than those of control group. Conclusion: On the basis of these results, we concluded that Bojungikgi-Tang has inhibiting effects on the development of transplanted uterine tissue. And these effects may be related with decreased production of MCP-1, TNF-, and decreased expression of COX-2 and VEGF infiltration by administration of Bojungikgi-Tang.

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