[Clinical analysis of 25 cases of malignant transformation of endometriosis of the ovary].

OBJECTIVE: To study clinicopathologic characteristics, treatment and prognostic factors of malignant transformation of endometriosis of the ovary. METHODS: From 1981 to 1999, a total of 25 patients with malignant transformation of endometriosis of the ovary were retrospectively analyzed. RESULTS: The main symptoms were pelvic masses, abdominal pain, abdominal distension and abnormal vaginal bleeding or discharge. Histological type: of the 25 cases, 14 were endometrioid carcinomas, 2 were clear-cell carcinomas, 2 were adenoacanthoma, 1 was serous papillary adenocarcinomas, 6 were mixed epithelium tumor of ovary. The exact area of histologic transition from benign to malignant epithelium was observed in 25 patients. Stage: stage I 14, stage II 7, stage III 3, stage IV 1. The actual 5-year survival rate was 77.7%. CONCLUSIONS: The exact incidence and prevalence of malignant transformation in endomertriosis is unknown. Radical tumor resection combined with chemotherapy is the main therapeutic approach for malignant transformation of endometriosis of the ovary.