Research progress on the role of Beclin1 in endometriosis

Endometriosis (EMS) is a common gynecological disease in women of reproductive age that causes dysmenorrhea, chronic pelvic pain and infertility, resulting in a major reduction in health-related quality of life. The incidence rate of EMS has increased in recent years. However, the underlying etiology of EMS remains to be fully elucidated. At present, autophagy has become a hotspot of research, and extensive studies have been focused on the involvement of autophagy in EMS. Emerging evidence suggests that there is a close relationship between Beclin1 gene, an essential mediator of autophagy, and EMS. This article reviews the role of Beclin1 in the development and progression of EMS, exploring the potential value of Beclin1 as a therapeutic target for EMS. Key words: Endometriosis; Autophagy; Apoptosis; Beclin1 gene