Development of endometriosis-like lesions in KO/KO mice and control WT/WT mice.

Endometriosis-like lesions in KO/KO mice and control WT/WT mice were numbered and their sizes measured under fluorescence stereomicroscopy at sacrifice (A, B). Parallel experiments were performed where rhMIF (0.008 mg/kg) was added back to KO/KO mice (C, D), while ISO-1 (4 mg/kg) was used to treat WT/WT mice (E, F). Data are from 5 or 6 mice per group and expressed as mean ± SEM;*, p< 0.05, **, p< 0.01 and ***, p< 0.001 compared with the corresponding control group with the unpaired t-test.