Variable Chlorhexidine Tolerance Across Klebsiella Species from a Single Facility

This preprint evaluated in vitro chlorhexidine tolerance across different Klebsiella species isolated from a single hospital facility where chlorhexidine use was widespread, using MIC testing alongside whole-genome sequencing. The authors found that chlorhexidine tolerance varied by species, with Klebsiella quasipneumoniae showing the highest MICs, and they reported no clear evidence of acquired resistance; instead, chromosomal efflux pumps were observed in some typically environmental species. The main caveat stated by the study design is that conclusions are based on isolates from one facility and on in vitro measurements rather than clinical outcomes. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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