The Frequency of Epidermal Growth Factor Receptor (EGFR) Mutation in Patients with Lung Cancer Referred to the Lung Diseases Hospital; A Cross Sectional Study

Abstract Background Various studies showed the usage of epidermal growth factor receptors (EGFRs) gene mutations in the therapeutic plan of patients with advanced lung cancer. This study aimed to investigate the frequency and types of EGFR gene mutations among Iranian patients with lung cancer referred to a specialized lung diseases hospital from 2014 to 2019. Results The study was included 570 individuals, with an average age of 58.74 years old, of which 51.6% were men and 48.4% were women. Gene mutations were present in 113 of the 570 (19.8%) participants. There was deletion, replacement, and deletion and replacement in 65 (57%), 48 (42.1%), and (0.9%) cases, respectively. The mutation was significantly higher among women (P = 0.001); in detail, deletion was higher among female participants, although the replacement mutation was the same in male and female groups. There were no significant differences in mutation among different age groups (P = 0.05). Conclusion EGFR gene mutations, associated with lung cancer and could help patients' therapeutic plan, had the frequency of about 19.8% among Iranian patients with lung cancer.