Assessing the safety and efficacy of a novel intra-nasal high flow cannula for brain cooling

Abstract Targeted temperature management plays an important role in the treatment of myriad critical illnesses. Invasive therapies such as ECMO and cooled intravenous fluid are available but are invasive and not without risk. Noninvasive therapies are also available such as ice packs and cooling blankets but like the invasive options these do not provide isolated brain cooling. This off-target cooling likely has hemodynamic, coagulopathic and other effects which may not be desired. Non-invasive, quick-onset and portable options for control of brain temperature remain lacking. Here, we are testing a non-invasive intra-nasal cooling system which provides cooled air to facilitate brain cooling. The goal of this study is to assess the efficacy and short- and medium-term safety of a novel, intranasal high flow cooled air device on a large animal model system.