Aptamer-based DNA nanoswitches for multiplexed protein detection

2026 · doi:10.64898/2026.05.01.722269
preprint OA: closed CC-BY-NC-4.0
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Abstract

Simple, modular platforms for detecting biologically relevant proteins are critical for applications in clinical diagnostics, healthcare, and research. Here, we have combined aptamer-based protein recognition with our conformationally-responsive DNA nanoswitches to enable simple, sensitive and specific protein detection. We demonstrate dual detection of two clinically relevant blood proteins, thrombin and VEGF as initial proof of concept.
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Abstract Simple, modular platforms for detecting biologically relevant proteins are critical for applications in clinical diagnostics, healthcare, and research. Here, we have combined aptamer-based protein recognition with our conformationally-responsive DNA nanoswitches to enable simple, sensitive and specific protein detection. We demonstrate dual detection of two clinically relevant blood proteins, thrombin and VEGF as initial proof of concept. Competing Interest Statement K.H. and A.R.C. have intellectual property related to DNA nanoswitches. All other authors declare that they have no competing interests. Funder Information Declared National Institute of General Medical Sciences, https://ror.org/04q48ey07, R35GM124720, R35GM150672 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

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License: CC-BY-NC-4.0