Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis - Fig 4

Annelyn Torres-Reverón (5650028), Maahrose Rana (8298858), Varesh Gorabi (8298861), Leslie L. Rivera-Lopez (5963024), Caroline B. Appleyard (5650037)
2020 · doi:10.1371/journal.pone.0227456.g004 · W6941975480
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This study investigated the effects of short-term antalarmin treatment on adrenal gland receptor expression in a rat model of endometriosis. Researchers quantified mRNA levels for mineralocorticoid receptors, glucocorticoid receptors, and corticotrophin-releasing hormone receptors type 1 and 2 to assess changes in receptor ratios following intervention. The results indicated that antalarmin significantly altered the balance between these specific receptors within the adrenal tissue compared to control groups. This paper is centrally about endometriosis — specifically examining neuroendocrine alterations in a validated rat model of the disease.

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Abstract

mRNA quantification of the mineralocorticoid receptor (MCR2; A), glucocorticoid receptor (GR; B). Ratio of glucocorticoid to mineralocorticoid receptors mRNA expression within the adrenals (C). mRNA quantification of the corticotrophin releasing hormone receptor type 1 (CRHR1; D) and type 2 (CRHR2; E). Ratio of CRHR1 to CRHR2 mRNA expression within the adrenals (F) * represents p< 0.05 on an ANOVA test. Dotted line represents a perfect ratio of 1:1 between receptors expression.
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Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis Fig 4 mRNA quantification of the mineralocorticoid receptor (MCR2; A), glucocorticoid receptor (GR; B). Ratio of glucocorticoid to mineralocorticoid receptors mRNA expression within the adrenals (C). mRNA quantification of the corticotrophin releasing hormone receptor type 1 (CRHR1; D) and type 2 (CRHR2; E). Ratio of CRHR1 to CRHR2 mRNA expression within the adrenals (F) * represents p< 0.05 on an ANOVA test. Dotted line represents a perfect ratio of 1:1 between receptors expression.

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endometriosis

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