Deep brain cancer metastasis detection with wide-volume Raman spectroscopy through a single tapered fiber
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Abstract
We propose a low-invasive method to enable implantable, large volume Raman spectroscopy in arbitrarily deep brain regions of the mouse brain. Using a single tapered fiber as thin as 1 μm at the tip, we identified diagnostic markers of brain metastasis - the most frequent brain tumor in human adults - with overall accuracy ≥ 90%. We view our approach as a promising complement to the existing palette of tools for optical interrogation of the brain.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
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