The ultra-structure of endometrial-myometrial junction in adenomyosis

Objective To study the ultrastructural change in endometrial-myometrial junction associated with adenomyosis.Methods The ultrastructure of endometrial-myometrial junction from 8 patients with adenomyosis and 8 healthy controls was studied using transmission electron microscope.Results Compared with controls,glandular epithelium in adenomyosis presented with dense microvilli on the surface,enlarged and actively functioning mitochondria,but no apoptosis;smooth muscle cells showed irregular alignments,distorted bands,fewer organelles,more mast cells,vacuolated mitochondria,widespread electron-dense particles in the cytoplasm,more surrounding collagen fibers in close adjacency.Conclusion Distorted constitution of endometril-myometrial junction is related to adenomyosis.