Investigation of the Potential Serum Levels of Autophagy 5–protein, Apo-Lipoprotein B-48, and Oxidative Stress Markers in the Early Diagnosis of Patients with Ischemic Stroke

Abstract Background: Stroke is one of the leading causes of death worldwide and has different characteristics. Different physiopathological mechanisms characterize the different subtypes of ischemic stroke. In this study, we investigated the correlation between serum levels of autophagy-5 protein, Apo-lipoprotein B-48, and oxidative stress markers in patients with ischemic stroke. Methods and results: We enrolled 100 participants, including 50 ischemic stroke (IS) patients as the case group and 50 healthy individuals as the control group. Then, we conducted a case-control study at Imam Reza Hospital from March 2019 to April 2020. We quantified the serum levels of ATG5, Apo B-48, and oxidative stress markers in both groups. And we evaluated the incremental diagnostic value of these factors by receiver operating characteristic analysis (ROC) in both groups. The mean serum levels of ATG5, Apo B-48, and oxidative stress markers were higher in the case group than in the control group, with a p–value of less than 0.0001 (p <0.0001).Conclusions: Serum levels of ATG5, Apo B-48, Malonaldehyde (MDA), total oxidative stress (TOS), and total antioxidant capacity (TAC) in patients with IS can be used as novel biomarkers to predict or therapeutically modulate patients with IS.