Effect of atorvastatin on endometriosis patients and its influence on serum MMP-9 expression

Objective: To observe the effect of atorvastatin on endometriosis patients and its influence on matrix metalloproteinase-9(MMP-9) expression in blood.Methods:A total of 78 endometriosis cases were randomly divided into two groups by half.Patients in treatment group were treated with atorvastatin,and patients in control group were treated with mifepristone both for 8 consecutive weeks.E2,MMP-9 levels were determined and compared before and after treatment and also compared between groups.Results: After treatment,score of dysmenorrhea scale was significantly lower in observation group(P0.01),but no significant difference between two groups was observed after treatment(P0.05);there was significant difference in amenorrhea incidence 4 and 8 weeks after treatment(P0.01);E2 and MMP-9 levels were significantly lower after treatment(P0.01)showing significant difference between two groups(P0.01).Conclusions:Atorvastatin can inhibit MMP-9 expression with little side effects,thus it can be used for endometriosis.