Cardiorespiratory fitness in the population with different glucose metabolic statuses: low cardiorespiratory fitness increases the risk of early abnormal glucose metabolism

Background: Low cardiorespiratory fitness (CRF) is a risk factor for many chronic diseases. This study aims to evaluate CRF in the population with different glucose metabolism and explore its relationship with early abnormal glucose metabolism. Method: A total of 93 participants were assigned to three groups: normal glucose tolerance (NGT); impaired glucose regulation (IGR); and newly diagnosed type 2 diabetes mellitus (T2DM) through OGTT. CPET was performed to evaluate CRF. Results: and Conclusion: The anaerobic threshold (AT), oxygen uptake (VO 2 ) and maximum VO 2 /kg in male participants, and the AT heart rate (HR), AT systolic blood pressure (Psys) and the maximum VO 2 /kg in female participants, were lower in the T2DM and IGR groups than in the NGT group. Regression analysis shows that the maximum VO 2 /kg and 1-min HR recovery of female 2-h blood glucose entered into the equation, the maximum VO 2 of male participants was related to pre-diabetes and AT power was related to new-onset diabetes, the AT Psys of female participants was related to pre-diabetes and AT HR was related to new-onset diabetes. CRF was closely associated with 2-h blood glucose after glucose load and was an important risk factor for pre-diabetes and new-onset diabetes.