Ovarian Cancer Risk Associated With Benign Gynecologic Conditions in African American Women [13J]

INTRODUCTION: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans (AA). Therefore, we examined the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in AA women. METHODS: Data from a large population-based, multi-center case-control study of epithelial ovarian cancer in AA women were analyzed to estimate the association between self-reported history of endometriosis, fibroid, pelvic inflammatory disease (PID), and ovarian cyst with epithelial ovarian cancer. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between individual and composite gynecologic conditions and ovarian cancer. RESULTS: 628 cases and 752 controls enrolled in the African American Cancer Epidemiology Study between December 1, 2010 and December 31, 2015 were included in the analysis. After adjusting for potential confounders, a history of endometriosis was associated with ovarian cancer (OR 1.73; 95% CI 1.06-2.81). A modest association was observed with PID (OR 1.57; 95% CI 0.98-2.51), while no association was observed in women with a history of fibroid or ovarian cyst. A positive trend was observed for an increasing number of reported gynecologic conditions (p=0.002) with consistency across histologic subtypes and among both oral contraceptive users and non-users. CONCLUSION: A self-reported history of endometriosis among AA women was associated with increased risk of ovarian cancer. Having multiple benign gynecologic conditions had a cumulative effect on ovarian cancer risk.